Comparison of data-driven identified hypertension-protective dietary patterns among Chinese adults: based on a nationwide study

Yang, Yuxiang; Piao, Wei; Cai, Shuya; Huang, Kun; Yuan, Changzheng; Cheng, Xian; Zhang, Ling; Li, Yuge; Zhao, Liyun; Yu, Dongmei

doi:10.1007/s00394-023-03195-9

Cited by 3 publications

(3 citation statements)

References 76 publications

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“…To date, although hypertension is a risk factor for cardiovascular disease death, it is also a preventable and controllable factor for cardiovascular disease events ( Prenissl et al, 2019 ). Although the pathogenesis of hypertension is not yet clear, it has been recognized that hypertension is closely related to lifestyle and dietary habits ( Yang et al, 2023 ). Accumulating evidence supports that consumption of too much salt constitutes one of the risk factors of hypertension ( Vargas-Meza et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus

Jia,

Yang,

Jia

et al. 2024

Front. Neurosci.

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BackgroundLong term hypertension seriously promotes target organ damage in the brain and heart, and has increasingly become serious public health problem worldwide. The anti-hypertensive effects of capsaicin has been reported, however, the role and mechanism of capsaicin within the brain on salt-induced hypertension have yet to be elucidated. This study aimed to verify the hypothesis that capsaicin attenuates salt-induced hypertension via the AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus (PVN).MethodsDahl salt-sensitive (Dahl S) rats were used as animal model for the present study. Rats were randomly divided into four groups based on their dietary regimen (0.3% normal salt diet and 8% high salt diet) and treatment methods (infusion of vehicle or capsaicin in the PVN). Capsaicin was chronically administered in the PVN throughout the animal experiment phase of the study that lasted 6 weeks.ResultsOur results demonstrated that PVN pretreatment with capsaicin can slow down raise of the blood pressure elevation and heart rate (HR) of Dahl S hypertensive rats given high salt diet. Interestingly, the cardiac hypertrophy was significantly improved. Furthermore, PVN pretreatment with capsaicin induced decrease in the expression of mRNA expression of NADPH oxidase-2 (NOX2), inducible nitric oxide synthase (iNOS), NOX4, p-IKKβ and proinflammatory cytokines and increase in number of positive cell level for Nrf2 and HO-1 in the PVN of Dahl S hypertensive rats. Additionally, the protein expressions of phosphatidylinositol 3-kinase (p-PI3K) and phosphorylated protein kinase-B (p-AKT) were decreased, phosphorylated adenosine monophosphate-activated protein kinase (p-AMPK) were increased after the PVN pretreatment with capsaicin.ConclusionCapsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/iNOS pathway in the PVN.

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Section: Discussionmentioning

confidence: 99%

Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus

Jia,

Yang,

Jia

et al. 2024

Front. Neurosci.

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“…Dietary patterns were derived using RRR, seven response variables, namely dietary fiber, thiamine, riboflavin, vitamin C, calcium, magnesium, and potassium were selected due to their demonstrated inverse association with hypertension [ 13 , 26 ]. Based on the nutritional composition and intake of various foods, a total of 25 food groups were identified as predictive variables: rice and its products, wheat flour products, grains, potatoes, beans and their products, fried foods, fresh vegetables, dried vegetables, pickled vegetables, milk and dairy products, pork, poultry meat (including chicken), beef (including cattle), sheep and other livestock meat (excluding poultry), animal offal (such as liver), seafood (including fish and shellfish), eggs and egg products, peanuts and other nut seeds, fungi and algae, fruits, carbonated drinks, coffee, other sugary drinks, fresh vegetable juice, alcohol and snacks.…”

Section: Methodsmentioning

confidence: 99%

“…This approach, initially proposed by Hoffman and widely adopted in nutritional epidemiology, combines both prior and posterior methods [ 11 ]. It determines dietary patterns by identifying the appropriate mediator between diet and disease, thereby addressing the limitations of priori methods that may lack significant correlation with the target disease and posteriori methods that cannot be generalized to the population [ 12 , 13 ]. In this study, the RRR method was employed to analyze dietary patterns, which not only maximized the explanation of hypertension-related response variables but also reflects the actual dietary status of Jiangsu residents.…”

