Comparison of Coronary Artery Calcification and Some Coronary Artery Calcification Risk Factors in Patients on Haemodialysis and in Patients with Type 2 Diabetes

Krajnc, Mitja; Pečovnik-Balon, Breda; Hojs, Radovan; Rupreht, Mitja

doi:10.1177/147323001103900336

Cited by 5 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the categories of CACS which was defined in previous studies,[7] we selected CACS ≥80 which is considered as average risk of coronary artery events and higher.…”

Section: Methodsmentioning

confidence: 99%

Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women

et al. 2017

View full text Add to dashboard Cite

BackgroundSince 1991 many studies evaluated the link between cardiovascular diseases and osteoporosis, two age-related conditions, but the main common pathologic pathway has not been determined yet. The histological similarity between arterial calcified plaque and bone matrix and involvement of similar cells and mediators provide a special field of research. Therefore in the present study, we aimed to evaluate the relationship between coronary artery calcium score (CACS) as a surrogate marker of atherosclerosis and bone mediators and parameters in postmenopausal women.MethodsEleven postmenopausal women who had CACS higher than 80 were enrolled into the study and underwent bone densitometry. In addition, their serum and urine samples were taken for measuring osteoprotegerin, osteocalcin, and β cross laps. Patients' 10-year probability of fracture was calculated by the World Health Organization fracture-risk assessment tool (FRAX).ResultsThe regression analysis of our results showed the association between CACS and OC (std β=0.66, 95% confidence interval [CI] 5.47-72.27, P=0.027), femoral bone density (std β=−0.6, 95% CI -6864.34-14.27, P=0.05) and T-score (std β=−0.6, 95% CI −773.08-1.28, P=0.05) which remained significant after adjustment for age, weight, years since menopause and body mass index. No association was found between CACS and osteoprotegerin, spinal bone density and FRAX score.ConclusionsIn conclusion, this pilot study with small sample size showed the potential association between CACS and osteocalcin, femoral bone density and T-score. However, the relationship between CACS and osteoprotegerin, receptor activator of nuclear factor-kappa B ligand, FRAX score and other bone parameters remain to be clarified in larger sample size studies.

show abstract

“…Based on the categories of CACS which was defined in previous studies,[7] we selected CACS ≥80 which is considered as average risk of coronary artery events and higher.…”

Section: Methodsmentioning

confidence: 99%

Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In a 10-year prospective study on 137 CKD patients, the authors found that severe CAC was an important predictor of cardiovascular mortality[ 151 ]. Krajnc et al [ 152 ] compared CAC score between patients on hemodialysis and diabetic patients without renal involvement and found higher CAC score in the hemodialysis group, with the difference between both groups especially evident in the very high risk CAC score category. Besides being an adverse prognostic sign, higher CAC has been associated with faster progression of CKD to ESRD[ 153 ].…”

Section: Imaging Techniquesmentioning

confidence: 99%

Diabetic patients with chronic kidney disease: Non-invasive assessment of cardiovascular risk

Piko¹,

Bevc²,

Ekart³

et al. 2021

WJD

View full text Add to dashboard Cite

The prevalence and burden of diabetes mellitus and chronic kidney disease on global health and socioeconomic development is already heavy and still rising. Diabetes mellitus by itself is linked to adverse cardiovascular events, and the presence of concomitant chronic kidney disease further amplifies cardiovascular risk. The culmination of traditional (male gender, smoking, advanced age, obesity, arterial hypertension and dyslipidemia) and non-traditional risk factors (anemia, inflammation, proteinuria, volume overload, mineral metabolism abnormalities, oxidative stress, etc. ) contributes to advanced atherosclerosis and increased cardiovascular risk. To decrease the morbidity and mortality of these patients due to cardiovascular causes, timely and efficient cardiovascular risk assessment is of huge importance. Cardiovascular risk assessment can be based on laboratory parameters, imaging techniques, arterial stiffness parameters, ankle-brachial index and 24 h blood pressure measurements. Newer methods include epigenetic markers, soluble adhesion molecules, cytokines and markers of oxidative stress. In this review, the authors present several non-invasive methods of cardiovascular risk assessment in patients with diabetes mellitus and chronic kidney disease.

show abstract

The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies

Roshanzamir

Miraghajani

Rouhani

et al. 2017

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

Comparison of Coronary Artery Calcification and Some Coronary Artery Calcification Risk Factors in Patients on Haemodialysis and in Patients with Type 2 Diabetes

Cited by 5 publications

References 52 publications

Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women

Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women

Diabetic patients with chronic kidney disease: Non-invasive assessment of cardiovascular risk

The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies

Contact Info

Product

Resources

About