Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery

Mahjoubifard, Maziar; Heidari, Mehdi; Dahmardeh, Maryam; Mirtajani, Seyed Bashir; Jahangirifard, Alireza

doi:10.1155/2020/4814037

Cited by 11 publications

(17 citation statements)

References 22 publications

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“…Only one study compared fentanyl, dexmedetomidine, and lidocaine [11]. All other studies have compared only fentanyl and dexmedetomidine [12][13][14][15][16][17][18]. In this meta-analysis, lidocaine was ignored, as the aim of this meta-analysis was to compare fentanyl and dexmedetomidine.…”

Section: Resultsmentioning

confidence: 99%

“…neurosurgical procedure [12], and cardiac surgery [18]. All other studies included all kinds of elective surgical procedures [13][14][15][16][17].…”

Section: Resultsmentioning

confidence: 99%

“…All eight studies reported HR at baseline [11][12][13][14][15][16][17][18]. The meta-analysis results showed no significant difference in HR between the two groups at baseline (MD = 1.48; 95% CI: -0.84, 3.81; P = 0.21, I 2 = 53%), as shown in Figure 3.…”

Section: Hr At Baselinementioning

confidence: 99%

“…The meta-analysis results showed no significant difference in HR between the two groups at baseline (MD = 1.48; 95% CI: -0.84, 3.81; P = 0.21, I 2 = 53%), as shown in Figure 3. Source: [11][12][13][14][15][16][17][18].…”

Section: Hr At Baselinementioning

confidence: 99%

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Comparison of Fentanyl and Dexmedetomidine in Preventing an Increase in Heart Rate During Intubation Among Patients Undergoing General Anesthesia: A Meta-Analysis

Mohsin¹,

Ganaie²,

Kundi³

et al. 2022

Cureus

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General anesthesia induction, tracheal intubation, extubation, and laryngoscopy are associated with specific hemodynamic changes. Tracheal intubation and laryngoscopy are related to sympathetic stimulation and lead to hypertension and tachycardia. Recent studies have shown that dexmedetomidine is safe and effective as it does not depress respiratory function. This meta-analysis aims to compare the efficacy of dexmedetomidine and fentanyl in preventing an increase in heart rate (HR) during intubation among patients undergoing general anesthesia. A systematic literature search was done using PubMed, Cochrane Library, and Embase to assess studies comparing the efficacy of dexmedetomidine and fentanyl in preventing an increase in HR during intubation. A meta-analysis was done utilizing a random-effects model, and mean differences of HR were determined between fentanyl and dexmedetomidine at baseline, one minute, five minutes, and 10 minutes of intubation. In this meta-analysis, eight randomized control trials were included, involving 548 patients (274 in the fentanyl group and 274 in the dexmedetomidine group). The findings showed that significant difference of HR was significantly lower in the dexmedetomidine group than the fentanyl group at one minute of intubation (mean difference = -8.46; P-value = 0.003), at five minutes of intubation (mean difference = -7.51; P-value = 0.001), and at 10 minutes of intubation (mean difference = -5.15; P-value = 0.030). In the current meta-analysis, dexmedetomidine was better than fentanyl in preventing tachycardia following endotracheal intubation. HR was significantly lower at one minute, five minutes, and 10 minutes after intubation in the dexmedetomidine group compared to the fentanyl group.

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Section: Resultsmentioning

confidence: 99%

“…neurosurgical procedure [12], and cardiac surgery [18]. All other studies included all kinds of elective surgical procedures [13][14][15][16][17].…”

Section: Resultsmentioning

confidence: 99%

Section: Hr At Baselinementioning

confidence: 99%

Section: Hr At Baselinementioning

confidence: 99%

See 2 more Smart Citations

Comparison of Fentanyl and Dexmedetomidine in Preventing an Increase in Heart Rate During Intubation Among Patients Undergoing General Anesthesia: A Meta-Analysis

