Comparison of de-epithelialized amniotic membrane transplantation and conjunctival autograft after primary pterygium excision

Abstract

Purpose To study the efficacy of deepithelialized amniotic membrane (AM) graft (AmbioDry, Okto Ophtho Inc., Costa Mesa, CA, USA) as an adjunctive therapy after primary pterygium excision in comparison to standard conjunctival autograft. Methods A retrospective review of 23 eyes of 22 patients receiving pterygium excision followed by AM transplantation was performed. The results were compared retrospectively with 40 eyes of 36 patients receiving conjunctival autograft after pterygium excision. All patients were Hispanic. Recurrence was defined as regrowth of fibrovascular tissue over the corneoscleral limbus onto clear cornea in the area of previous pterygium excision. Results The pterygium recurrence rates after AM graft and conjunctival autograft were 35 and 25%, respectively. There was no significant difference in recurrence rate between the two groups (P ¼ 0.56). The mean follow-up period was 5.972.4 months. No major complications were noted in either group. Conclusion This study provides preliminary evidence that de-epithelialized AM graft is as effective as conjunctival autograft in preventing pterygium recurrence in this Southern California Hispanic population.

Comparison of Pterygium Recurrence Rates in Hispanic and White Patients After Primary Excision and Conjunctival Autograft

“…However, amniotic membrane, mitomycin C, and bare sclera recurrence rates reported in studies of primarily Hispanic patients have also been high. 10,11,[13][14][15][16] There remains a need for a prospective randomized trial to accurately delineate the role of Hispanic ethnicity in pterygium recurrence. Despite the limitations of a retrospective trial, our findings are consistent with the growing body of evidence, implicating the role of Hispanic ethnicity in the recurrence of pterygium after CAG.…”

Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review)

“…8D) (78,79). In cases with very large conjunctival defects created following pterygium excision, or if a proper autologous conjunctival graft cannot be harvested, an alternative technique is the use of preserved amniotic membrane, which is readily commercially available and provides an excellent substrate for epithelial regrowth (80). The use of more sophisticated conjunctival surgery is associated with considerably lower recurrence rates, often less than 10% (16,78).…”

Comparison of conjunctival autograft transplantation and amniotic membrane transplantation for pterygium: a meta-analysis

“…Fifteen potentially relevant studies were identified [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Ten studies [16][17][18][19][20][21][22][23][24][25] were excluded from further analysis: two were excluded because they were not relevant [16,17], two were excluded because combined surgical modalities for patients were used [18,19], and six were excluded because there was insufficient information for calculating lnHR or var(lnHR) [20][21][22][23][24][25].…”

“…Ten studies [16][17][18][19][20][21][22][23][24][25] were excluded from further analysis: two were excluded because they were not relevant [16,17], two were excluded because combined surgical modalities for patients were used [18,19], and six were excluded because there was insufficient information for calculating lnHR or var(lnHR) [20][21][22][23][24][25]. A total of five studies remained eligible for pooling risk estimates [11][12][13][14][15].…”