Comparison of different automated lesion delineation methods for metabolic tumor volume of 18F-FDG PET/CT in patients with stage I lung adenocarcinoma

Wang, Xiaoyi; Zhao, Yanfeng; Liu, Ying; Yang, Yikun; Zhu, Zheng; Wu, Ning

doi:10.1097/md.0000000000009365

Cited by 21 publications

(23 citation statements)

References 39 publications

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“…To limit multiple comparisons and because the optimal threshold in patients with earlier (stage i) disease is not known, we used a gradient method for mtv delineation. In one study of patients with stage i adenocarcinoma of the lung, a gradient methods of mtv delineation was shown to have the highest accuracy in high-uptake large solid nodules, but a threshold method was best for low-uptake small nonsolid nodules 31 . In patients with head-and-neck tumours, use of threshold or gradient methods to delineate mtv did not significantly influence the prognostic value of that variable 32 .…”

Section: Discussionmentioning

confidence: 99%

Metabolic Tumour Volume Is Prognostic in Patients with Non-Small-Cell Lung Cancer Treated with Stereotactic Ablative Radiotherapy

Dosani¹,

Yang²,

McLay

et al. 2019

Current Oncology

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Introduction Stereotactic ablative radiotherapy (sabr) is a relatively new technique for the curative-intent treatment of patients with inoperable early-stage non-small-cell lung cancer (nsclc). Previous studies have demonstrated a prognostic value for positron emission tomography–computed tomography (pet/ct) parameters, including maximal standardized uptake value (suvmax), metabolic tumour volume (mtv), and total lesion glycolysis (tlg) in lung cancer patients. We aimed to determine which pet/ct parameter is most prognostic of local control (lc) and overall survival (os) in patients treated with sabr for nsclc.Methods We conducted a retrospective review of patients treated with sabr for stage i inoperable nsclc at BC Cancer between 2009 and 2013. The Akaike information criterion was used to compare the prognostic value of the various pet/ct parameters.Results The study included 134 patients with a median age of 76 years. Median tumour diameter was 2.2 cm, gross tumour volume was 8.1 mL, suvmax was 7.9, mtv was 2.4 mL, and tlg was 10.9 suv•mL. The 2-year lc was 92%, and os was 66%. On univariate and multivariate analysis, imaging variables including tumour size, gross tumour volume, suvmax, mtv, and tlg were all associated with worse lc. Tumour size was not associated with significantly worse os, but other imaging variables were. The pet/ct parameter most prognostic of lc was mtv. Compared with suvmax, tlg and mtv were more prognostic of os.Conclusions In patients with early-stage nsclc treated with sabr, mtv appears to be prognostic of lc and os.

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Section: Discussionmentioning

confidence: 99%

Metabolic Tumour Volume Is Prognostic in Patients with Non-Small-Cell Lung Cancer Treated with Stereotactic Ablative Radiotherapy

Dosani¹,

Yang²,

McLay

et al. 2019

Current Oncology

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“…It indicates that BPL algorithm can make the measurement less affected by the segmentation method. With the non-BPL reconstruction method, PET/CT quantitative studies on cervical cancer and lung cancer lesions have con rmed that the iterative adaptive method can improve the MTV measurement accuracy [10,11]. The iterative adaptive method is to get the optimal threshold value by weighting SUV max and SUV mean in the targeted lesion [12].…”

Section: Discussionmentioning

confidence: 99%

“…However, the method using for MTV delineation also needs to be careful and precise. At present, most studies use a xed SUV threshold (such as SUV ≥ 2.5 or SUV ≥ 4.0) or a percentage of SUV max (such as 42% SUV max ) to de ne MTV [8][9][10]. Meanwhile, Xu et al also proposed that using the iterative adaptive method of PET VCAR software (GE Healthcare, Milwaukee) was more accurate than using the SUV max percentage threshold method to determine MTVs [11].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Bayesian Penalized Likelihood Reconstruction Algorithm on Quantitative Accuracy of Positron Emission Tomography Volumetric Measurements

