Comparison of Desflurane-induced Circulatory Responses by the Rate of Increase in Inhaled Desflurane Concentration

Kim, Eun Ah; Lee, Seung Seok; Lim, Hyung Sun; Ko, Seonghoon; Lee, Jun Rye; Lee, Sang Kyi; Song, He Sun

doi:10.4097/kjae.2005.49.4.466

Cited by 9 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, patients in the saline injection group showed the same pattern as those in previous studies where blood pressure and heart rate temporarily increased after desflurane inhalation and then gradually decreased [ 3 , 6 , 7 ]. Although it is uncommon that hemodynamic responses produced by desflurane are actually harmful to patients, there are studies documenting the occurrence of severe tachycardia (HR > 160 beats/min) or hypertension (systolic BP > 200 mmHg) during induction of anesthesia [ 3 , 6 , 7 ]. We also found a case of severe systolic hypertension (> 180 mmHg).…”

Section: Discussionsupporting

confidence: 80%

“…Although it is uncommon that hemodynamic responses produced by desflurane are actually harmful to patients, there are studies documenting the occurrence of severe tachycardia (HR > 160 beats/min) or hypertension (systolic BP > 200 mmHg) during induction of anesthesia [3,6,7]. We also found a case of severe systolic hypertension (> 180 mmHg).…”

Section: Discussionmentioning

confidence: 49%

“…Diverse methods including medications (fentanyl, esmolol and lidocaine), and controlling of the rate of increase in inhaled desflurane concentration have been used to reduce these hemodynamic responses [1,3,4]. Opioids such as fentanyl effectively controlled hypertension and tachycardia caused by inhalation of desflurane [1].…”

Section: Discussionmentioning

confidence: 99%

“…This could be a serious complication leading to myocardial ischemia in a patient suffering from cardiovascular disease [ 2 ]. Therefore, a variety of methods have been investigated to control a sympathetic stimulation by desflurane [ 1 , 3 , 4 ]. Opioids can be only used clinically and esmolol, a β-adrenergic receptor blocker, attenuated the heart rate response but no other response [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of intravenous labetalol administration on hemodynamic responses during desflurane inhalation

Seok

Kim

Heo

et al. 2012

Korean J Anesthesiol

View full text Add to dashboard Cite

BackgroundInspired concentrations of desflurane ≥ 1 minimum alveolar anesthetic concentration (MAC) have been related to sympathetic stimulation such as hypertension and tachycardia. The current study examined whether labetalol, an α1 and β-adrenergic antagonist would blunt these hemodynamic responses.MethodsFifty-four ASA physical status I patients, aged 20-60 years, were enrolled in this study. The patients were randomly divided into 2 groups. The breathing circuit was primed with an end-tidal desflurane concentration of 1.2 MAC in 6 L/min O2. Normal saline 5 ml or labetalol 0.3 mg/kg was injected into groups S and L respectively. After 5 minutes, anesthesia was induced with intravenous etomidate 0.2 mg/kg and vecuronium 0.1 mg/kg. Each patient inhaled desflurane through a tight fitting facemask. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and end-tidal concentration of desflurane (et-des) were measured at 5 minutes after saline or labetalol injection (baseline) and every 1 minute for 5 minutes after desflurane inhalation and for 2 minutes after intubation.ResultsIn the saline injection group (group S), desflurane inhalation increased heart rate and blood pressure, while labetalol 0.3 mg/kg attenuated the heart rate and blood pressure increase in group L. After tracheal intubation, heart rate and blood pressure were significantly lower in group L than in group S.ConclusionsThese results demonstrate that administration of intravenous labetalol is effective in attenuating tracheal intubation and desflurane-induced hemodynamic responses.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of intravenous labetalol administration on hemodynamic responses during desflurane inhalation

Seok

Kim

Heo

et al. 2012

Korean J Anesthesiol

View full text Add to dashboard Cite

show abstract

“…This was because we had used propofol for induction, and it has been shown in a previous study that propofol reduces desflurane-mediated sympathetic activation in humans (11). Another reason was that the rise in the end-tidal concentrations of desflurane occurred in a controlled manner in our study, and a slow increase in inhaled desflurane concentration has been reported to attenuate the circulatory responses (12).…”

Section: Discussionmentioning

confidence: 83%

Untitled

2014

Turk J Anesth Reanim

View full text Add to dashboard Cite

Desflurane-induced Hemodynamic Changes in Patients with Hypertension

Kim

Lee

Lim

et al. 2007

Korean J Anesthesiol

View full text Add to dashboard Cite

Background: A rapid increase in the desflurane concentration induces tachycardia and hypertension and increases the plasma catecholamine concentration. This study compared the desflurane-induced hemodynamic responses in hypertensive patients with those of normotensive patients.Methods: Sixty patients, 30 normotensive patient (group 1) and 30 hypertensive patients (group 2), were scheduled to undergo elective surgery under general anesthesia. The hypertensive patients have been taking regular antihypertensive drugs and their blood pressure and heart rate was well controlled. Thirty normotensive patients were not premedicated. The inspired concentration of desflurane through the mask was increased abruptly to 12.0 vol%. The target was to produce an end-tidal concentration of desflurane (E T desf) of 10.0 vol% which was maintained until the end of the study by adjusting the vaporizer dial setting. The heart rate (HR), blood pressure (BP), cardiac index (CI), systemic vascular resistance (SVR), E T desf, end-tidal concentration of carbon dioxide, and peripheral oxygen saturation were measured at the baseline and every 30 seconds for 5 minutes after inhaling of desflurane and for 2 minutes after intubation.Results: The HR, BP, and CI increased significantly in the two groups compared with the baseline. However, the HR, blood pressure, CI, SVR, and E T desf were similar in both groups. In addition, there were no significant differences of hemodynamic changes between the β-blocker and the calcium channel blocker in the hypertensive patients.Conclusions: In patients with well-controlled hypertension, the hemodynamic responses to desflurane are similar to those in normotensive patients.

show abstract

Comparison of Desflurane-induced Circulatory Responses by the Rate of Increase in Inhaled Desflurane Concentration

Cited by 9 publications

References 17 publications

The effect of intravenous labetalol administration on hemodynamic responses during desflurane inhalation

The effect of intravenous labetalol administration on hemodynamic responses during desflurane inhalation

Untitled

Desflurane-induced Hemodynamic Changes in Patients with Hypertension

Contact Info

Product

Resources

About