Comparison of Diagnostic Accuracy of Frozen Section with Imprint Cytology for Intraoperative Examination of Sentinel Lymph Node in Early-Stage Endometrial Cancer: Results of Senti-Endo Study

Abstract

FS has better DA than IC for intraoperative examination of SLNs in endometrial cancer. The main limitation of both techniques is in detecting micrometastasis and isolated tumor cells.

Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer

“…Among the 10 patients with metastatic LN disease, the frozen section predicted half of the metastatic nodes found on final pathology, which suggests that the frozen section may not be a reliable method of interpreting the SLN status. This finding is also consistent with other studies reported in the literature in endometrial and cervical cancers [25,26]. Lastly, we found a positive predictive value of 100% (95% CI 60-100) suggesting that there were no false positive frozen sections.…”

A clue towards improving the European Society of Medical Oncology risk group classification in apparent early stage endometrial cancer? Impact of lymphovascular space invasion

“…Although these approaches constitute a more reliable estimation of the risk of recurrence than the physician's judgment, their predictive capability is based on the assumption that all patients within a given risk group are equal. However, in clinical practice, both biological heterogeneity of endometrial tumours and heterogeneity of patients's characteristics within each subgroup have been observed, especially in early-stage EC (Creutzberg et al , 2000; Keys et al , 2004; Ballester et al , 2011, 2012). The current ESMO classification established three risk groups of recurrence based on depth of myometrial invasion, histological grade, and type, without taking into account the LVSI status (Colombo et al , 2013).…”

Lymphatic mapping and sentinel node biopsy in endometrial cancer — a feasibility study using cervical injection of radiotracer and blue dye

“…The discrepancies between frozen section and permanent H&E evaluation are not unknown in the literature [30], and can reach as high as 27% [27]. In the most recent study, Ballester et al reported 56.3% sensitivity for intra-operative diagnostic methods [31]. For introduction of SLN mapping to any gynecological oncology center, this finding should be taken into account [32,33].…”