We present a comparative study of three optical sensing platforms based on surface plasmon resonance (SPR) in plastic optical fibers (POFs). The proposed sensors consist of a D–shaped POF sensing area, where the exposed core is covered by a photoresist layer, used as intermediate layer between the fiber’s core and the metal (gold) film. The photoresist deposited on the exposed core in the D–shaped POF region, is pivotal in order to improve the performances of the sensor in terms of sensitivity. In particular, we have compared the performances of three different buffer layers based on the following photoresist: Microposit SU-8 3005, Microposit S1813 before and after the expiry date.