Comparison of Efficacy and Safety of Topical Dorzolamide-Timolol Maleate Combination with Oral Acetazolamide for Prevention of Intraocular Pressure Rise Following Phacoemulsification Surgery

Abstract

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To compare the efficacy and safety of topical dorzolamide-timolol maleate combination with oral acetazolamide for prevention of intraocular pressure rise following phacoemulsification surgery. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Sixty-seven eyes of 67 patients with cataracts (33 males, 34 females) who had undergone phacoemulsification and intraocular lens implantation surgery were evaluated retrospectively. Patients were divided into two groups. Group 1 comprised 33 (49%) patients who received oral acetazolamide 250 mg (Diazomid 250 mg tb) 1 hour before the surgery and 1hour after surgery and 125 mg 3 times a day for 3 days following surgery. Group 2 comprised 34 (51%) patients who received topical dorzolamidetimolol maleate combination 1 drop 1 hour before the surgery and twice a day for 3 days following surgery. R Re es su ul lt ts s: : The mean preoperative intraocular pressure (IOP) of the first group was 14.60±3.21 standard deviation (SD) (range 10-21) mmHg. and that of the second group was 14.67±2.77 (SD) (11-21) mmHg (p=0.924). The mean postoperative IOP(1 st day) of the first group was 15.27±2.90 (SD) (11-23) mmHg and that of the second group was 14.82±2.57 (SD) (11-23) mmHg (p=0.505). The mean postoperative IOP (1 st week) of the first group was 13.72±2.44 (SD) (10-18) mmHg and that of the second group was 13.64±2.53 (SD) (10-19) mmHg (p=0.895). C Co on nc cl lu us si io on n: : For prophylaxis of postoperative IOP rise after an uneventful cataract surgery, topical-dorzolamid timolol maleate combination and oral acetazolamide therapy have similar effects, however the adverse effects of systemic acetazolamide should be taken into account. Therefore it is better to prefer topical dorzolamide-timolol maleate combination therapy. K Ke ey y W Wo or rd ds s: : Phacoemulsification; intraocular pressure; acetazolamide; dorzolamide-timolol combination Ö ÖZ ZE ET T A Am ma aç ç: : Fakoemülsifikasyon cerrahisi sonrası artan göziçi basıncını azaltmak için kullanılan ağızdan verilen asetazolamid ile damla şeklinde uygulanan dorzolamid-timolol maleat kombinasyonunun etkinlik ve güvenilirliğinin kıyaslanmasıdır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Kataraktı olan ve fakoemülsifikasyon ve göziçi mercek (GİM) implantasyon cerrahisi geçiren 67 (33 erkek, 34 kadın) hastanın 67 gözü retrospektif olarak değerlendirildi. Hastalar iki gruba ayrıldılar. 1. grup 33 (%49) hastadan oluşmaktaydı, bu gruptaki hastalara ameliyattan 1 saat önce ve 1 saat sonra ağızdan 250 mg asetazolamid (toplam 500 mg) verildi ve ameliyattan sonraki 3 gün boyunca da 125 mg asetazolamid 3x1 önerildi. 2. grup 34 (%51) hastadan oluşmaktaydı, bu gruptaki hastalara ameliyattan 1 saat önce 1 damla dorzolamid-timolol maleat kombinasyonu uygulandı ve ameliyattan sonraki 3 gün boyunca da damla şeklinde dorzolamid-timolol maleat kombinasyonu 2x1 şek-linde önerildi. B Bu ul lg gu ul la ar r: : 1. grubun ortalama ameliyat öncesi göziçi basınç değeri 14,60±3,21 (SD)...