Comparison of Effect of Clonidine Added to Bupivacaine-Fentanyl Mixture on the Quality of Spinal Anaesthesia and Peri-Op Analgesia with Bupivacaine-Fentanyl or Bupivacaine-Clonidine Mixture in Major Orthopaedic Lower Limb Surgeries

Abstract

Introduction:With side effects of central neuroaxial opioids or of high dose intrathecal clonidine in combination with bupivacaine in spinal anaesthesia, my study is to ascertain if small dose of clonidine when added to bupivacaine-fentanyl mixture improves spinal anaesthesia, without producing side effects, as compared to bupivacaine-fentanyl or bupivacaineclonidine mixture. Methods: It's a prospective, double blinded randomised study of 90 ASA grade I-II patients, aged between 20-60 yrs, of either sex, weighing between 40-70 kgs, scheduled for major orthopaedic surgeries. Patients were randomly divided into 3 groups of 30 patients each as Group I (BCF): Bupivacaine 0.5%H 2.6ml + Fentanyl 20mcg + Clonidine 30mcg Group II (BC): Bupivacaine 0.5%H 2.6ml + Clonidine 30mcg Group III (BF): Bupivacaine 0.5%H 2.6ml + Fentanyl 20mcg Duration of sensory and motor blockade and effective analgesia mean time till two segment regression, haemodynamic profile, post-op pain and analgesia requirement were recorded. Results: The duration of sensory and motor blockade, effective analgesia and mean time till two segment regression were significantly longer in group BCF as compared to group BC (P -0.002) and in group BC as compared to group BF (P -0.01). The incidence of intra-op pain and requirement of postop analgesia in the first 24 hours was significantly more in group BF as compared to other groups (P-0.01). Conclusion: Low dose Clonidine when added to Bupivacaine-Fentanyl mixture improves the quality of peri-op analgesia without significant side effects.