Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model

Tantowi, Nur Adeelah Che Ahmad; Mohamed, Suhaila; Lau, Seng Fong; Hussin, Paisal

doi:10.1007/s40199-020-00343-y

Cited by 15 publications

(12 citation statements)

References 44 publications

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“…The transcription of these inflammatory genes is regulated by NF- κ B and AP-1, which are important transcription factors [ 26 ]. Specifically, the activation of AP-1 and NF- κ B can promote the release of these inflammatory cytokines, which in turn makes a positive feedback loop to increase the AP-1 and NF- κ B [ 28 ]. Under normal conditions, I κ B α binds to NF- κ B composed of p50 and p65.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Gynura procumbens on RAW264.7 Cells via Regulation of the PI3K/Akt and MAPK Signaling Pathways

Cao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Gynura procumbens is a traditional herb and food extensively cultivated in China and Southeast Asian countries. In this work, the crude extract (CE) of G. procumbens was purified with macroporous resin to obtain the refined fraction, and its anti-inflammatory activity was compared with that of CE. Moreover, the detailed mechanisms of anti-inflammatory activity were also investigated for the first time. The results indicated that CE was more effective in anti-inflammatory activity and it could reduce the secretion of NO, TNF-α, and PGE2 via decreasing the iNOS, TNF-α, and COX-2 genes transcription and related proteins translation, which were associated with the inhibition of AP-1 and NF-κB nuclear translocation and downregulation of PI3K/Akt and MAPK signaling pathways. In conclusion, the extract of G. procumbens has a promising potential in inflammation-related disorders alleviation, and these findings could provide the basis for the comprehensive utilization of G. procumbens and the new functional food development.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Gynura procumbens on RAW264.7 Cells via Regulation of the PI3K/Akt and MAPK Signaling Pathways

Cao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…On the other hand, morusin inhibited the phosphorylation and degradation of IκBb and p65 caused by IL‐1β (Tantowi et al, 2020). Multiple pharmacological characteristics have been found for myricitrin, a flavonoid molecule derived from Myrica Rubra .…”

Section: Nutraceuticalsmentioning

confidence: 99%

“…When exposed to IL-1β, hesperetin showed substantial protective benefits, reduced apoptosis and inflammation, and enhanced chondrocyte maturation in vitro (Shi et al, 2021). It is essential to note that RNA-seq studies revealed that the IL-1-treated chondrocytes had much less TLR-2 and that this decreased TLR-2 was followed by a decrease in NF-κB/Akt signaling, resulting in a protective effect from hesperetin (Tantowi et al, 2020) (Table 3). roots provide dioscin, a natural substance (Gu et al, 2020).…”

Section: Alkaloidsmentioning

confidence: 99%

Potential role of nutraceuticals via targeting a Wnt/β‐catenin and NF‐κB pathway in treatment of osteoarthritis

Alharbi

Afzal

Altamimi

et al. 2022

Journal of Food Biochemistry

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Osteoarthritis (OA) is a disease due to the aging of the articular cartilage, a post‐mitotic tissue that stays functioning until primary homeostatic processes fail. Because of pain and disability, OA significantly influences national healthcare expenses and patient quality of life. It is a whole‐joint illness characterized by inflammatory and oxidative signaling pathways and significant epigenetic alterations that cause cartilage extracellular matrix degradation. The canonical Wnt pathway (Wnt/β‐catenin pathway) and nuclear factor kappa B (NF‐κB) signaling pathways may function in joint tissues by modulating the activity of synovial cells, osteoblasts, and chondrocytes. However, finding innovative ways to treat osteoarthritis and get the joint back to average balance is still a struggle. Nutraceuticals are dietary supplements that promote joint health by balancing anabolic and catabolic signals. New therapeutic methods for OA treatment have been developed based on many research findings that show nutraceuticals have strong anti‐inflammation, antioxidant, anti–bone resorption, and anabolic properties. For the treatment of osteoarthritis, we explore the possible involvement of nutraceuticals that target the Wnt/β‐catenin and NF‐κB pathways. Practical applications In keeping with the aging population, osteoarthritis is becoming more widespread. In this extensive research, we studied the role of the Wnt/β‐catenin and NF‐κB pathway in OA formation and progression. Nutraceuticals that target these OA‐related signaling pathways are a viable therapy option. Wnt/β‐catenin and NF‐κB signaling pathway are inhibited by polyphenols, flavonoids, alkaloids, and vitamins from the nutraceutical category, making them possible therapeutic drugs for OA therapy.

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“…In an in vitro study, apigenin suppressed the expression and proteolytic activity of MMP3 in rabbit articular chondrocytes and rabbit knee joints; additionally, apigenin decreased the expression of MMP1, MMP3, MMP13, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, and -5 in rabbit articular chondrocytes treated with interleukin (IL)-1β [ 31 ]. In an in vivo study, apigenin attenuated cartilage erosion, bone loss, and catabolic factors and reduced the expression of pro-inflammatory cytokines in an MIA-induced rat OA model [ 32 ]. The mechanism of action of apigenin was further identified by Cho et al [ 20 ], who reported that apigenin blocked hypoxia-inducible factor (HIF)-2α-induced osteoarthritic cartilage destruction, downregulated HIF-2α, MMP3, MMP13, ADAMTS4, IL-6, and COX-2 expression, and suppressed HIF-2α-induced MMP3, MMP13 and COX-2 expression by regulating HIF-2α expression ( Figure 2 ).…”

Section: Candidate Therapeutic Agentsmentioning

confidence: 99%

Therapeutic Single Compounds for Osteoarthritis Treatment

et al. 2021

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Osteoarthritis (OA) is an age-related degenerative disease for which an effective disease-modifying therapy is not available. Natural compounds derived from plants have been traditionally used in the clinic to treat OA. Over the years, many studies have explored the treatment of OA using natural extracts. Although various active natural extracts with broad application prospects have been discovered, single compounds are more important for clinical trials than total natural extracts. Moreover, although natural extracts exhibit minimal safety issues, the cytotoxicity and function of all single compounds in a total extract remain unclear. Therefore, understanding single compounds with the ability to inhibit catabolic factor expression is essential for developing therapeutic agents for OA. This review describes effective single compounds recently obtained from natural extracts and the possibility of developing therapeutic agents against OA using these compounds.

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Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model

Cited by 15 publications

References 44 publications

Anti-Inflammatory Effects of Gynura procumbens on RAW264.7 Cells via Regulation of the PI3K/Akt and MAPK Signaling Pathways

Anti-Inflammatory Effects of Gynura procumbens on RAW264.7 Cells via Regulation of the PI3K/Akt and MAPK Signaling Pathways

Potential role of nutraceuticals via targeting a Wnt/β‐catenin and NF‐κB pathway in treatment of osteoarthritis

Therapeutic Single Compounds for Osteoarthritis Treatment

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