Comparison of efficacy and safety of sublingual misoprostol with intracervical dinoprostone gel for cervical ripening in prelabour rupture of membranes after 34 weeks of gestation

Jha, Nivedita; Sagili, Haritha; Durairaj, Jayalakshmi; Lakshminarayanan, Subitha

doi:10.1007/s00404-014-3383-5

Cited by 62 publications

(5 citation statements)

References 14 publications

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“…A research from India has also found significant difference in the post-induction mean Bishop's score when PGE1 was administered vaginally, and our finding is in concordance with this observation [7]. Significantly less proportion of patients required augmentation of labour with oxytocin or ARM (46.3 vs 62.1 %), and this correlates with evidence from Pakistan where oral PGE1 was compared with intracervical PGE2 [4] and by Niveditha et al [8] in PPROM. Our study has showed significant proportion of mothers had shorter induction-to-delivery time in PGE1 group than PGE2 group.…”

Section: Discussionsupporting

confidence: 91%

“…Our study has showed significant proportion of mothers had shorter induction-to-delivery time in PGE1 group than PGE2 group. Similar observation has been found by Niveditha et al [8] when sublingual PGE1 was induced for PPROM after 34 weeks, and it has been shown to be more effective than intracervical PGE2. This finding is also in concordance with observation from Chaudhuri et al [9] when vaginal misoprostol was compared with PGE2.…”

Section: Discussionsupporting

confidence: 88%

“…However, Faucett et al [10] have concluded that there is no significant difference in caesarean rate between oral misoprostol and vaginal PGE2. Similar finding was also observed by Niveditha et al [8]. A study from Ludhiana which compared oral PGE1 and vaginal PGE2 found an increased incidence of caesarean rate in oral PGE1 group [11].…”

Section: Discussionsupporting

confidence: 87%

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Sublingual Misoprostol (PGE1) Versus Intracervical Dinoprostone (PGE2) Gel for Induction of Labour: A Randomized Control Trail

Veena¹,

Samal

Inbaraj

et al. 2015

J Obstet Gynecol India

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Background Prostaglandins are popular agents for induction of labour, owing to their dual action of cervical ripening and inducing uterine contractions. Sublingual misoprostol offers high efficacy as it bypasses first-pass metabolism. Researchers have proved that intracervical PGE1 is as effective as PGE2 except for increased caesarean rate and hyperstimulation. Limited knowledge is available on the efficacy of sublingual PGE1 and intracervical PGE2. This study was designed to compare the effectiveness of sublingual PGE1 with intracervical PGE2. Methods A randomized control trial was conducted in Bangalore Baptist Hospital, Bangalore. One hundred and ninety women with singleton, term pregnancy were equally divided into PGE1 and PGE2 groups, and primary outcome was measured. Results Post-induction mean Bishop's score in PGE1 group was statistically significant (t = 6.57, p \ 0.05).This study was conducted at Bangalore Baptist Hospital, Bellary Road, Hebbal, Bangalore, 560024 (Phone: 080-22024700). Sr. Dr. Veena Braganza is a missionary nun belonging to the Sisters of Charity which runs health centres in Goa and rural Karnataka. She did her DGO in Goa Medical College and served in various mission hospitals before she obtained DNB from Bangalore Baptist Hospital, Bangalore. She is passionate in reaching out to the poor with low-cost affordable yet safe and effective care. This PG thesis on PGE1 as promising agent was her special interest due to its low cost, and she herself used in limited resource settings. Hence, she conceptualized this trail to prove its efficacy scientifically. Her keen interest is VBAC to bring down cost of surgeries and obstetric care. She is currently involved in making health care accessible to migrant population in Goa and Karnataka. Braganza Veena is Medical Director and Consultant in Obstertics andThe Journal of Obstetrics and Gynecology of India (September-October 2016) 66(S1):S122-S128 DOI 10.1007/s13224-015-0820-8123 Conclusion Sublingual PGE1 is a better cervical ripening agent, faster and more effective, with a shorter inductionto-delivery interval as compared to intracervical PGE2. We also noted lower incidence of caesarean section and foetal distress with sublingual PGE1 compared to oral or vaginally administered PGE1.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

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Sublingual Misoprostol (PGE1) Versus Intracervical Dinoprostone (PGE2) Gel for Induction of Labour: A Randomized Control Trail

Veena¹,

Samal

Inbaraj

et al. 2015

J Obstet Gynecol India

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“…Patients receiving sublingual administration of misoprostol have shorter induction to active phase, induction to delivery time intervals and also require less oxytocin for augmentation than the patients in which intra cervical dinoprostone gel was administered. Similar to present study, Wing et [8][9][10][11] . However Zhang et al did not find significant difference in Induction to delivery interval in two groups [12] .…”

Section: Discussionsupporting

confidence: 90%

Sublingual misoprostol versus intracervical dinoprostone gel for induction of labour: A randomized trial

Polisetty¹,

Jaju²

2022

Int. J. Clin. Obstet. Gynaecol.

