Comparison of efficacy, toxicity and pharmacokinetics of free adriamycin and adriamycin linked to oxidized dextran in rats.

Ueda, Yasuo; Munechika, Koji; Kikukawa, Akihito; Kanoh, Yoshiaki; Yamanouchi, Kouichi; Yokoyama, Kazumasa

doi:10.1248/cpb.37.1639

Cited by 36 publications

(16 citation statements)

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“…One putative approach to modifying anthracyclines is the rational synthesis of antibiotic conjugates with biopolymers, that generally have the ability to prolong the antibiotic action and to decrease its toxicity (3,4). The purpose of the present experimental investigations was to assess the antileukemic effect of original conjugate of anthracycline antitumor antibiotic epirubicin, covalently bound to the chitosan, in comparison with the free epirubicin.…”

Section: Introductionmentioning

confidence: 99%

Antileukemic Effect of Epirubicin Conjugated with Chitosan Against Mouse P388 Ascitic Leukemia

Todorova

Maneva

Ilarionova

et al. 2003

Biotechnology & Biotechnological Equipment

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Section: Introductionmentioning

confidence: 99%

Antileukemic Effect of Epirubicin Conjugated with Chitosan Against Mouse P388 Ascitic Leukemia

Todorova

Maneva

Ilarionova

et al. 2003

Biotechnology & Biotechnological Equipment

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“…A dose of 0.67 mg/kg DOXO equivalent conjugate induced a tumor inhibition growth of about 50%, while the same dose of free DOXO reduced the tumor growth of 20% [110]. A dose of 2 mg/kg of conjugated and free drug inhibited the tumor growth of 81 and 63%, respectively.…”

Section: Doxorubicinmentioning

confidence: 93%

Polysaccharide-Based Anticancer Prodrugs

Caliceti

Salmaso

Bersani

2009

Macromolecular Anticancer Therapeutics

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So far, polysaccharides have been widely used in pharmaceutical technology as first choice excipients for production of traditional formulations. Nevertheless, in the recent years these natural and semisynthetic macromolecules have been addressed for new challenging applications as functional materials for innovative formulations. Their peculiar physicochemical and biological properties have been exploited to develop macromolecular prodrugs which can exhibit favorable biopharmaceutical properties and enforce the therapeutic performance of the parent drugs. These polymers display, in fact, high biocompatibility and biodegradability, multiple insertion points, and biological properties that can be advantageously exploited in drug delivery. In particular, the multifunctional structures of these polymers are anchoring points for conjugation of several anticancer drugs, which usually suffer from poor physicochemical, biopharmaceutical, and therapeutic properties that limit their therapeutic performance and proper use in anticancer treatment. Polysaccharide-based anticancer prodrugs can be designed to endow derivatives with new bioresponse, targeting, or environmental triggering properties or to combine molecules with synergistic therapeutic effect. Over the years, a variety of synthetic protocols have been set up to conjugate anticancer drugs to the polysaccharide backbone via specific linkages or through spacers which convey to the conjugates selective drug-delivery properties. Furthermore, the intrinsic antitumor activity and cell-targeting properties of few polysaccharides represent an additional value to the final therapeutic systems. Anticancer drugs with different pharmacodynamic, pharmacokinetic, and physicochemical properties have been successfully conjugated to various natural and semisynthetic polysaccharides highlighting the interesting perspectives for exploitation of new promising anticancer polymer therapeutics.

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“…The synthesis of antibiotic conjugates with biopolymers is a relatively new trend of research which generally has the purpose of prolongating the antibiotic action and decreasing of its toxicity (2,3). The antitumor effect of 5-fluoro uracil bound to chitosan is also studied (4).…”

Section: Introductionmentioning

confidence: 99%

Studies on the Synthesis of Antibiotic Conjugates with Chitosan

Krysteva

Todorova

Maneva

et al. 1997

Biotechnology & Biotechnological Equipment

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Chitosan is stepwise treated with periodic acid, urea and formaldehyde and then introduced hydroxymethyl groups reacted with tetracycline and carminomycin. The conjugates obtained are fully soluble in dirnethylforrnamide in contrast to the ji·ee chitosan. The conjugate of chitosan with tetracycline preserves almost ful(v the antibacterial activity of the free tetrac_vc-line. An enhenced antitumour activity and decreased toxicity of carminomycin are detected after its conjugation with chitosan.

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Comparison of efficacy, toxicity and pharmacokinetics of free adriamycin and adriamycin linked to oxidized dextran in rats.

Cited by 36 publications

References 0 publications

Antileukemic Effect of Epirubicin Conjugated with Chitosan Against Mouse P388 Ascitic Leukemia

Antileukemic Effect of Epirubicin Conjugated with Chitosan Against Mouse P388 Ascitic Leukemia

Polysaccharide-Based Anticancer Prodrugs

Studies on the Synthesis of Antibiotic Conjugates with Chitosan

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