Comparison of endocrine and ultrasound profiles during ovulation induction with clomiphene citrate and letrozole in ovulatory volunteer women

Jirge, Padma Rekha; Patil, R. S.

doi:10.1016/j.fertnstert.2008.10.009

Cited by 30 publications

(16 citation statements)

References 26 publications

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“…Several medications and regimens have been used for induction of ovulation in PCOS, but none has had a significant outcome. Examples of such treatments include clomiphene, letrozole, metformin, gonadotropins, gonadotrophin-releasing hormone agonists, cauterization and wedge resection of the ovaries, and assisted reproductive technology 3,7,8…”

Section: Discussionmentioning

confidence: 99%

“…Multiple treatments have been recommended for infertility in patients with PCOS, including weight reduction, clomiphene citrate, metformin, gonadotropins, pulsed gonadotropin-releasing hormone, gonadotropin-releasing hormone agonists, ovary cauterization, ovarian wedge resection, letrozole, and assisted reproductive technology, such as in vitro fertilization 3,7,8…”

Section: Introductionmentioning

confidence: 99%

“…Letrozole, as opposed to clomiphene, is rapidly excreted,17 and causes ovulation in 60%–80% of patients;18 in clomiphene-resistant patients, it caused ovulation in 62% of cases, and pregnancy occurred in 14.7% of patients. Letrozole does not have any adverse effects on the fetus and is safe 7,8,18. Letrozole decreases the secretion of estrogen both in the brain and in the periphery, and causes an increase in gonadotropins, which in turn causes maturation of the ovarian follicles.…”

Section: Introductionmentioning

confidence: 99%

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Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome

Hajishafiha¹,

Dehghan²,

Kiarang³

et al. 2013

DDDT

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BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age (6.8%–18%), is among the most common causes of infertility due to ovulation factors, and accounts for 55%–70% of infertility cases caused by chronic anovulation. In this study, we used a combination of letrozole and clomiphene in patients resistant to both drugs individually, and studied the effects of this combination in ovulation and pregnancy in resistant PCOS patients.MethodsThe study population included infertile couples diagnosed as PCOS in the wife. The women used clomiphene for at least six cycles in order to ovulate after failure to form the dominant follicle, and were then put on letrozole for four cycles. Patients who were unable to form the dominant follicle were enrolled on letrozole and clomiphene combination therapy.ResultsOne hundred enrolled patients underwent 257 cycles of a combination of letrozole and clomiphene, in which 213 were able to form the dominant follicle (82.9%) and 44 were unable to do so (17.1%). The number of mature follicles was 2.3±1.1. The mean endometrial thickness in patients on the day of human chorionic gonadotropin administration was 8.17±1.3 mm. The pregnancy rate was 42%.ConclusionAccording to the results of this study, it can be proposed that in PCOS patients resistant to clomiphene and letrozole used as single agents, a combination of the two drugs can be administered before using more aggressive treatment that may have severe complications or surgery. This combination may also be used as a first-line therapy to induce ovulation in severe cases of PCOS in order to save time and expense.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome

Hajishafiha¹,

Dehghan²,

Kiarang³

et al. 2013

DDDT

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“…With permission from Elsevier) discrepancy between the ovulation rate (85 %) and the pregnancy rate (43 %) of women receiving CC treatment. Jirge and Patil [ 30 ] have demonstrated in a prospective crossover study that the number of follicles at the assumed time of ovulation is signifi cantly higher in patients treated with clomiphene citrate; moreover, the endometrial thickness on the same day was signifi cantly smaller (7.6 mm vs. 8.5 mm). Most investigators report decreased secretion of mucus from the cervical glands caused by antiestrogenic agents such as CC.…”

Section: Antiestrogenic Effects On the Cervix And Endometriummentioning

confidence: 99%

Ultrasound in Follicle Monitoring for Ovulation Induction/IUI

Blankstein

Malepati

Brasch

2013

Ultrasound Imaging in Reproductive Medicine

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“…demonstrates between one and two mature follicles grown at this dose. [1,16,17,18] Conversely, couples being treated for male factor or unexplained infertility with many unsuccessful cycles might wish for maturation of three or four follicles. [19] Various studies reveal a dose-response with letrozole, with higher doses producing more mature follicles and higher ovulation rates.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Glimpse on Splendid Aromatase Inhibitor – Letrozole - A Pragmatic Review

Neerjesh¹

2017

WJPR

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Letrozole is the third-generation aromatase inhibitor (AI) most commonly used in assisted reproduction. It brings ovulation by inhibiting estrogen production; the consequent hypoestrogenic state enhances GnRH release and pituitary follicle-stimulating hormone (FSH) synthesis. Letrozole has fewer side effects, and a shorter halflife than clomiphene citrate, and no demonstrable effect upon the receptivity of the endometrium. It is effective in treating women with chronic anovulation, unexplained infertility and diminished ovarian reserve. Its safety is superior to clomiphene citrate. Utilizing bioequivalent doses, letrozole pregnancy rates are equal or superior to clomiphene citrate. Several studies reveal situations where it is more efficacious than gonadotropin treatment. A conclusion established was letrozole is as effective as other methods of ovulation induction. Further randomizedcontrolled studies are warranted to define more clearly the efficacy and safety of letrozole in human reproduction.

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Comparison of endocrine and ultrasound profiles during ovulation induction with clomiphene citrate and letrozole in ovulatory volunteer women

Cited by 30 publications

References 26 publications

Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome

Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome

Ultrasound in Follicle Monitoring for Ovulation Induction/IUI

Glimpse on Splendid Aromatase Inhibitor – Letrozole - A Pragmatic Review

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