Comparison of dispersion and actuation properties of vortex and synthetic antiferromagnetic particles for biotechnological applications

Leulmi, Selma; Joisten, Hélène; Dietsch, T.; Iss, Cécile; Morcrette, Mélissa; Auffret, S.; Sabon, Philippe; Diény, B.

doi:10.1063/1.4821854

Cited by 34 publications

(45 citation statements)

References 11 publications

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“…S2), minimizing aggregation due to particle-particle interactions. 27 In addition, synthesis through optical lithography results in a uniform composition, size and shape distribution. The particles are a two-dimensional structure designed a with spin-vortex ground state leading to zero next moment to minimize the aggregation due to particle-particle interactions and have a higher saturation magnetization to induce a higher mechanical force as compared to other particles used for magnetization therapies.…”

Section: Resultsmentioning

confidence: 99%

Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

Cheng

Muroski

Petit

et al. 2016

Journal of Controlled Release

130

109

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Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field using magnetic particles has not yet been demonstrated. To-date, induced cancer cell death via the oscillation of nanoparticles under a low frequency magnetic field has only been observed in-vitro. In this report, we demonstrate the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. The internalized nanomagnets align themselves to the plane of the rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure inducing programmed cell death. In vivo, the magnetic field treatment successfully reduces the brain tumor size and increases the survival rate of mice bearing intracranial glioma xenografts, without adverse side effects. This study demonstrates the novel approach of controlling magnetic particles for treating malignant glioma that should be applicable to treat a wide range of cancers.

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Section: Resultsmentioning

confidence: 99%

Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

Cheng

Muroski

Petit

et al. 2016

Journal of Controlled Release

130

109

View full text Add to dashboard Cite

show abstract

“…Perpendicularly magnetized materials have gained technological prominence because they offer large data retention times and fast domain wall speeds 6 for data storage devices, 7 high spin-orbit coupling effects for ultra low power logic and memory elements, [8][9][10] and the possibility of novel logic applications through interacting multilayers via antiferromagnetic (AF) interlayer exchange coupling. 11 While the behavior of magnetized permalloy vortex particles in a fluid has been investigated 12 because of interest in their potential as a novel cancer therapy, 13 the magnetic response of lithographically defined, perpendicularly magnetized particles 14 with antiferromagnetic interlayer coupling between magnetic layers, in a fluid and under an applied field has still not been fully characterized.…”

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confidence: 99%

The mechanical response in a fluid of synthetic antiferromagnetic and ferrimagnetic microdiscs with perpendicular magnetic anisotropy

Vemulkar

Welbourne

Mansell

et al. 2017

Applied Physics Letters

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In this article, we demonstrate the magneto-mechanic behavior in a fluid environment of perpendicularly magnetized microdiscs with antiferromagnetic interlayer coupling. When suspended in a fluid and under the influence of a simple uniaxial applied magnetic field sequence, the microdiscs mechanically rotate to access the magnetic saturation processes that are either that of the easy axis, hard axis, or in-between the two, in order to lower their energy. Further, these transitions enable the magnetic particles to form reconfigurable magnetic chains, and transduce torque from uniaxial applied fields. These microdiscs offer an attractive platform for the fabrication of fluid based micro- and nanodevices, and dynamically self assembled complex architectures.

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“…11,12 Careful optimization of the magnetic properties of the particles for the desired application is crucial. 13,14 This paper is dedicated to the optimization of the magnetic properties of particles for the genre of applications listed above.…”

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confidence: 99%

“…Furthermore, a high susceptibility may also lead to particles staying agglomerated once an applied field is removed. 13,14 The ability to vary the total moment of the particle without varying its remanent state and other key magnetic properties is also desirable. A sharp switch to full magnetization at a desired applied field H SW would allow efficient access to the saturation moment of the particle, and the ability to tune H SW would allow greater flexibility for applications such as sorting and purification.…”

mentioning

confidence: 99%

“…It has been shown that such particles can agglomerate irreversibly under applied field. 13 One method to decrease the susceptibility is to couple vortex discs together via RKKY interactions to create a SAF. The added coupling has the effect of causing the hysteresis loop to look similar to the superparamagnetic loop, but allows the low field susceptibility to be controlled through the number and thickness of the magnetic layers.…”

mentioning

confidence: 99%

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Highly tunable perpendicularly magnetized synthetic antiferromagnets for biotechnology applications

Vemulkar

Mansell

Petit

et al. 2015

Applied Physics Letters

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Magnetic micro and nanoparticles are increasingly used in biotechnological applications due to the ability to control their behavior through an externally applied field. We demonstrate the fabrication of particles made from ultrathin perpendicularly magnetized CoFeB/Pt layers with antiferromagnetic interlayer coupling. The particles are characterized by zero moment at remanence, low susceptibility at low fields, and a large saturated moment created by the stacking of the basic coupled bilayer motif. We demonstrate the transfer of magnetic properties from thin films to lithographically defined 2 m particles which have been lifted off into solution. We simulate the minimum energy state of a synthetic antiferromagnetic bilayer system that is free to rotate in an applied field and show that the low field susceptibility of the system is equal to the magnetic hard axis followed by a sharp switch to full magnetization as the field is increased. This agrees with the experimental results and explains the behaviour of the particles in solution.

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Comparison of dispersion and actuation properties of vortex and synthetic antiferromagnetic particles for biotechnological applications

Cited by 34 publications

References 11 publications

Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

The mechanical response in a fluid of synthetic antiferromagnetic and ferrimagnetic microdiscs with perpendicular magnetic anisotropy

Highly tunable perpendicularly magnetized synthetic antiferromagnets for biotechnology applications

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