Comparison of Effects of Leukocyte-Rich and Leukocyte-Poor Platelet-Rich Plasma on Pain and Functionality in Patients With Lateral Epicondylitis

Yerlikaya, Melek

doi:10.5606/archrheumatol.2018.6336

Cited by 50 publications

(31 citation statements)

References 14 publications

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“…Hanish et al did not find any significant differences between leukocyte-poor (LP)-PRP and LR-PRP in treatment of Achilles tendinopathy in VISA-A and VAS [103]. Further, Yerlikali et al showed no significant differences in pain, functional parameters, and inflammatory reaction between LR-PRP and LP-PRP in patients with lateral epicondylitis [104]. Riboh et al performed a meta-analysis including six RCTs and three prospective comparative studies comparing efficacy of leukocyte concentration in OA treatment.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

Tramś

Kulinski

Kozar-Kamińska

et al. 2020

Life

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In recent years, the interest in biological treatment of knee lesions has increased, especially the application of platelet-rich plasma is of particular note. The number of articles evaluating platelet-rich plasma (PRP) efficacy in the recovery of knee disorders and during knee surgery has exponentially increased over the last decade. A systematic review with meta-analyses was performed by assessing selected studies of local PRP injections to the knee joint. The study was completed in accordance with 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A multistep search of PubMed, Embase, Cochrane Database of Systematic Reviews, and Clinicaltrials.gov was performed to identify studies on knee surgery and knee lesion treatment with PRP. Of the 4004 articles initially identified, 357 articles focusing on knee lesions were selected and, consequently, only 83 clinical trials were analyzed using the revised Cochrane risk-of-bias tool to evaluate risk. In total, seven areas of meta-analysis reported a positive effect of PRP. Among them, 10 sub-analyses demonstrated significant differences in favor of PRP when compared to the control groups (p < 0.05). This study showed the positive effects of PRP, both on the recovery of knee disorders and during knee surgery; however further prospective and randomized studies with a higher number of subjects and with lower biases are needed.

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Section: Discussionmentioning

confidence: 99%

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

Tramś

Kulinski

Kozar-Kamińska

et al. 2020

Life

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“…Hilber et al [50] reported that leukocyte-reduced PRP stimulates the proliferation of tenocytes and Zhang et al [51] demonstrated that proliferation of tendon stem cells cultured in leukocyte-rich was significantly decreased and tendon stem cells cultured in leukocyte-poor PRP produced more collagen and formed tendon-like tissue. However, these were in vitro studies and clinical studies did not show any significant difference between leukocyte-rich and leukocyte-poor PRPs [53, 54].…”

Section: Discussionmentioning

confidence: 99%

Effect of platelet-rich plasma on the degenerative rotator cuff tendinopathy according to the compositions

Yeo¹,

Noh²,

Ha³

et al. 2019

J Orthop Surg Res

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BackgroundThere are controversies about platelet-rich plasma (PRP) as an established treatment option for rotator cuff (RC) tendinopathy. The purpose of the study was to find the relation of cellular component with clinical efficacy in RC tendinopathy and to find the composition of PRP in treating RC tendinopathy.MethodsA total 30 patients were recruited and divided into PRP and control groups. In the PRP group, 2 ml of PRP solution was injected to the hypoechoic lesion of degenerative supraspinatus via 22-gauge syringe with peppering technique. Patients in the control group were taught rotator cuff strengthening exercises. American Shoulder and Elbow Surgeons (ASES), Constant-Murley score, and numeric rating scale (NRS) were measured before, 6 weeks after, 12 weeks after, and 24 weeks after the procedure. PRP compositions were analyzed using the 1 ml of PRP solution.ResultsLinear regression analysis showed no significant difference of ASES and Constant-Murley scores between the groups at 6 weeks (P = 0.582 and 0.258) and at 12 weeks (P = 0.969 and 0.795) but showed a significant difference at 24 weeks (P = 0.050 and 0.048). Independent t test showed significant group difference of NRS at 6 weeks (P = 0.031) but not at 12 and 24 weeks (P = 0.147 and 0.935). 5.19 pg/ml in IL-1β and 61.79 μg/ml in TGF-β1 were acquired as cutoff values to predict meaningful improvement. The PRP subgroup above IL-1β or TGF-β1 cutoff value showed significant differences in all clinical outcomes compared with the exercise group while the PRP subgroup below the cutoff value showed no significant differences in linear regression analysis.ConclusionsOur study can help to find the optimal PRP condition and to enhance the effect of PRP on RC tendinopathy.Trial registrationAll the patients were registered in our Institutional Ethics Committee (approval number 2014-05-009).

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“…It is hypothesised that these side effects are caused by the catabolic potential induced by the interleukin-1β (IL-1β) and the tumour necrosis factor-α, and their subsequent stimulatory effects on the nuclear factor κB signalling pathway. Furthermore, it is theorised that high concentrations of leucocytes in PRP may intensify MMP expressions and therefore cause excessive degradation of the extracellular matrix tissue and thus inhibit healing [5,33,34]. Conversely, though, tissue regeneration is equally reliant on the interactions and cross-talk between surrounding cells and leucocytes.…”

Section: Leucocytes: Lr-prp and Lp-prpmentioning

confidence: 99%

Effects of platelet-rich plasma and platelet-poor plasma on human dermal fibroblasts

et al. 2018

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Platelet Rich Plasma is an autologous and safe blood product containing a high concentration of platelets and leucocytes, in a small volume of plasma. Platelets, growth factors, leucocytes and plasma are fundamental fibroblast proliferation agents. The leucocytes' plasticity, reparative qualities, their cross-talk between cells and capacity to orchestrate such diverse outcomes is receiving a considerable commendation. This succession enables fibroblast cells to migrate and proliferate into the wound's surrounding tissue and subsequently deposit granulation tissue to facilitate minimal scarring and also for anti-ageing benefits. The focus on leucocytes in tissue repair has enthused a new approach to tissue regeneration to form a new therapeutic modality, Immuno-Regenerative Medicine.

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Comparison of Effects of Leukocyte-Rich and Leukocyte-Poor Platelet-Rich Plasma on Pain and Functionality in Patients With Lateral Epicondylitis

Abstract: According to our study findings, lateral epicondylitis does not seem to affected either leukocyte-rich-PRP or leukocyte-poor-PRP on pain and function in the short term. Leukocyte concentration had no association with post-injection local inflammatory reactions.

Cited by 50 publications

References 14 publications

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

Effect of platelet-rich plasma on the degenerative rotator cuff tendinopathy according to the compositions

Effects of platelet-rich plasma and platelet-poor plasma on human dermal fibroblasts

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