2017
DOI: 10.4158/ep171804.or
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Comparison of Efficacy and Safety of Glargine and Detemir Insulin in the Management of Inpatient Hyperglycemia and Diabetes

Abstract: Objective Glargine and detemir insulin are the two most commonly prescribed basal insulin analogs for the ambulatory and inpatient management of diabetes. The efficacy and safety of basal insulin analogs in the hospital setting has not been established. Methods This observational study compared differences in glycemic control and outcomes in non-ICU patients with blood glucose (BG) >140 mg/dl who were treated with glargine or detemir, between 01/01/2012 and 09/30/2015 in two academic centers. Results Among… Show more

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Cited by 18 publications
(14 citation statements)
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“…Comorbidities and hospital complications were identified by ICD-9/10 codes generated during the hospitalization as previously described 12. ICD-9 codes generated during the hospital stay, but not present during admission, and laboratory data generated during the stay were used to calculate the rate of hospital-related complications, including: hypokalemia (<3 mmol/L), severe hypokalemia (<2.5 mmol/L), myocardial infarction, volume overload (pulmonary edema or congestive heart failure), need for mechanical ventilation, deep vein thrombosis, pulmonary thromboembolism, sepsis, and rhabdomyolysis.…”
Section: Methodsmentioning
confidence: 99%
“…Comorbidities and hospital complications were identified by ICD-9/10 codes generated during the hospitalization as previously described 12. ICD-9 codes generated during the hospital stay, but not present during admission, and laboratory data generated during the stay were used to calculate the rate of hospital-related complications, including: hypokalemia (<3 mmol/L), severe hypokalemia (<2.5 mmol/L), myocardial infarction, volume overload (pulmonary edema or congestive heart failure), need for mechanical ventilation, deep vein thrombosis, pulmonary thromboembolism, sepsis, and rhabdomyolysis.…”
Section: Methodsmentioning
confidence: 99%
“…Our sample size was based on an overall rate of hypoglycemia in the detemir group of 33.5% compared to 29% for the glargine group, with an alpha error rate of 0.05 and 80% power ( 16 ). To find this difference, a sample size of 1,659 patients per group was needed, for a total of 3,318 patients.…”
Section: Design and Methodsmentioning
confidence: 99%
“…Despite the breadth of comparative literature surrounding basal insulin therapy in the ambulatory care environment, there is a paucity of evidence comparing the safety and efficacy of glargine and detemir in hospitalized patients. Galindo et al ( 16 ) performed a retrospective database analysis of glargine and detemir use in hospitalized patients who had either type 1 or type 2 diabetes. No difference in average blood glucose values was noted between the two insulin cohorts throughout the hospital stay.…”
mentioning
confidence: 99%
“…There are a limited number of studies on head-to-head comparison of iDet and iGla in patients with T1D [4,5]. All the comparison studies conducted on patients with either T1D or type 2 diabetes (T2D) also used once-daily dosing of these two basal insulin analogues and demonstrated similar efficacy [5][6][7]. In the only available trial that compared once-versus twice-daily iDet in patients with T1D, the HbA1c at four months was 8.1 ±0.9 vs. 8.0 ±1.0% with once-and twice-daily iDet, respectively, with an adjusted between-group difference of 0.12%, showing noninferiority for once-daily dosing [8].…”
mentioning
confidence: 99%