Comparison of day surgery between varicose veins with and without superficial venous thrombosis below knee: a propensity score-matched analysis

Xu, Jiatang; Xu, Xiaolin; Huang, Minyi; Xia, Zuqi; Luo, Xianghui; Zheng, Junmeng; Huang, Kai

doi:10.1186/s12872-023-03398-2

Cited by 1 publication

(1 citation statement)

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“…Значна активація процесів тромбоутворення може розглядатися як компенсаторна реакція організму на травму, але зазвичай її некерований характер патогенезу в подальшому призводить до утворення тромбів з розвитком тромбофлебіту в системі вен [21,23].…”

Section: результати обговоренняunclassified

Phleboprotective effect of Saponaria officinalis herbs extract under conditions of experimental venostasis

Tsubanova,

Voloshchuk,

Zastryzhna

2024

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Chronic venous insufficiency has held the leading positions for the last 50 years in the general list of human diseases and has a significant specific weight in the group of cardiovascular pathologies. The number of drugs with phleboprotective effect on the pharmaceutical market of Ukraine and the world is extremely limited. Medicinal plant raw materials with venoconstrictor, antioxidant action and the ability to prevent blood clots can be considered as a promising object as a new phleboprotective medicinal product. The aim of this work was to study the effect of Saponaria officinalis herb extract under conditions of experimental venostasis. Experimental male rats weighing 180-220 g were simulated venostasis by placing a ligature on the tail vein. The dynamics of tail volume increase during 6 hours and the involution of edema after 1, 2, 17 and 24 hours were recorded, as well as blood coagulation time, prothrombin and thrombin time were determined. The researched extract of the common soapwort herb (ECSH) was administered intragastrically at a dose of 20 mg/kg. The comparison drug Eskuvit at a dose of 7.2 mg/kg according to escin. Statistical analysis was performed using descriptive statistics using Microsoft Excel and the Statistica 6.0 package. Convergences were considered favorable at p≤0.05. It was established that the therapeutic and prophylactic administration of ECSH at a dose of 20 mg/kg probably reduces the clinical indicators of transudative edema, which developed as a result of acute venostasis. Administration of ECSH normalizes indicators of general blood coagulation to the level of physiological limits. Therefore, the therapeutic and prophylactic administration of ECSH at a dose of 20 mg/kg during experimental venostasis with transudative edema and increased thrombus formation exerts a powerful phleboprotective effect, which statistically significantly exceeds the effectiveness of the comparison drug Eskuvit. Further studies of anti-inflammatory, membrane-stabilizing, antimicrobial and reparative activity will allow forming the pharmacological profile of ECSH as a potential phleboprotective drug.

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Section: результати обговоренняunclassified