Comparison of Endometrial Biopsy Results of Premenopausal and Postmenopausal Patients

Abstract

Objective: To evaluate the histopathological results of endometrial biopsy specimens obtained from patients who referred to our clinic with a complaint of abnormal uterine bleeding (AUB) and to compare the results of premenopausal and postmenopausal patients. Methods: In this retrospective study, the records of patients who referred to our clinic due to AUB between 2013 and 2017, and who had undergone endometrial biopsy with pipelle were evaluated. Demographic data and menopausal status of the patients were recorded. Endometrial biopsy results of all patients were investigated. In addition, the patients were divided into two groups as premenopausal and postmenopausal. Endometrial biopsy results of both groups were compared. Results: While 2808 (56.1%) of the 5000 patients who referred with AUB and who had undergone endometrial sampling were premenopausal, 2192 (43.8%) were postmenopausal. The mean age of the premenopausal and postmenopausal groups was found to be 41.6 ± 1.8 and 54.2 ± 5.9, respectively. Secretory endometrium was significantly higher in the premenopausal group than the postmenopausal group (p <0.001). While atrophic endometrium and malignancy were significantly higher in the postmenopausal group than the premenopausal group, chronic endometritis was significantly higher in the premenopausal group. Conclusion: Endometrial biopsy, which is a simple, inexpensive and easy technique, is the most preferred method for the exclusion of malignancy in patients with complaint of AUB. In patients with complaint of AUB, malignancy exclusion decision by endometrial biopsy must be made considering the age interval, risk factors that may cause estrogen exposure, and menopausal status of the patients.