Comparison of different uncoated and starch-coated superparamagnetic iron oxide nanoparticles: Implications for stem cell tracking

Elkhenany, Hoda; Elkodous, M. Abd; Ghoneim, Nehal I.; Ahmed, Toka A.; Ahmed, Sara Atito Ali; Mohamed, Ihab K.; El‐Badri, Nagwa

doi:10.1016/j.ijbiomac.2019.10.031

Cited by 51 publications

(12 citation statements)

References 66 publications

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“…CoxNi 1 -xFe 2 O 4 is considered to have good magnetic properties, but the results show that both CoxNi1-xFe 2 O 4 and its ST-coated form caused a significant decrease in the proliferation rate. 33 The authors believe that this result may be related to the cytotoxic effect of nickel. 33 Ren et al demonstrated that cynomolgus MSCs (cMSCs) proliferation was reduced in passage 5 and passage 6 generations after 20 μg/mL MIRB was used to label cMSCs.…”

Section: Impact On Cell Proliferationmentioning

confidence: 97%

“…33 The authors believe that this result may be related to the cytotoxic effect of nickel. 33 Ren et al demonstrated that cynomolgus MSCs (cMSCs) proliferation was reduced in passage 5 and passage 6 generations after 20 μg/mL MIRB was used to label cMSCs. 98 The mechanisms involved in these differences in cell proliferation after labelling with different SPIONs are still not clear at present.…”

Section: Impact On Cell Proliferationmentioning

confidence: 97%

“…Elkhenany et al 33 Embedding or coupling drugs into SPIONs can effectively solve the problems of poor solubility, limited stability, fast metabolism and adverse side effects. Therefore, some drug-loaded SPIONs are used in the field of tumor treatment.…”

mentioning

confidence: 99%

“…Higher migration capacity was reported after treating cells with ST-Fe 2 O 3 and ST-Fe 3 O 4 . 33 This result can be attributed to higher energy needs of cells, either to support migration activity itself or to resist the cytotoxic effects caused by SPIONs.…”

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confidence: 99%

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Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

Wu¹,

Hu²,

Wang³

et al. 2021

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated and applied in the field of biomedicine due to their excellent superparamagnetic properties and reliable traceability. However, with the optimization of core composition, shell types and transfection agents, the cytotoxicity and metabolism of different SPIONs have great differences, and the labeled cells also show different cellular behaviors. Therefore, a holistic review of the construction and application of SPIONs is desired. This review focuses the advances of SPIONs in the field of biomedicine in recent years. After summarizing the toxicity of different SPIONs, the uptake, distribution and metabolism of SPIONs in vitro were discussed. Then, the regulation of labeled-cells behavior is outlined. Furthermore, the major challenges in the optimization process of SPIONs and insights on its future developments are proposed.

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Section: Impact On Cell Proliferationmentioning

confidence: 97%

Section: Impact On Cell Proliferationmentioning

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

Wu¹,

Hu²,

Wang³

et al. 2021

IJN

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“…So far, SPIOs are the only commercial NPs, several formulations of which have already been approved by the Food and Drug Administration and have been regulated for clinical applications (Wang et al, 2013). MSCs labeled by SPIO NPs can be tracked by MRI, providing a (Li et al, 2013;Bull et al, 2014;Guldris et al, 2017;Xie et al, 2019;Elkhenany et al, 2020). However, MSCs lack phagocytic capacity, and the surface charge of SPIO NPs are negative, which is a similar charge to that of the cellular membrane.…”

Section: Superparamagnetic Iron Oxide Nanoparticlesmentioning

confidence: 99%

Nanoparticles for Stem Cell Tracking and the Potential Treatment of Cardiovascular Diseases

Huang

Hé

et al. 2021

Front. Cell Dev. Biol.

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Stem cell-based therapies have been shown potential in regenerative medicine. In these cells, mesenchymal stem cells (MSCs) have the ability of self-renewal and being differentiated into different types of cells, such as cardiovascular cells. Moreover, MSCs have low immunogenicity and immunomodulatory properties, and can protect the myocardium, which are ideal qualities for cardiovascular repair. Transplanting mesenchymal stem cells has demonstrated improved outcomes for treating cardiovascular diseases in preclinical trials. However, there still are some challenges, such as their low rate of migration to the ischemic myocardium, low tissue retention, and low survival rate after the transplantation. To solve these problems, an ideal method should be developed to precisely and quantitatively monitor the viability of the transplanted cells in vivo for providing the guidance of clinical translation. Cell imaging is an ideal method, but requires a suitable contrast agent to label and track the cells. This article reviews the uses of nanoparticles as contrast agents for tracking MSCs and the challenges of clinical use of MSCs in the potential treatment of cardiovascular diseases.

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Temperature influence on NiFeMo nanoparticles magnetic properties and their viability in biomedical applications

et al. 2023

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NiFeMo alloy nanoparticles were synthesized by co-precipitation in the presence of organic additives. Nanoparticles thermal evolution shows that there is a significant increase in the average size (from 28 to 60 nm), consolidating a crystalline structure of the same type as the Ni 3 Fe phase but with lattice parameter a = 0.362 nm. Measurements of magnetic properties follow this morphological and structural evolution increasing saturation magnetization (Ms) by 578% and reducing remanence magnetization (Mr) by 29%. Cell viability assays on as-synthesized revealed that nanoparticles (NPs) are not cytotoxic up to a concentration of 0.4 μg/mL for both non-tumorigenic (fibroblasts and macrophages) and tumor cells (melanoma).

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Comparison of different uncoated and starch-coated superparamagnetic iron oxide nanoparticles: Implications for stem cell tracking

Cited by 51 publications

References 66 publications

Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

Nanoparticles for Stem Cell Tracking and the Potential Treatment of Cardiovascular Diseases

Temperature influence on NiFeMo nanoparticles magnetic properties and their viability in biomedical applications

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