Chen

Huang

et al. 2020

Preprint

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Objectives The metabolic tumor volume (MTV) of positron emission tomography/computed tomography (PET/CT) is an important index to evaluate the prognosis and the responses of treatments. The purpose of this study is to assess the impact of Bayesian Penalized Likelihood (BPL) reconstruction algorithm and segmentation methods on the accuracy of MTV via a phantom study.Methods Using the National Electrical Manufactures Association/International Electrotechnical Commission (NEMA/IEC) image quality phantom, six hot spheres and background were filled with 21.56 KBq/ml and 5.39 KBq/ml Na 18 F (a sphere to background ratio of 4: 1). Acquired images were reconstructed using BPL (β = 400) and non-BPL (Ordered subsets expectation maximization + time of flight + point spread function, OSEM+TOF+PSF) algorithms, respectively. MTVs of six spheres were delineated using maximum standardized uptake value (SUV max ) percentage threshold method and iterative adaptive method, respectively. The actual measured volumes of spheres were used as the standard for comparative analysis.Results The MTVs measurement errors in BPL were 4.96%, -3.00%, 6.18%, 5.20%, -10.00% and 18.33%, which was significantly lower than that in non-BPL ( Z = - 2.562, p = 0.009), and the measurement errors in non-BPL were 16.70%, 10.77%, 26.00%, 30.00%, 61.82% and 113.33%. The optimal percentage SUV max threshold of spheres in BPL algorithm was raged in 40% - 45%, which was not affected by the ball size. And there was no significant difference of MTVs measurement accuracy between the 42%SUV max and iterative adaptive threshold (Z = -0.48, p = 0.699). However, using the non-BPL algorithm, the measurement errors of 42%SUV max and iterative adaptive delineation methods were 16.70%, 10.77%, 26.00%, 30.00%, 61.82%, 113.33%, and -7.70%, -9.00%, -8.73%, -5.20%, -12.91%, 38.33% respectively. The MTVs measurement accuracy of iterative adaptive was significantly better than that of the 42%SUV max threshold (Z = -2.24, p = 0.026). The iterative adaptive and 42%SUV max threshold methods had excellent interobserver reliability (ICCs=1.00 for all of six spheres) for MTVs measurement.Conclusion BPL reconstruction algorithm can improve the accuracy of MTVs measurements, especially for small lesions. In the case of using non-BPL methods, the iterative adaptive delineation method should be adopted to improve the accuracy of MTVs measurements.

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“…[21]. Currently, various automated methods are used to quantitatively estimate FDG uptake: fixed SUV threshold (e.g., SUV2.50), percentage threshold of SUVmax, gradient-based threshold, and background-related threshold [37]. New volumetric quantification methods such as: percentage of lung volume with increased metabolic activity (“%SUV-high”) and average metabolic activity in the lung (“SUVmean”) could be helpful for evaluating small lung changes.…”

Section: Discussionmentioning

confidence: 99%

Hybrid Imaging in Head and Neck Sarcoidosis

Milojevic

Tadić

Šobić-Šaranović

et al. 2019

JCM

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To determine the prevalence of head and neck sarcoidosis (HNS) and evaluate the role of hybrid molecular imaging in HNS. Between 2010 and 2018, 222 patients with chronic sarcoidosis and presence of prolonged symptoms of active disease were referred to FDG PET/CT. Active disease was found in 169 patients, and they were all screened for the presence of HNS. All patients underwent MDCT and assessment of the serum ACE level. Follow-up FDG PET/CT examination was done 19.84 ± 8.98 months after the baseline. HNS was present in 38 out of 169 patients. FDG uptake was present in: cervical lymph nodes (38/38), submandibular glands (2/38), cerebrum (2/38), and bone (1/38). The majority of patients had more than two locations of disease. After FDG PET/CT examination, therapy was changed in most patients. Fourteen patients returned to follow-up FDG PET/CT examination in order to assess the therapy response. PET/CT revealed active disease in 12 patients and complete remission in two patients. Follow-up ACE levels had no correlation with follow-up SUVmax level (ρ = −0.18, p = 0.77). FDG PET/CT can be useful in the detection of HNS and in the evaluation of the therapy response. It may replace the use of non-purposive mounds of insufficiently informative laboratory and radiological procedures.

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Comparison of different automated lesion delineation methods for metabolic tumor volume of 18F-FDG PET/CT in patients with stage I lung adenocarcinoma

Abstract: Supplemental Digital Content is available in the text

Cited by 21 publications

References 39 publications

Metabolic Tumour Volume Is Prognostic in Patients with Non-Small-Cell Lung Cancer Treated with Stereotactic Ablative Radiotherapy

Metabolic Tumour Volume Is Prognostic in Patients with Non-Small-Cell Lung Cancer Treated with Stereotactic Ablative Radiotherapy

The Impact of Bayesian Penalized Likelihood Reconstruction Algorithm on Quantitative Accuracy of Positron Emission Tomography Volumetric Measurements

Hybrid Imaging in Head and Neck Sarcoidosis

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