“…There have been seven systematic reviews examining methods of TAC in the OA over the last 10 years [ 539 , 542 , 570 , 573 , 574 , 575 , 576 , 577 ] and three RCTs [ 559 , 578 , 579 ]. The overall strength of the reported outcomes is low due to the small number and poor quality of comparative observational studies.…”