Comparison of Diagnostic Performance of the IgA Anti-tTG Test vs IgA Anti–Native Gliadin Antibodies Test in Detection of Celiac Disease in the General Population

Verma, Anil K.; Gatti, Simona; Lionetti, Elena; Galeazzi, Tiziana; Monachesi, Chiara; Franceschini, Elisa; Balanzoni, L.; Scattolo, Novella; Cinquetti, Mauro; Catassi, Carlo

doi:10.1016/j.cgh.2018.03.028

Cited by 10 publications

(6 citation statements)

References 8 publications

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“…The genderwise distribution of CD data revealed that females were considerably higher in number than males affected with CD. Due to the fact that anti tTGA assay is a highly sensitive and yields high positivity, the patients positive for tTGA more likely have enterosopic enteritis (Verma et al, 2018;DeGeorge et al, 2017). CD positive cases were lower than that of HP.…”

Section: Resultsmentioning

confidence: 96%

Evaluation of Putative Association Between Celiac Disease and Helicobacter pylori Infection in Hyderabad, Sindh

Memon

Tunio

Bano

et al. 2020

Pakistan Journal of Scientific & Industrial Research

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Celiac disease is an autoimmune mediated enteropathy caused by ingestion of gluten and affects approximately 1% of the population. It has significant deleterious effects on health and mortality. Helicobacter pylori is the major causative agent of peptic ulcer and gastric cancer. The aim of this study was to assess the prevalence of both H. pylori (HP) and celiac disease (CD) as mono and co-infections and to find out the possible association between CD and presence of HP. A total of 172 blood samples from individuals suspected of CD and HP infection were collected during March to December, 2015 from Hyderabad. Serum analyzed for presence of anti-HP antibodies for evaluation of HP infection and tissue transglutaminase IgA antibodies (tTGA) for detection of CD. The serodiagnosis data revealed that out of 172 samples tested 19.19% were positive for CD which included 6.98% (n=12) male patients, whereas 12.21% (n=21) were females. The HP was detected in 44.77% (n=77) including 22.09% (n=38) males and 22.67% (n=39) females out of the 33 CD positive cases, HP was detected in 17 (9.88%). HP in CD positive cases was found to be 6.60% in males 9.43% in females respectively. The HP prevalence in non-CD patients appeared to be high such as 18.02% and 16.86%. In conclusion, the data of the present study indicates that HP is more prevalent than CD.

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Section: Resultsmentioning

confidence: 96%

Evaluation of Putative Association Between Celiac Disease and Helicobacter pylori Infection in Hyderabad, Sindh

Memon

Tunio

Bano

et al. 2020

Pakistan Journal of Scientific & Industrial Research

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“…Несмотря на то, что окончательная роль антител к ТГ2 в развитии целиакии не до конца ясна, выявлена прямая зависимость между уровнем аутоантител и выраженностью воспалительного процесса в кишечнике [22]. Более того, IgA к ТГ2 являются специфичным и чувствительным маркером целиакии и выявляются практически у всех пациентов [23].…”

Section: иммунологические реакции в основе целиакииunclassified

Celiac disease, wheat allergy, and nonceliac sensitivity to gluten: topical issues of the pathogenesis and diagnosis of gluten-associated diseases

Kaminarskaya¹

2021

Clinical nutrition and metabolism

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Historically, wheat and other gluten-containing grains have been an essential part of the diet of many people worldwide. However, the widespread use of gluten-containing products has led to an increased incidence of adverse reactions associated with their consumption, such as celiac disease and wheat allergy, as well as nonceliac gluten sensitivity, which has become common in recent years. Gluten-associated diseases have similar clinical manifestations (abdominal pain, bloating, diarrhea, nausea, and vomiting). The pathogenetic mechanisms underlying celiac disease and wheat allergy are quite well understood; in both cases, an immune response occurs when wheat proteins are consumed, both with effective treatment. Nonceliac gluten sensitivity is the subject of discussion; however, the processes underlying this disease are not fully understood; thus, its diagnosis and treatment have no unified approach. To date, nonceliac gluten sensitivity is a diagnosis of exclusion, which is established in the absence of markers of celiac disease or wheat allergy and improved following a gluten-free diet. A gluten-free diet is the most effective treatment for gluten-related diseases. However, like any other strict dietary restriction, gluten avoidance can result in reduced intakes of important nutrients, such as dietary fiber, protein, and micronutrients. In recent years, an increasing trend is found in the general population without confirmed gluten-related disorders that gluten-free product consumption or gluten-free diet adherence since gluten avoidance can improve well-being or gluten can be toxic for all human beings According to current guidelines, only patients diagnosed with celiac disease or wheat allergy are advised to follow a strict gluten-free diet. Herein, the modern conception of the immunopathology of gluten-related diseases and an overview of new potential therapies are presented.

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“…It is evident that such an experimental approach had several limitations, as selection and analysis bias may have been introduced in this numerical estimation, in addition to the poorly sensitive and specific screening protocol. Indeed, very recently Verma et al confirmed that almost 40% of anti-tTG IgA positive celiac children are missed when using a screening approach based on AGA IgA only [39].…”

Section: Central Asiamentioning

confidence: 99%

Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence

Poddighe

Rakhimzhanova

Marchenko³

et al. 2019

Medicina

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The current prevalence of pediatric Celiac Disease (CD) is estimated to be around 1% in the general population, worldwide. However, according to the geographic area, a great variability of CD prevalence has been described. Whereas a number of studies are available from Europe, North and South America, Australia, South-West Asia, and North Africa, the knowledge and awareness of CD in large parts of the remaining world areas is definitively poor. In several countries of Central and East Asia, the consumption of wheat is consistent and/or has significantly increased in recent decades, and CD is supposed to be underdiagnosed in children. In this mini-review, we aimed to summarize the current knowledge about the prevalence of pediatric CD in Central and East Asia, paying attention to the HLA-DQ immunogenetic background as well. Indeed, CD is likely not to be as uncommon as previously or currently thought in countries like Russia, Kazakhstan, and China, in addition to India, where pediatric CD has been clearly showed to be quite prevalent. Therefore, there is an urgent need for population-based studies on the prevalence of CD in those countries, especially in children, in order to increase the awareness of this disease and to improve the diagnostic strategy in these areas.

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Comparison of Diagnostic Performance of the IgA Anti-tTG Test vs IgA Anti–Native Gliadin Antibodies Test in Detection of Celiac Disease in the General Population

Cited by 10 publications

References 8 publications

Evaluation of Putative Association Between Celiac Disease and Helicobacter pylori Infection in Hyderabad, Sindh

Evaluation of Putative Association Between Celiac Disease and Helicobacter pylori Infection in Hyderabad, Sindh

Celiac disease, wheat allergy, and nonceliac sensitivity to gluten: topical issues of the pathogenesis and diagnosis of gluten-associated diseases

Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence

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