Comparison of Diagnostic Ability Between Wide-Field Swept-Source Optical Coherence Tomography Imaging Maps and Heidelberg Retina Tomograph 3 Optic Nerve Head Assessment to Discriminate Glaucomatous and Non-glaucomatous Eyes

Kourkoutas, Dimitrios; Triantafyllopoulos, George K.; Georgiou, Iordanis; Karamaounas, Aristotelis; Karamaounas, Nikolaos; Sotiropulos, Konstadinos; Kapralos, Dimitrios

doi:10.7759/cureus.28188

Cited by 3 publications

(3 citation statements)

References 59 publications

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“…All participants underwent thorough ocular examinations including best-corrected distance visual acuity measurements using a Snellen chart (LC1300B; AnnoTek, Shiraz, Iran), intraocular pressure measurement using Goldmann applanation tonometry (AT900; Haag-Streit, Koeniz, Switzerland), anterior segment examination using a slit lamp (SL 3C slit lamp; Topcon Inc., Tokyo, Japan), and fundus examination under a slit lamp using a Volk 90 D lens (Volk Optical Inc., Mentor, OH, USA). The cpRNFLT was measured using swept-source OCT (SS-OCT) (DRI-OCT Triton; Topcon Inc.) [ 15 ] .…”

Section: Methodsmentioning

confidence: 99%

Optical coherence tomography in multiple sclerosis

Najafi,

Ashoori,

Hosseini

et al. 2024

Med Hypothesis Discov Innov Ophthalmol

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Background: Multiple sclerosis (MS) is a chronic neurodegenerative disease that damages myelinated fibers within the central nervous system. Data obtained using optical coherence tomography (OCT) have recently been identified as a potential biomarker for this disease. We aimed to measure circumpapillary retinal nerve fiber layer thickness (cpRNFLT) using OCT and to compare the results in healthy participants with those of individuals having clinically definitive MS with and without a history of optic neuritis. Methods: This cross-sectional study recruited patients with clinically confirmed MS, with and without optic neuritis, and healthy individuals as a control group. We documented demographic characteristics, duration of MS, and time elapsed since the episode of optic neuritis. All participants underwent a thorough ocular examination and measurement of total, superior, and inferior cpRNFLT using swept-source OCT. Results: In participants with MS, women outnumbered men in the subsets with (90%) and without (64%) optic neuritis. The control group comprised approximately similar numbers of men and women. There was a statistically significant difference in total, superior, and inferior cpRNFLT between study groups (all P < 0.001). Pairwise comparisons revealed significantly thinner total, superior, and inferior cpRNFLTs in patients having MS with and without (all P < 0.001) optic neuritis when compared with the controls. We found significantly higher total, superior, and inferior cpRNFLTs in women than in men (all P < 0.05). However, we found no significant correlation between total, superior, or inferior cpRNFLT and patient age, duration of MS, or time elapsed since the optic neuritis episode (all P > 0.05), except for a significant moderate inverse correlation between patient age and total cpRNFLT (r = - 0.41; P < 0.05), indicating a loss of total cpRNFLT with age. Conclusions: Patients with clinically confirmed MS, with or without optic neuritis, had a significantly decreased cpRNFLT compared to that of healthy individuals. There was a significant inverse correlation between age and total cpRNFLT and a difference in cpRNFLT between the sexes, indicating that age and sex may influence the measurement of cpRNFLT using OCT in patients with MS. As a screening tool, OCT should be used along with other existing diagnostic modalities for patients with definite or suspected MS. Further longitudinal studies including various classifications of MS with or without isolated episodes of optic neuritis, along with diagnostic accuracy studies, could provide more robust conclusions on the suitability of OCT as a biomarker of MS.

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Section: Methodsmentioning

confidence: 99%

Optical coherence tomography in multiple sclerosis

Najafi,

Ashoori,

Hosseini

et al. 2024

Med Hypothesis Discov Innov Ophthalmol

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“…The eyes were categorized into two groups: the control group, comprising healthy eyes, and the glaucoma group, consisting of eyes with glaucoma [ 23 ]. This classification was determined based on the results of VF tests and the ONH appearance as established in our prior study [ 24 ]. The control group consisted of subjects who satisfied all the following criteria in both eyes: (1) no previous intraocular surgery, (2) IOP of ≤22 mmHg, (3) clinically normal disc appearance, (4) a normal VF result defined as a mean deviation (MD) and pattern standard deviation (PSD) within 95% confidence intervals (CIs) and a glaucoma hemifield test (GHT) result within normal limits (WNL), and (5) no other significant ophthalmic findings.…”

Section: Methodsmentioning

confidence: 99%

Early Postoperative Changes in Macular Choroidal Thickness After Uncomplicated Phacoemulsification in Patients With and Without Glaucoma: A Swept-Source Optical Coherence Tomography Study