Section: Introductionmentioning

confidence: 99%

Sex differences and dietary patterns in the association of air pollutants and hypertension

Zhang,

Wang,

Xie

et al. 2024

BMC Public Health

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Background Hypertension is one of the major public health problems in China. Limited evidence exists regarding sex differences in the association between hypertension and air pollutants, as well as the impact of dietary factors on the relationship between air pollutants and hypertension. The aim of this study was to investigate the sex-specific effects of dietary patterns on the association between fine particulate matter (PM2.5), ozone(O3) and hypertension in adults residing in Jiangsu Province of China. Methods A total of 3189 adults from the 2015 China Adult Chronic Disease and Nutrition Surveillance in Jiangsu Province were included in this study. PM2.5 and O3 concentrations were estimated using satellite space-time models and assigned to each participant. Dietary patterns were determined by reduced rank regression (RRR), and multivariate logistic regression was used to assess the associations of the obtained dietary patterns with air pollutants and hypertension risk. Results After adjusting for confounding variables, we found that males were more sensitive to long-term exposure to PM2.5 (Odds ratio (OR) = 1.42 95%CI:1.08,1.87), and females were more sensitive to long-term exposure to O3 (OR = 1.61 95%CI:1.15,2.23). Traditional southern pattern identified through RRR exhibited a protective effect against hypertension in males (OR = 0.73 95%CI: 0.56,1.00). The results of the interaction between dietary pattern score and PM2.5 revealed that adherence to traditional southern pattern was significantly associated with a decreased risk of hypertension in males (P < 0.05), while no significant association was observed among females. Conclusions Our findings suggested that sex differences existed in the association between dietary patterns, air pollutants and hypertension. Furthermore, we found that adherence to traditional southern pattern may mitigate the risk of long-term PM2.5 exposure-induced hypertension in males.

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Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus

Jia,

Yang,

Jia

et al. 2024

Preprint

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Long term hypertension seriously affects target organ damage such as the brain, heart, and kidneys, and has become an increasingly serious public health problem worldwide. Capsaicin has been proven to improve blood pressure. However, whether capsaicin can reduce salt induced hypertension and the mechanism has yet to be elucidated. This study aimed to identify the AMPK/Akt/iNOS pathway in hypothalamic paraventricular nucleus (PVN) mediates capsaicin in improving the process of high salt induced hypertension. Dahl salt-sensitive (Dahl S) rats were uesed as the animal model for the present study. All rats were randomly divided into four groups based on their dietary regimen (0.3% salt diet and 8% salt diet) and treatment methods. Chronic administration capsaicin to the PVN during the process of blood pressure rise in rats. The entire process lasted for 6 weeks. Our results demonstrated that PVN pretreatment with capsaicin can slow down the blood pressure elevation and heart rate (HR) of Dahl S hypertensive rats. Interestingly, The cardiac hypertrophy was significantly improved. Furthermore, PVN pretreatment with capsaicin induced decrease in mRNA expression of NOX2, Inducible nitric oxide synthase (iNOS), NOX4 and proinfammatory cytokines and increase in positive cell level of Nrf2, p-IKKβ, iNOS and HO-1 in the PVN of Dahl S hypertensive rats. Additionally, the protein expressions of phosphorylated adenosine Monophosphate-activated protein kinase (p-AMPK), the phosphatidylinositol 3-kinase (p-PI3K) and phosphorylated protein kinase-B (p-AKT) were attenuated after PVN pretreatment with capsaicin. Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/iNOS pathway in the PVN.

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Comparison of data-driven identified hypertension-protective dietary patterns among Chinese adults: based on a nationwide study

Cited by 3 publications

References 76 publications

Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus

Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus

Sex differences and dietary patterns in the association of air pollutants and hypertension

Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus

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