Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients

Abstract

The study demonstrated that preemptive dexketoprofen trometamol 25 mg is associated with a decrease of up to 35% in morphine consumption compared with placebo over the first 24 h following lumbar disc surgery; however, paracetamol 500 mg did not show the expected opioid-sparing effect comparatively.

Preventive Analgesia with Intravenous Paracetamol for Post-cesarean section Pain Control

“…Acetaminophen inhibits cyclooxygenase activity (COX-3) in central nervous system (CNS). In addition, paracetamol is a weak COX-1 and COX-2 inhibitor (anti-inflammatory effect) (8,13,19). In this study, measurements of blood pressure and heart rate in patients throughout the study period suggest that paracetamol does not have cardiovascular effects.…”

The Effectiveness of Preemptive Analgesic Techniques on Postoperative Analgesia In Patients Undergoing Open Septorhinoplasty

“…Ameliyat sonrası iv HKA ile morfin başlanmış ve deksketoprofen trometamol grubunda tüketilen morfin miktarını anlamlı olarak düşük bulmuşlar, ancak parasetamolün bu açıdan beklenen etkiyi göstermediği kanaatine varmışlar-dır. [21] Çalışmamızda benzer olarak, erken ameliyat sonrası dönemde deksketoprofen trometamol grubunda, asetaminofen ve kontrol grubuna göre daha etkin bir analjezi sağlandığını, tüketilen toplam tramadol miktarının anlamlı düşük olduğunu saptadık.…”

Treatment of Patient Syndrome at the Ambulatory-Polyclinic Stage. Selection of the Analgetic From the Positions of Comorbidity and Drug Safety: In Focus Dexketoprofen

“…Результаты многочисленных зарубежных [32][33][34][35][36][37][38][39][40][41][42][43][44] и отечественных [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] исследований позволяют рассма-тривать НПВП декскетопрофен в числе препаратов воз-можного выбора в группе ненаркотических анальгетиков на амбулаторно-поликлиническом этапе оказания меди-цинской помощи.…”

“…В течение длительного времени декскетопрофен успешно используется не только при стационарном, но и на амбулаторно-поликлиническом этапе лечения паци-ентов, в ортопедии и травматологии [34,37,38,47,48,55,[75][76][77], гинекологии [33,54,[78][79][80][81], общей хирургии [41,42,52,55,82,83], нейрохирургии [39,[84][85][86] и других отраслях медицины [5,56,60].…”