Sotiropulos,

Kourkoutas,

Chatzistefanou

et al. 2023

Cureus

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Purpose The objective of this study was to examine the impact of uncomplicated phacoemulsification on macular choroidal thickness (CT) within the first three postoperative months and to investigate its relationship with postoperative cystoid macular edema (CME) in both glaucomatous and healthy subjects, utilizing swept-source optical coherence tomography (SS-OCT). Methods The non-randomized prospective study involved 82 patients, selected via convenience sampling from the First Department of Ophthalmology, Medical School of Athens, “G. Gennimatas” Hospital, Athens, Greece, between May 2018 and May 2022, undergoing phacoemulsification and intraocular lens (IOL) implantation. The inclusion criteria encompassed patients aged 50 years or above, with or without glaucoma. Patients with ocular pathologies that could influence macula or CT measurements were excluded. Data collection focused on retinal and CT variables of the macular area, measured using SS-OCT. Baseline measurements were established preoperatively, with follow-up assessments at one week, one month, and three months postoperatively to monitor CT and macular edema onset. Results A total of 82 eyes from 82 patients with a mean age of 79.1±8.3 years were included. The study population was divided into a glaucoma group (n=28 eyes) and a control group (n=54 eyes). Our findings indicate a consistently significant increase in macular CT measurements one month after cataract surgery, observed in both glaucomatous and non-glaucomatous eyes. In the first postoperative week, statistically significant changes in CT were observed only in patients with CME. Subsequently, at one-month interval, both patient groups, those with and without CME, exhibited statistically significant changes in CT across all macular sectors. CME was detected in 10 out of 28 eyes in the glaucoma group and in 16 out of 54 eyes in the control group. When evaluating the impact of postoperative CME on groups of glaucomatous and non-glaucomatous eyes, it was observed that glaucomatous eyes exhibited a significantly larger magnitude of change in subfoveal CT (SFCT) (p=0.03) at one month (relative to baseline) compared to non-glaucomatous eyes. There was also a 31% increase in the odds of developing CME for glaucoma patients; this result was not statistically significant (odds ratio {OR}, 1.31; 95% confidence interval {CI}, 0.50-3.47; p=0.57). Conclusions During the early postoperative period, the study revealed a significant increase in CT at one month after phacoemulsification in both glaucomatous and non-glaucomatous eyes. When CME was present, a significantly more pronounced magnitude of change in SFCT was observed at one month in glaucomatous eyes, as opposed to non-glaucomatous eyes. This observation suggests a possible selective susceptibility of glaucomatous eyes in the early postoperative period that requires further research.

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“…Modern imaging technology, such as optical coherence tomography (OCT), has improved the ability to detect and analyze glaucomatous damage [ 7 , 8 ]. POAG manifestations involving the primary optic nerve and the retinal nerve fiber layer and examination of the associated parameters have become a standard of care for monitoring patients with glaucoma [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Anterior Segment Changes in Patients With Glaucoma Following Cataract Surgery

Kouroupaki,

Triantafyllopoulos,

Pateras

et al. 2024

Cureus

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This prospective observational study investigates the impact of cataract surgery on anterior segment parameters in nonglaucomatous and primary open-angle glaucoma (POAG) eyes, utilizing anterior segment optical coherence tomography (AS-OCT). The study involved 42 Caucasian patients, divided into a control group and a POAG group. Comprehensive ophthalmic examinations were performed along with AS-OCT imaging and biometry preoperatively, as well as on one day, one week, and one month following cataract surgery. The results showed significant post-operative changes in anterior chamber depth (ACD) and angle width in both groups, suggesting that cataract surgery may influence the structural parameters associated with glaucoma risk and management. Specifically, a marked increase in ACD and improvement in angle-opening distances were observed, highlighting the potential of cataract extraction to alter intraocular fluid dynamics favorably. Despite these changes, the study noted an initial spike in increased intraocular pressure (IOP) in POAG patients immediately post-operative, which stabilized during follow-up. For the control group, IOP showed gradually reducing IOP values in the follow-up visits. The findings underscore the role of advanced imaging technologies in understanding glaucoma's pathophysiology and the potential benefits of cataract surgery in glaucoma patients. The study advocates for further research with a larger, more diverse patient population and extended follow-up to explore the long-term implications of cataract surgery on glaucoma dynamics, emphasizing the importance of personalized management and treatment strategies particularly for glaucoma patients.

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Comparison of Diagnostic Ability Between Wide-Field Swept-Source Optical Coherence Tomography Imaging Maps and Heidelberg Retina Tomograph 3 Optic Nerve Head Assessment to Discriminate Glaucomatous and Non-glaucomatous Eyes

Cited by 3 publications

References 59 publications

Optical coherence tomography in multiple sclerosis

Optical coherence tomography in multiple sclerosis

Early Postoperative Changes in Macular Choroidal Thickness After Uncomplicated Phacoemulsification in Patients With and Without Glaucoma: A Swept-Source Optical Coherence Tomography Study

Anterior Segment Changes in Patients With Glaucoma Following Cataract Surgery

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