Comparison of Diagnostic Accuracy of the RTVue Fourier-Domain OCT and the GDx-VCC/ECC Polarimeter to Detect Glaucoma

Garas, Anita; Vargha, P.; Holló, Gábor

doi:10.5301/ejo.5000011

Cited by 19 publications

(25 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar results have been reported by Benítez-del-Castillo et al 14 and Garas et al 15 We also found that the sensitivities of both the devices increased significantly as the severity of glaucomatous VF damage increased. This is similar to the relationship reported between sensitivity to diagnose glaucoma and the severity of glaucomatous VF damage, using various imaging techniques.…”

Section: Discussionsupporting

confidence: 92%

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Rao

Yadav

Addepalli

et al. 2014

Eye

View full text Add to dashboard Cite

Purpose To compare the abilities of retinal nerve fiber layer (RNFL) parameters of spectral domain optical coherence tomograph (SDOCT) and scanning laser polarimeter (GDx enhanced corneal compensation; ECC) in detecting glaucoma. Methods In a cross-sectional study, 215 eyes of 165 subjects (106 eyes of 79 glaucoma patients and 109 eyes of 86 controls) referred by general ophthalmologists for glaucoma evaluation underwent RNFL imaging with SDOCT and GDx ECC. Ability of RNFL parameters of SDOCT to discriminate glaucoma eyes from control eyes was compared with that of GDx ECC using area under operating characteristic curves (AUCs), sensitivities at fixed specificities, and likelihood ratios (LRs). Results AUC of the average RNFL thickness of SDOCT to differentiate glaucoma from control eyes (0.868) was comparable (P ¼ 0.32) to that of GDx ECC (0.855). Sensitivity at 95% specificity was 63.2% for average RNFL thickness of SDOCT and 48.1% for the average RNFL measurement of GDx ECC. LRs of outside normal limits category of SDOCT parameters ranged between 5.6 and 7.7 while the same of GDx ECC parameters ranged between 3.1 and 3.7. LRs of within normal limits category of SDOCT parameters ranged between 0.18 and 0.24 while the same of GDx ECC parameters ranged between 0.20 and 0.32. Conclusion Though AUCs and sensitivities at fixed specificities were comparable between the RNFL parameters of SDOCT and GDx ECC in diagnosing glaucoma, LRs indicated that the RNFL parameters of SDOCT were better in 'ruling in' glaucoma.

show abstract

Section: Discussionsupporting

confidence: 92%

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Rao

Yadav

Addepalli

et al. 2014

Eye

View full text Add to dashboard Cite

show abstract

“…36,[44][45][46] However, these studies have been performed in patients with distinct glaucoma as expressed by presence of visual field defects, while the advantage of polarimetry might exist only in the very early stage of the disease, also referred to as preperimetric glaucoma. For this stage of the disease the literature is sparse and the results yet inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Zotter

Pircher

Götzinger

et al. 2013

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. We presented a novel polarization sensitive optical coherence tomography (PS-OCT) system for measuring retinal nerve fiber layer (RNFL) birefringence, retardation, and thickness, and report on the repeatability of acquiring these quantities. METHODS.A new PS-OCT system, measuring at 840 nm, was developed that supports scan angles of up to 408 3 408 with an A-scan rate of 70 kHz. To test the performance and reproducibility, we measured 10 eyes of 5 healthy human volunteers five times each. All volunteers were imaged further with scanning laser polarimetry (SLP). The obtained RNFL birefringence, retardation, and thickness maps were averaged, and standard deviation maps were calculated. For quantitative comparison between the new PS-OCT and SLP, a circumpapillary evaluation within 2 annular segments (superior and inferior to the optic disc) was performed.RESULTS. High quality RNFL birefringence, retardation, and thickness maps were obtained. Within the superior and inferior segments, the mean retardation for individual eyes ranged from 208 to 28.98 and 17.28 to 28.28, respectively. The quadrant precision over the 5 consecutive measurements for each subject, calculated for the average retardation obtained within the superior and inferior quadrants ranged from 0.168 to 0.698. The mean birefringence ranged from 0.1068/lm to 0.1418/lm superior and 0.1018/lm to 0.1358/lm inferior, with a quadrant precision of 0.0018/lm to 0.0078/lm. The mean RNFL thickness varied from 114 to 150 lm superior, and 111 to 140.9 lm inferior (quadrant precision ranged from 3.6 to 11.9 lm). CONCLUSIONS.The new PS-OCT system showed high image quality and reproducibility, and, therefore, might be a valuable tool for glaucoma diagnosis. (Invest Ophthalmol Vis Sci. 2013; 54:72-84)

show abstract

“…Use of novel structural tests may improve clinical diagnosis, since for early glaucomatous visual field damage to be detected approximately 30 % of the retinal ganglion cells need to be lost [1]. Retinal nerve fiber layer (RNFL) thickness parameters of Fourier-domain (FD) optical coherence tomography (OCT) are believed to have diagnostic accuracy [2][3][4][5][6][7][8]; however, inner macular thickness parameters, which comprise tissue layers directly influenced by glaucomatous ganglion cell loss, show comparable or even higher diagnostic accuracy, particularly in detection of very early glaucoma, and in myopic eyes [9][10][11][12][13][14][15]. The RTVue-100 OCT (Optovue Inc., Fremont, CA, USA) is a new FD OCT systems.…”

Section: Introductionmentioning

confidence: 99%

“…The RTVue-100 OCT (Optovue Inc., Fremont, CA, USA) is a new FD OCT systems. It has been evaluated in detail for clinical usefulness, detection of glaucoma and glaucomatous structural progression [2,3,10,16]. Structure-function relationship has also been established for several parameters of this FD OCT [14,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Comparison of macular ganglion cell complex thickness to total retinal thickness ratio between Hungarian and Japanese eyes

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

Comparison of Diagnostic Accuracy of the RTVue Fourier-Domain OCT and the GDx-VCC/ECC Polarimeter to Detect Glaucoma

Abstract: In this clinical setting, all methods were similarly highly specific, but for localized RNFLT damage RTVue-OCT was statistically and clinically significantly more sensitive than GDx-VCC and GDx-ECC. Most detected glaucoma cases were identified with all 3 methods.

Cited by 19 publications

References 30 publications

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Comparison of macular ganglion cell complex thickness to total retinal thickness ratio between Hungarian and Japanese eyes

Contact Info

Product

Resources

About