Comparison of dual trigger with combination Gn<scp>RH</scp> agonist and <scp>hCG</scp> versus <scp>hCG</scp> alone trigger of oocyte maturation for normal ovarian responders

Zhou, Xingyu; Guo, Pingping; Chen, Xin; Ye, De-Sheng; Liu, Yudong; Chen, Shiling

doi:10.1002/ijgo.12457

Cited by 30 publications

(39 citation statements)

References 22 publications

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“…In addition, a GnRHa trigger can also activate the GnRH receptors on granulosa cells, which may regulate ovulation 16 . Our results are consistent with many studies of the use of dual trigger for oocyte maturation in normal responders 1,11,12,17 . Though several studies showed that there was no signi cant difference in the number of MII oocytes and the number of 2PN oocytes with the use of dual trigger in comparison to hCG alone.…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, much higher abortion rate was demonstrated in the dual trigger group (17.95% vs. 10.34%), although this difference was not statistically signi cant. Our results agreed with Zhou who reported no difference between the two study groups regarding the implantation rate, clinical pregnancy rate and live birth rate in a retrospective cohort study including a big sample size (220 patients in dual trigger group and 110 control patients) 12 . In addition, two randomized controlled trial (RCT) studies by Shymaa and Alleyassin explored the effect of dual trigger for oocyte maturation on the pregnant outcome in fresh embryo transfer cycles in normal responders 17,20 .…”

Section: Discussionsupporting

confidence: 92%

“…Some studies reported signi cantly improved ongoing pregnancy rate and live birth rate in fresh cycles for the dual trigger group compared with the hCG trigger group in normal responders 1,11 . By contrast, several studies demonstrated that dual trigger of oocyte maturation was not associated with any change in the live birth rate in fresh cycles for normal ovarian responders 12,13 . However, these researches did not focus on the cumulative live birth rate which provided an all-inclusive success rate for assisted reproductive technology (ART).…”

Section: Introductionmentioning

confidence: 88%

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The Effect of Dual Trigger With GnRH Agonist and hCG on Cumulative Live-Birth Rate For Normal Responders in GnRH-Antagonist Cycles

Gao

Wang

et al. 2021

Preprint

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It has been widely acknowledged that the dual triggering for final oocyte maturation with a combination of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) improve clinical outcomes in high responders during IVF-ICSI GnRH-antagonist cycles. However, it remains elusive whether this dual trigger is also benifical to the normal responders. The aim of this study was to investigate this issue. In the present study, we retrospectively analysed the data generated from a total of 469 normal responders from 1st January to 31st December 2017 and final oocyte maturation was performed with dual trigger with GnRH agonist combined hCG (n=270) or hCG alone (n=199). All the patients were followed up for three years. Cumulative live birth rate was calculated as the first live birth achieved after all cycles having an embryo transfer (fresh cycles as well as thawing cycles) among both groups. Subjects in the dual trigger group achieved a slightly higher number of oocytes retrieved (11.24 vs. 10.24), higher number of two-pronuclear embryo (2PN) (8.37 vs.7.67) and a higher number of embryos available (4.45 vs.4.03). But the cumulative live birth rate, an all-inclusive success rate for assisted reproductive technology, was similar between the two groups (54.07% vs.59.30%). This study showed that the dual trigger was not superior to only hCG trigger for normal responders in GnRH antagonist cycles in terms of cumulative live birth rate.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

The Effect of Dual Trigger With GnRH Agonist and hCG on Cumulative Live-Birth Rate For Normal Responders in GnRH-Antagonist Cycles

Gao

Wang

et al. 2021

Preprint

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“…Some studies reported a significantly improved ongoing pregnancy rate and live-birth rate in fresh-embryo transfer (FET) cycles for a dual-trigger group compared with the hCG-trigger group in normal responders (1,11). By contrast, several studies have demonstrated that dual trigger of oocyte maturation was not associated with a change in the live-birth rate in FET cycles for normal ovarian responders (12,13). However, those studies did not focus on the cumulative live-birth rate, which provides an all-inclusive success rate for assisted reproductive technology (ART).…”

Section: Introductionmentioning

confidence: 99%

Effect of a “Dual Trigger” Using a GnRH Agonist and hCG on the Cumulative Live-Birth Rate for Normal Responders in GnRH-Antagonist Cycles

Gao

Wang

et al. 2021

Front. Med.