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Background: Sublingual misoprostol and intracervical dinoprostone gel are used for induction of labor. The aim of the study was to compare the efficacy and safety profile of sublingual misoprostol (PGE1) versus intracervical dinoprostone gel (PGE2) for induction of labor. Methods: 84 women with single live fetus as per inclusion and exclusion criteria for induction of labor were recruited for the study. Patients were randomized to receive either 50μg of misoprostol sublingually or dinoprostone gel (0.5mg) intracervically. Results: There was shorter induction to active phase, induction to delivery time intervals and less requirement of oxytocin augmentation in sublingual misoprostol group than intracervical dinoprostone gel group. Caesarean section rate is more in sublingual misoprostol group than intracervical dinoprostone gel group because of increased fetal distress in sublingual misoprostol group. Incidence of tachysystole was higher in sublingual misoprostol group than intracervical dinoprostone gel group. Perinatal outcome is better in intracervical dinoprostone group because of lesser side effects like tachysystole, fetal distress. Conclusions: Use of dinoprostone gel is a safe method for induction of labor.

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“…Recently, intravaginal dinoprostone have greatly replaced the off-label usage of intravaginal misoprostol. Keeping in mind the possible side effects of misoprostol and the costly issues of dinoprostone it would be crucial to investigate the effectiveness of other agents within this field of obstetric practice (6) .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Oral Propranolol plus Oxytocin Versus Oxytocin alone on Induction and Outcome of Labor

Sobhy¹,

Ali²,

Ahmed³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Labor is a state of uterine contractions having adequate frequency, duration, and strength resulting in cervical effacement and dilatation. Prolonged labor could cause maternal and neonatal medical issues and these unfavorable labor clinical outcomes are elevated in prolonged gestations in comparison with term pregnancies. The present study aimed to evaluate the effect of oral propranolol supplementary agent to oxytocin on Induction and Outcome of Labor and compare it with the control group (oxytocin alone). Patients and methods: This was a Randomized Controlled Clinical Trial which was conducted in Zagazig University Hospital and Zagazig General Hospital in the period between January 2021 and December 2021 to compare the efficacy of propranolol and oxytocin vs. oxytocin alone for induction of labor at 38-41 week gestational age. The study was conducted on 106 pregnant women; divided into two groups each group contain 53 pregnant women. Results: Duration of Latent Phase and Duration of 3 rd stage was significantly shorter among study group but there was no significance difference in duration of active phase and 2 nd stage between two groups. Dose of Oxytocin at which sufficient contractions occurred (3 contractions per 10 minutes) was significantly lower among the study group than the control group. Normal vaginal delivery was more frequent among the study group than among the control group: 41 cases (77.4%) versus 32 controls (60.4%). Cesarean section mode was less in the study group than the control group (p>0.05). Conclusion: Administration of oral propranolol combined with oxytocin during latent phase of labor is an effective agent in shortening the labor duration and decreasing the rate of cesarean section with no considerable side effects neither to the mother nor to her newborn has been recorded during the study.

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Comparison of efficacy and safety of sublingual misoprostol with intracervical dinoprostone gel for cervical ripening in prelabour rupture of membranes after 34 weeks of gestation

Abstract: Sublingual misoprostol and intracervical dinoprostone at the dose studied are equally efficacious in achieving spontaneous vaginal delivery, reduction in induction-delivery interval and in reducing the need for oxytocin, in women after 34 weeks gestation with rupture of membranes.

Cited by 62 publications

References 14 publications

Sublingual Misoprostol (PGE1) Versus Intracervical Dinoprostone (PGE2) Gel for Induction of Labour: A Randomized Control Trail

Sublingual Misoprostol (PGE1) Versus Intracervical Dinoprostone (PGE2) Gel for Induction of Labour: A Randomized Control Trail

Sublingual misoprostol versus intracervical dinoprostone gel for induction of labour: A randomized trial

The Effect of Oral Propranolol plus Oxytocin Versus Oxytocin alone on Induction and Outcome of Labor

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