Mohsin¹,

Ganaie²,

Kundi³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…21 Open discectomy is the most common treatment for lumbar discectomy. [22][23][24][25] The optimal treatment, however, is prescribed to minimize the invasion of the functional method, speed up the recovery of patients, and decrease complications during the recovery period. The reduction of laserdisc pressure in the form of percutaneous nucleotomy is based on the decrease in volume in a closed hydraulic space, resulting in a sharp drop in pressure.…”

Section: Introductionmentioning

confidence: 99%

Laser Therapy in Lumbar Disc Surgery – A Narrative Review

Hosseini

Allameh

2020

J Lasers Med Sci

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Introduction: Low back pain is one of the most chronic debilitating conditions involving considerable loss of cash, work, and quality time. Lasers are utilized in different fields of drugs, providing unique advantages. They are useful and advantageous in treating lumbar disc disease. In this research, an attempt is made to examine the role and importance of different lasers in lumbar disc surgeries. Methods: We conducted studies about laser therapy in lumbar disc surgery. Our primary search began with reviewing English-language citations from PubMed and Scopus between 1990 and 2019 using the keywords: (laser therapy) OR (lumbar disc AND disc surgery). The initial search yielded 97 articles. However, about 49 articles were selected and used in the present study. Results: Based on the present study, it can be found that there are several methods of using lasers to treat lumbar disc surgery. These methods all have their strengths and weaknesses. Conclusion:The development of laser lumbar disc surgery can be very helpful due to the reduction of surgical risks and the length of the patients' hospital stay. However, the choice of method used for this type of surgery should be made according to the patient's condition and based on the opinion of the treating physician.

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Comparison of dexmedetomidine, lidocaine and fentanyl in attenuation of haemodynamic response to laryngoscopy and intubation in cardiac surgery patients

Kateel

Verma

Mahajan

2023

JOAPR

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Objective: Laryngoscopy and intubation produce sympathoadrenal response posing risk especially in cardiac patients due to arrhythmias, myocardial ischemia increasing morbidity and mortality. Our aim is to compare lidocaine, fentanyl and dexmedetomidine in attenuation of this response in cardiac surgery patients. Material and Methods: Ninety patients were allocated into 3 groups of 30 participants each. Group A obtained 1µg/kg Dexmedetomidine for 10 minutes before laryngoscopy. Group B 1.5mg/kg of Lidocaine and Group C 2µg/kg Fentanyl 90 seconds before intubation. Hemodynamic parameters like Heart rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) and Rate Pressure Product (RPP) were noted before intubation and 1,3,5,10 and 15 minutes after intubation. Statistical analysis was done using Epi info version 7.2.1.0 statistical software (Chi square test, ANOVA test). Results: Dexmedetomidine had significant reduction in SBP at 1st (p-value=0.003), 5th, 10th and 15th (p-value<0.001) minute and in DBP at 3rd, 5th, 10th and 15th (p-value< 0.001). MAP was significantly reduced with dexmedetomidine at 1st, 3rd, 5th, 10th and 15th minute (p-value</ = 0.001) and RPP at 1st (p-value=0.040), 3rd (p-value=0.001), 5th (p-value=0.001), 10th (p-value<0.001) and 15th(p-value=0.002) minute. Dexmedetomidine had higher fall in HR at 1st, 3rd, 5th, 10th mins which was not statistically significant(p-value>0.05). Conclusion: Dexmedetomidine 1µg/kg given as 10 min infusion before laryngoscopy was more effective than fentanyl and lidocaine in blunting hemodynamic response to laryngoscopy and intubation in cardiac surgery patients. However due to significant hypotension associated with dexmedetomidine, it has to be used with caution in these patients.

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Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery

Cited by 11 publications

References 22 publications

Comparison of Fentanyl and Dexmedetomidine in Preventing an Increase in Heart Rate During Intubation Among Patients Undergoing General Anesthesia: A Meta-Analysis

Comparison of Fentanyl and Dexmedetomidine in Preventing an Increase in Heart Rate During Intubation Among Patients Undergoing General Anesthesia: A Meta-Analysis

Laser Therapy in Lumbar Disc Surgery – A Narrative Review

Comparison of dexmedetomidine, lidocaine and fentanyl in attenuation of haemodynamic response to laryngoscopy and intubation in cardiac surgery patients

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