Comparison of dermoscopy and reflectance confocal microscopy accuracy for the diagnosis of psoriasis and lichen planus

Wang, Zi‐Yi; Fei, Wenmin; Li, Cheng‐Xu; Cui, Yong

doi:10.1111/srt.13158

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…As regards dermoscopy, it is a noninvasive tool which allows to increase the accuracy of the diagnosis of psoriasis. 43 Generally, dermoscopic examination of plaque psoriasis shows a distinctive pattern characterized by diffuse white scales and regularly and symmetrically distributed dotted vessels on a light or dull red background. 44 , 45 In our study, we reported that dermoscopic examination may be used not only during the diagnosis but also for assessing the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Brodalumab in Patients with Moderate-to-Severe Plaque Psoriasis Located in Difficult-to-Treat Areas

Cacciapuoti,

Potestio,

Guerrasio

et al. 2023

CCID

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Background Recent knowledge of psoriasis pathogenesis has led to the development of selective drugs. Among these, brodalumab is a monoclonal antibody targeting the interleukin (IL)-17A receptor approved for the treatment of moderate-to-severe plaque psoriasis. Biologics may be considered in patients with milder diseases in case of active psoriatic arthritis, severe impact on patient’s quality of life, and involvement of sensitive and difficult-to-treat areas. These skin locations commonly require systemic drugs. Recently, psoriasis severity monitoring has also changed. Indeed, the clinical evaluation by means of specific efficacy scores was combined with serological evaluation by means of the assay of specific inflammatory biomarkers. Methods An observational study enrolled patients affected by moderate-to-severe plaque psoriasis involving difficult-to-treat areas, undergoing treatment with brodalumab to evaluate the effectiveness and safety of brodalumab in patients with psoriasis affecting difficult-to-treat areas (scalp and palmoplantar regions). Secondary outcomes were the assessment of the development of serum markers of inflammation during the treatment period as well as the evaluation of the dermoscopic features of the affected sites to quantify disease activity and response to treatment. Results Twenty-five patients were included in the study. A statistically significant reduction from baseline in PASI, PSSI, ppPASI and DLQI values as early as week 24 was observed, with further improvement up to week 52. Plasma levels of MMP-3, VEGF-A, and hs-PCR decreased during treatment from week 0 to week 52. Conclusion Our real-life experience suggests brodalumab as a valuable option for the management of psoriasis located in difficult-to-treat areas. Moreover, our study highlights that the use of brodalumab reduces the plasmatic levels of inflammatory biomarkers (MMP-3, VEGF-A and hs-PCR), showing how the drug modulates the skin inflammatory response by reducing systemic inflammation.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Brodalumab in Patients with Moderate-to-Severe Plaque Psoriasis Located in Difficult-to-Treat Areas

Cacciapuoti,

Potestio,

Guerrasio

et al. 2023

CCID

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“…Studies conducted so far have not shown the presence of WS in diseases other than lichen planus [8], and Wang et al [19] found that WS and bluegray dots found in dermoscopy in 65.3% and 61% of 47 patients diagnosed with lichen planus, respectively, are reliable criteria in the differential diagnosis of lichen planus from other dermatoses associated with scaling [18,19]. WS is a marker of the active phase of lichen planus and is used to assess the effectiveness of treatment, as it disappears in course of a properly selected therapy [18].…”

Section: Lichen Planusmentioning

confidence: 91%

“…liszaj płaski [8], a ponadto Wang i wsp. [19] na podstawie przeprowadzonego badania stwierdzili, że siateczka Wickhama i niebiesko-szare kropki występujące w badaniu dermoskopowym odpowiednio u 65,3% i 61% wśród 47 pacjentów ze zdiagnozowanym liszajem płaskim. Zmiany te stanowią wiarygodne kryteria w diagnostyce różnicowej liszaja płaskiego z innymi dermatozami [18,19].…”

Section: Liszaj Płaskiunclassified

“…[19] na podstawie przeprowadzonego badania stwierdzili, że siateczka Wickhama i niebiesko-szare kropki występujące w badaniu dermoskopowym odpowiednio u 65,3% i 61% wśród 47 pacjentów ze zdiagnozowanym liszajem płaskim. Zmiany te stanowią wiarygodne kryteria w diagnostyce różnicowej liszaja płaskiego z innymi dermatozami [18,19]. Siateczka Wickhama stanowi marker aktywnej fazy liszaja płaskiego i jej obecność pozwala na ocenę skuteczności leczenia, gdyż zanika podczas właściwie dobranej terapii [18].…”

Section: Liszaj Płaskiunclassified

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Dermoscopy in the diagnosis of selected inflammatory dermatoses

Fijałkowska¹,

Wojtczak²,

Żebrowska³

2023

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Dermoscopy was initially used as a non-invasive method for differentiation of pigmented lesions and skin cancers. In recent years, its use goes far beyond the area of dermato-oncology and is recognized as an effective technique in the diagnosis of many inflammatory dermatoses. The clinical similarity of these diseases often requires histopathological examination, an invasive and time-consuming technique. Dermoscopy (inflammoscopy) allows for the visualization of structures typical for individual inflammatory skin disorders. Thus it became key diagnostic tool in the daily practice of every dermatologist. We present in this article the use of inflammoscopy in selected inflammatory skin diseases: psoriasis, lichen planus, eczema and pitiriasis rosea.

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“…Currently, the diagnosis of psoriasis is mainly based on the patient's typical clinical manifestations, dermoscopy, and skin biopsy 8,9 . Histopathological examination is an invasive method and has not become routine test for psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Metagenomics reveals unique gut mycobiome biomarkers in psoriasis

Wang,

Sun,

Zhang

et al. 2024

Skin Research and Technology

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PurposeIn present, the diagnosis of psoriasis is mainly based on the patient's typical clinical manifestations, dermoscopy and skin biopsy, and unlike other immune diseases, psoriasis lacks specific indicators in the blood. Therefore, we are required to search novel biomarkers for the diagnosis of psoriasis.MethodsIn this study, we analyzed the composition and the differences of intestinal fungal communities between psoriasis patients and healthy individuals in order to find the intestinal fungal communities associated with the diagnosis of psoriasis. We built a machine learning model and identified potential microbial markers for the diagnosis of psoriasis.ResultsThe results of AUROC (area under ROC) showed that Aspergillus puulaauensis (AUROC = 0.779), Kazachstania africana (AUROC = 0.750) and Torulaspora delbrueckii (AUROC = 0.745) had high predictive ability (AUROC > 0.7) for predicting psoriasis, While Fusarium keratoplasticum (AUROC = 0.670) was relatively lower (AUROC < 0.7).ConclusionThe strategy based on the prediction of intestinal fungal communities provides a new idea for the diagnosis of psoriasis and is expected to become an auxiliary diagnostic method for psoriasis.

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Comparison of dermoscopy and reflectance confocal microscopy accuracy for the diagnosis of psoriasis and lichen planus

Cited by 7 publications

References 29 publications

Effectiveness of Brodalumab in Patients with Moderate-to-Severe Plaque Psoriasis Located in Difficult-to-Treat Areas

Effectiveness of Brodalumab in Patients with Moderate-to-Severe Plaque Psoriasis Located in Difficult-to-Treat Areas

Dermoscopy in the diagnosis of selected inflammatory dermatoses

Metagenomics reveals unique gut mycobiome biomarkers in psoriasis

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