Comparison of Electrospun and Extruded Soluplus®-Based Solid Dosage Forms of Improved Dissolution

AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

“…In the case of the physical mixture of HPMC+5%SPIR, the most intense peaks of SPIR were still observable and a weak sign of organized structure of HPMC also emerged at 2Θ=32° which latter was confirmed by earlier studies as well (Verreck et al, 2003b). Bearing in mind all these and considering that SPIR is a poor glass former meaning that it rather tends to crystallize or remain crystalline than form amorphous clusters (Nagy et al, 2012), the absence of any X-ray diffraction phenomenon or endothermic melting peaks signifies a mixed amorphous form of all components including SPIR in the HPMC-based solid dispersions.…”

“…However, as an interesting side effect the reduction in average fiber diameter could be observed during ACES along with increasing SPIR loading. Our former experience with DC electrospun SPIR-loaded fibers showed that addition of the drug at relatively low ratio (≤20%) led to detectable thickening compared to the placebo nonionic Soluplus® fibers (Nagy et al, 2012). In order to explore the observed diameter reducing effect of ACES, the SPIR-loaded optimized HPMC-PEO fibers were also prepared with DCES applying a necessarily lower feeding rate (10 mL/h) and the same voltage as during ACES (25 kV DC).…”

“…Among other physical approaches such as nanosuspensions (Müller et al, 2001), crystallization techniques (Fages et al, 2004;Rasenack and Müller, 2002) and the use of solubilizers (e.g., surfactants (Lawrence and Rees, 2000;Pouton, 1997) and cyclodextrins (Brewster and Loftsson, 2007)), polymerbased solid dispersions has received a great deal of attention to overcome the hurdle of limited solubility (Vasconcelos et al, 2007). Amorphous solid dispersion of a drug in an inert water-soluble matrix (most often a polymer) ensure improved dissolution owing to three reasons: on the one hand higher solubility of the amorphous drug, on the other hand the wellsoluble hydrophilic carrier used, thirdly an increased surface area can be obtained depending on the preparation method (Nagy et al, 2012). Accordingly, several amorphous solid dispersion-based products have been reached commercialization in the pharmaceutical market (Vaka et al, 2014).…”

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

“…especially favourable in the field of pharmaceutical application [7][8][9][10][11][12][13][14][15][16][17][18]. Although the electrospinning (ES) is fast developing with appearance of tri-axial, coaxial, side-by-side and their combination processes [19][20][21][22] the most common and facile ES equipment is the single needle apparatus [23,24].…”

The effect of needleless electrospun nanofibrous interleaves on mechanical properties of carbon fabrics/epoxy laminates

“…Most of these studies address the possibility of using such nanofibers in filtering, biomedical, sensor and clothing applications [1][2][3][4]. Because of their high surface-area-to-volume ratio, the nanofibrous materials could also be efficient reinforcing materials in polymer matrix composites.…”