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“Dual triggering” for final oocyte maturation using a combination of a gonadotropin-releasing hormone agonist (GnRHa) and human chorionic gonadotropin (hCG) can improve clinical outcomes in high responders during in vitro fertilization–intracytoplasmic sperm injection (IVF–ICSI) GnRH-antagonist cycles. However, whether this dual trigger is also beneficial to normal responders is not known. We retrospectively analyzed the data generated from 469 normal responders from 1 January to 31 December 2017. The final oocyte maturation was undertaken with a dual trigger with a GnRHa combined with hCG (n = 270) or hCG alone (n = 199). Patients were followed up for 3 years. The cumulative live-birth rate was calculated as the first live birth achieved after all cycles having an embryo transfer (cycles using fresh embryos and frozen–thawed embryos) among both groups. Women in the dual-trigger group achieved a slightly higher number of oocytes retrieved (11.24 vs. 10.24), higher number of two-pronuclear (2PN) embryos (8.37 vs. 7.67) and a higher number of embryos available (4.45 vs. 4.03). However, the cumulative live-birth rate and the all-inclusive success rate for assisted reproductive technology was similar between the two groups (54.07 vs. 59.30%). We showed that a dual trigger was not superior to a hCG-alone trigger for normal responders in GnRH-antagonist cycles in terms of the cumulative live-birth rate.

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“…Although the effectiveness of dual trigger on uterine receptivity is still controversial as most recent study by Zhou et al . demonstrated that there are no differences in pregnancy outcomes between the dual and hCG only triggers 68 . Our results demonstrated that the dual trigger with low dose of buserelin and hCG tended to improve blastocyst implantation and endometrial steroid signalling (Supplemental Fig.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of uterine receptivity after gonadotropin releasing hormone agonist administration as an oocyte maturation trigger: a rodent model

Ezoe¹,

Murata²,

Yabuuchi³

et al. 2019

Sci Rep

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In natural cycle or minimal stimulation cycle IVF, buserelin acetate (buserelin), a gonadotropin-releasing hormone agonist, is often used as a maturation trigger; however, its effect on pregnancy outcomes remains unclear. Therefore, in the present study, we compared uterine receptivity in buserelin-administered mice with that in human chorionic gonadotropin (hCG)-administered mice during the peri-implantation period. Implantation, decidualisation, and term-pregnancy were impaired following hCG, but not buserelin administration. hCG stimulated the synthesis and secretion of progesterone and oestradiol, whereas ovarian steroidogenesis in the buserelin-treated group was comparable with that in the control group. Furthermore, similar to the observation in controls, the buserelin-treated group exhibited activation of progesterone receptor signalling and inhibition of oestrogen receptor signalling in the endometrial epithelium on the day of implantation. However, epithelial progesterone signalling was not detected, and a high expression of genes downstream to oestrogen was observed on day 4 following hCG administration. These results suggest that buserelin administration does not impact uterine receptivity as it did not affect ovarian steroidogenesis and endometrial steroid signalling. Therefore, buserelin is preferred as an oocyte maturation trigger to optimise uterine receptivity during treatments involving timed intercourse, intrauterine insemination, or fresh embryo transfer following in vitro fertilisation.

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Comparison of dual trigger with combination GnRH agonist and hCG versus hCG alone trigger of oocyte maturation for normal ovarian responders

Abstract: Dual trigger of oocyte maturation was not associated with any change in the live delivery rate but was associated with improvements in the quantity and quality of embryos; it could optimize pregnancy outcomes for normal ovarian responders.

Cited by 30 publications

References 22 publications

The Effect of Dual Trigger With GnRH Agonist and hCG on Cumulative Live-Birth Rate For Normal Responders in GnRH-Antagonist Cycles

The Effect of Dual Trigger With GnRH Agonist and hCG on Cumulative Live-Birth Rate For Normal Responders in GnRH-Antagonist Cycles

Effect of a “Dual Trigger” Using a GnRH Agonist and hCG on the Cumulative Live-Birth Rate for Normal Responders in GnRH-Antagonist Cycles

Evaluation of uterine receptivity after gonadotropin releasing hormone agonist administration as an oocyte maturation trigger: a rodent model

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