Comparison of direct and indicator-dilution measurements of flow rate and mean circulation time

Bate, H; Sirs, John A.

doi:10.1007/bf02477800

Cited by 9 publications

(2 citation statements)

References 15 publications

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“…21 Butanol's low molecular weight, its miscibility with blood plasma, and its passage through both right and left sides of the heart and the pulmonary capillary bed make it likely that butanol is homogenously dispersed through the blood being ejected into the aorta. 22 Simultaneous arterial indicator concentrations at the brain and the tail could differ, however, if the transit times from heart to these organs differed. In the present method, blood flow computation (equation 4) does not require knowledge of the concentrations of arterial blood at specific points in time but involves instead the total amount of indicator withdrawn into the syringe over the 10 second experimental period (Qs(T)).…”

Section: Discussionmentioning

confidence: 99%

Regional brain blood flow in the conscious gerbil.

Uitert¹,

Levy²

1978

Stroke

130

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SUMMARY Regional brain blood flow was determined in 23 awake, unparalyzed gerbils with a simplified indicator-fractionation technique. The use of intravenous "C-butanol, an indicator that is freely diffusible into the brain, eliminated the need for repetitive sampling of arterial and cerebral venous blood and reduced the period of indicator circulation to 10 seconds. Gerbils spontaneously breathing room air (Paco 2 = 32 ± I (SE) mm Hg) had blood flows in whole cerebrum, cerebellum, and brainstem of 102 ± 4, 93 ± 5, and 114 ± 6 ml/lOOgm/min respectively. Cerebral blood flow increased linearly with elevations in Paco, (r = 0.969) and averaged 3.14 ± 0.17 ml/lOOgm/min per mm Hg increase in Paco 2 . Interpolated cerebral blood flow at a Paco, of 40 mm Hg was 127 ± 2 ml/lOOgm/min. This technique is easy and convenient to use, involves no intracrania! surgery, requires steady state conditions for only 10 seconds, and minimizes blood loss in small animals. In more discrete brain regions a less volatile indicator is needed.

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Section: Discussionmentioning

confidence: 99%

Regional brain blood flow in the conscious gerbil.

Uitert¹,

Levy²

1978

Stroke

130

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“…This finding confirms the results of direct measurements of myocardial blood content before and after dipyridamole in pig (Winbury et al, 1971) and guinea-pig hearts (Virtanen, 1974). The good correlation between the dye dilution curve analysis and direct flow measurements (r = 0-83) is also evidence of good mixing of the dye and thus of the validity of the information provided by the curves (Bate & Sirs, 1974).…”

Section: Discussionmentioning

confidence: 75%

Flow‐volume relations in coronary circulation and distribution of coronary flow into nutritional and non‐nutritional compartments

Virtanen

Järvinen

Alitalo

et al. 1983

Clinical Physiology

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Simultaneous assessment of coronary flow and flow-volume relation makes it possible to evaluate the dilatatory responses of coronary vasculature. A new set up of methods for investigation of the coronary circulation was employed to study the nature of the coronary flow and volume responses to dipyridamole in dogs. The turnover rate of coronary blood, the reciprocal value of the mean transit time, can be accurately determined by computer simulation analysis of coronary dye dilution curves. After intravenous dipyridamole (0.5 mg/kg) both coronary turnover rate and electromagnetically assessed blood flow were observed to increase in parallel and to the same degree (+55%). This indicates that no increase in the coronary vascular volume and, accordingly, no significant overall coronary dilatation takes place. The effective coronary blood flow in relation to the myocardial oxygen consumption, i.e. the nutritional flow, and the myocardial oxygen consumption decreased by 25% concomitant to a corresponding fall in myocardial oxygen requirements. Thus, the increase in total coronary flow after dipyridamole is useless for myocardial metabolism, and may properly be denoted as luxury perfusion or throughput flow.

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Dispersion of solutes during blood flow through curved tubes

Patel

Sirs

1983

Med. Biol. Eng. Comput.

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Comparison of direct and indicator-dilution measurements of flow rate and mean circulation time

Cited by 9 publications

References 15 publications

Regional brain blood flow in the conscious gerbil.

Regional brain blood flow in the conscious gerbil.

Flow‐volume relations in coronary circulation and distribution of coronary flow into nutritional and non‐nutritional compartments

Dispersion of solutes during blood flow through curved tubes

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