Comparison of different dose regimens of enoxaparin in deep vein thrombosis therapy in pregnancy

Abstract

Enoxaparin can be used safely in DVT therapy during pregnancy. Our results indicate that therapy consisting of a single daily dose of 1.5 mg/kg enoxaparin is as effective as twice-daily administration.

Anticoagulant therapy for venous thromboembolism during pregnancy: a systematic review and a meta‐analysis of the literature

“…Among the selected studies, 17 were written in English [19,21–36] and one in German [20]. The corresponding authors of 11 of the selected studies were contacted, with the aim of obtaining missing information, and six authors kindly provided the requested data.…”

“…Among the studies published as full articles, we further excluded one article because no antithrombotic therapy was used, seven because they included £ 10 patients, two because no data on follow-up were provided, and six because data on patients treated for acute VTE were not distinguishable from data on women receiving antithrombotic prophylaxis. Thus, a total of 15 full articles [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] and three abstracts [34][35][36] were eligible for inclusion in our systematic review (Fig. 1).…”

“…According to the Newcastle-Ottawa scale, no studies were of high quality and four studies were of medium quality [25,27,30,33]. Eight studies specified that the diagnosis of VTE was made with imaging techniques [20,21,23,25,26,28,32,33], two studies defined the diagnosis of recurrent VTE [20,32], and only one study used the classical definition of PPH to describe postpartum hemorrhages [30].…”

Cardiovascular Management in Pregnancy

“…36 Given their equivalent efficacy and safety, the lower dose may be more cost-effective, but this has not been studied systematically. Neither the American College of Obstetrics and Gynecology nor 37 In contrast to prophylactic dosing, therapeutic dosing of LMWH is weight based. The more common LMWHs available in the United States, enoxaparin and dalteparin, are administered every 12 hours.…”

Anticoagulant therapy for venous thromboembolism during pregnancy: a systematic review and a meta-analysis of the literature: a reply to a rebuttal

“…Regrettably, among studies selected for our meta-analysis, information about epidural anesthesiology was scarce. In only two papers did the authors describe the protocol used for epidural anesthesia: regional anesthesia was avoided until at least 12 h after the last dose of low-molecular-weight heparin (LMWH), which in one study was reduced to a prophylactic dose on the day prior to induction of labour; LMWH was subsequently re-administrated after 3 or 4 h after catheter removal [1,2]. In three other studies the authors reported that women did not suffer from epidural hemorrhages, but information about the anesthesiologic procedure was not provided [3][4][5].…”