Comparison of Different Anticoagulation Regimens Regarding Maternal and Fetal Outcomes in Pregnant Patients With Mechanical Prosthetic Heart Valves (from the Multicenter ANATOLIA-PREG Registry)

A well validated risk stratification index predicts weak material and fetal outcomes in pregnant women with cardiovascular disease

“…Second, MPHVs are highly thrombogenic, and a pregnancy-induced procoagulant status increases the risk of MPHV thrombosis. 3 , 4 In the presented study, there were 20 (25%) patients who had pregnancy with the MPHV. No detailed information has been given about anticoagulation options in these patients' medical treatments.…”

The role of thrombolytic therapy in pregnant patients with prosthetic valve thrombosis

“…However, two major studies showed that low-dose slow/ultra-slow infusion t-PA was associated with an excellent maternal clinical outcome and acceptable (similar to the normal population) fetal outcomes. 4,6 While maternal death was not observed in both studies, fetal losses were 20% and 20.6%, respectively. On the other hand, limited number of studies and case reports reveal that the rate of maternal death is 10%-25% and fetal loss can reach 100% after surgical treatment.…”

“…3 In fact, we have previously stated that PVT was detected in 32% of patients with strict anti-factor Xa follow-up during pregnancy. 4 In other words, it should be known that this patient population is at risk for PVT even if effective anti-factor Xa follow-up is observed. 4,5 Therefore, there is a need to develop more potent anticoagulation regimens that do not harm the fetus as a new strategy.…”

“…4 In other words, it should be known that this patient population is at risk for PVT even if effective anti-factor Xa follow-up is observed. 4,5 Therefore, there is a need to develop more potent anticoagulation regimens that do not harm the fetus as a new strategy.…”

Mechanical Heart Valves, Pregnancy, and Bleeding: A Systematic Review and Meta-Analysis

“…After duplicate removal, 247 studies were identified through database search and screened by title and abstract. A total of 37 studies were finally included 1 2 3 5 8 10 12 13 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 ( Table 1 ). In 22 of the included studies, data were retrospectively collected, 6 10 12 13 17 18 19 20 21 23 24 25 26 28 32 36 37 38 40 41 42 43 44 whereas 15 studies collected data prospectively.…”