Comparison of electrophysiological and radiological subthalamic nucleus length and volume

Abstract

AIM:To investigate the surgical value of MER recordings and improve surgical technique by demonstrating the consistency between preoperative radiological STN volume and intraoperative neurophysiological STN length. MATERIAL and METHODS:Sixty-one patients with PD were enrolled. The volumes of the STN were measured using magnetic resonance images 3-dimensional volume reconstructions of stereotactic magnetic resonance images. MER were performed in all patient and the maximal electrophysiologic length of the STN was recorded each patient. In the postoperative period, the permanent electrode was modeled and reconstructed in 3D, and the longest distance traveled in the STN was calculated. RESULTS:A total of 61 patients who underwent surgery between 2012-2022 were included in the study. Thirty-six (59%) of the patients were male, and 25 (41%) were female. A total of 122 STNs were performed with 166 electrodes. The most common end alignment used was center with 86. STN length averaged 4.9 mm (0-10.5 mm). The mean STN volume was 0.11 cm 3 . The STN Volume of men were significantly higher than women. The STN Length, Volume, and the target MER length showed a positive correlation significantly. CONCLUSION:With radiological advances, it is possible to better visualize the target points and define the boundaries better, and direct methods can be used more in making targeting plans. MER records obtained during surgery and STN dimensions in presurgical planning show compatibility, and it is seen that there may be differences between the right and left sides because of brain shifting. Although radiology is increasingly providing better support, electrophysiological recordings provides real-time information on the electrodes' locations and give the opportunity to surgical team choosing alternative target.

Utility of diffusion tensor imaging and generalized q-sampling imaging for predicting short-term clinical effect of deep brain stimulation in Parkinson’s disease

“…Firstly, both the subthalamic nucleus (STN), a crucial target in DBS, and subsequently, other brain regions including the thalamus, globus pallidus externus (Gpe), globus pallidus internus (Gpi), and substantia nigra (SN), which have been reported to be affected in PD, were volumetrically segmented [ 35 ]. All segmentations were conducted automatically, which is a notable strength of this study, using the atlas of ICBM-152 space [ 42 ].…”

Türkiye'deki Öğrencilerin Nöroşirürji ve Diğer Uzmanlık Kariyer Tercihlerinin Karşılaştırılması

“…Neurosurgery is one of the most developing departments thanks to recent technological improvements (4). Today, neurosurgeons perform endoscopic, endovascular, radiosurgery and stereotactic minimally invasive procedures besides microsurgery (5)(6)(7)(8).…”