Comparison of efficacy and safety of adapalene and benzoyl peroxide-clindamycin combination in the topical treatment of acne vulgaris

A study of effectiveness and safety of topical combination therapy for acne vulgaris patients in dermatology department of a tertiary care teaching hospital

“…27 So, within and in-between group comparison of total lesion count, inflammatory lesion count and noninflammatory lesion count between all three treatment arms revealed almost similar effectiveness to reduce acne lesion counts. Similar results of within and in-between group comparison were seen in study conducted by Dubey et al and Choudhury et al 13,21 As shown in Figure 1, two scale improvement in IGA score is highest in clindamycin plus benzoyl peroxide combination (group A) which was 51.2%. A study conducted by Choudhury et al showed 54.05% of two scale improvement in same treatment group.…”

“…Another study conducted by Dudhia et al showed only one ADR in their study. 13,20 As per Table 7, percentage reduction of DLQI score, in clindamycin-benzoyl peroxide group (group A) from baseline to at the end of treatment in our study was 71.5% followed by clindamycin-adapalene group was 63.7% and benzoyl peroxide-adapalene group was 61.0%. So, within and in-between group comparison of DLQI score between three treatment arms revealed almost similar improvement in quality of life by given topical therapy.…”

“…A study conducted by Ghoshal et al and Dubey et al showed that most of the participants were in the range of 16-20 years and 16-23 years respectively. 12,13 As shown in Table 2, onset of age of acne among female and male participants in present study were 15.57±2.01 years and 16.39±1.70 years respectively. Acne appeared nearly 10 months earlier in females than males related to their androgen activity.…”

“…A study conducted by Dubey et al and by Dudhia et al showed that 67.74% and 53% of participants had grade-II acne respectively. 13,20 Majority of patients (42.3%) were treated with clindamycin and benzoyl peroxide combination therapy named as CLN and BPO group (group A) followed by clindamycin and adapalene combination named as CLN and ADA group (group B) and benzoyl peroxide+ adapalene combination named as BPO and ADA group (group C).…”

“…To check effectiveness of topical combination therapy in our study we had used total lesion count; inflammatory lesion count and non-inflammatory lesion count. Similar methods were used to check effectiveness in a study conducted by Choudhury et al, Dubey et al and Kaur et al 13,21,22 As per Table 3 [24][25][26] Similarly, with the combination of topical 2.5% benzoyl peroxide and 0.1% adapalene (group C) in the percentage reduction of total lesion count 52.8%, inflammatory lesion count 75.6% and non-inflammatory lesion count 43.3% is similar to the study done by Gollnick et al wherein, the percentage reduction in total lesion count was 65.4%, for inflammatory lesion count 70.3% and non-inflammatory lesion count 62.2%. 10 Another study conducted by Thiboutot et al showed percentage reduction in total lesion count was 51.0%, for inflammatory lesion count 62.9% and for non-inflammatory lesion count 51.2%.…”