Comparison of endometrial prostanoid profiles in three infertile subgroups: the missing part of receptivity?

Keleş, Irem Demiral; Ülgen, Ege; Erkan, Melike; Çelik, Saliha Esin; Aydın, Yasemin; Önem, Ayşe Nur; Kandemir, Hülya; Arslanoğlu, Tuğçe; Apak, Mustafa; Sezerman, Uğur; Yeh, John; Buyru, Faruk; Baştu, Ercan

doi:10.1016/j.fertnstert.2019.10.017

Cited by 7 publications

(3 citation statements)

References 63 publications

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“…Furthermore, platelet and endothelial cell adhesion molecule 1 (PECAM1) and transforming growth factor β1 (TGF-β1) were also significantly reduced in RIF (Guo et al, 2018). Apart from altered implantation markers, it has been previously shown that prostaglandins' synthesis is deranged in case of RIF, implying a defective endometrial inflammation in favor of implantation failure (Achache et al, 2010;Demiral Keleş et al, 2020). Finally studies evaluating metabolomics (RoyChoudhury et al, 2016) and microRNAs (Shi et al, 2017) have shown that RIF may be featured by a significant different profile that could be associated with poor reproductive outcome.…”

Section: Non-immunological Disordersmentioning

confidence: 99%

Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures

Makrigiannakis

Makrygiannakis

Vrekoussis

2021

Front. Cell Dev. Biol.

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Repeated implantation failures are a constant challenge in reproductive medicine with a significant impact both on health providers and on infertile couples. Several approaches have been proposed so far as effective; however, accumulative data have clarified that most of the treatment options do not have the evidence base for a generalized application to be suggested by the relevant societies. Implantation failures are attributed to either poor quality embryos or to defected endometrial receptivity. The current review aims to summarize in a systematic way all the new trends in managing RIF via interference with endometrial receptivity. The authors focus mainly, but not exclusively, on endometrial injury prior to embryo transfer and endometrial priming with autologous cells or biological agents. To this direction, a systematic search of the Pubmed database has been conducted taking into account the emerged evidence of the last two decades. All the suggested interventions are herein presented and analyzed in terms of reproductive outcomes. It is evident that properly powered and designed randomized trials are needed to support a new standard approach in RIF treatment that will safely be incorporated in national and international guidelines.

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Section: Non-immunological Disordersmentioning

confidence: 99%

Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures

Makrigiannakis

Makrygiannakis

Vrekoussis

2021

Front. Cell Dev. Biol.

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“…Arachidonic acid-derived prostaglandins have also been shown to play a regulatory role in embryo implantation and uterine receptivity via angiogenesis stimulation and myometrium relaxation and contraction [ 29 ]. PGE 2 and PGF 2α can be involved in maternal–embryonal crosstalk and successful implantation in both animal [ 34 , 35 , 36 , 37 ] and human studies [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid Changes in the Peri-Implantation Period with Mass Spectrometry Imaging: A Systematic Review

Gitta

Márk

Szentpéteri

et al. 2023

Life

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Mass spectrometry imaging is a sensitive method for detecting molecules in tissues in their native form. Lipids mainly act as energy stores and membrane constituents, but they also play a role in lipid signaling. Previous studies have suggested an important role of lipids in implantation; therefore, our aim was to investigate the lipid changes during this period based on the available literature. The systematic literature search was performed on Ovid MEDLINE, Cochrane Library, Embase, and LILACS. We included studies about lipid changes in the early embryonal stage of healthy mammalian development published as mass spectrometry imaging. The search retrieved 917 articles without duplicates, and five articles were included in the narrative synthesis of the results. Two articles found a different spatial distribution of lipids in the early bovine embryo and receptive uterus. Three articles investigated lipids in mice in the peri-implantation period and found a different spatial distribution of several glycerophospholipids in both embryonic and maternal tissues. Although only five studies from three different research groups were included in this systematic review, it is clear that the spatial distribution of lipids is diverse in different tissues and their distribution varies from day to day. This may be a key factor in successful implantation, but further studies are needed to elucidate the exact mechanism.

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“…AA is, in turn, metabolized by cyclooxygenases (COXs), lipoxygenases (LOXs) and nitric oxide synthase (NO S ), giving rise to different oxidation products such as PGs, thromboxanes (TXs), leukotrienes (LTs) and lipoxins (LXs). Cytokines trigger the up-regulation of COX-2 expression; as result, the COX-2-dependent prostaglandin E2 (PGE 2 ) biosynthesis is higher in the peritoneal fluid of EMS patients compared to normal endometrium [ 16 , 18 , 19 , 20 , 21 ]. This inflamed micro-environment strongly sustains the proliferation and invasion of the endometrium epithelial and stromal cells, reducing apoptosis and enhancing angiogenesis [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Endometriosis Treatment: Role of Natural Polyphenols as Anti-Inflammatory Agents

et al. 2023

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Endometriosis is an estrogen-dependent common chronic inflammatory disease defined by the presence of extrauterine endometrial tissue that promotes pelvic pain and fertility impairment. Its etiology is complex and multifactorial, and several not completely understood theories have been proposed to describe its pathogenesis. Indeed, this disease affects women’s quality of life and their reproductive system. Conventional therapies for endometriosis treatment primarily focus on surgical resection, lowering systemic levels of estrogen, and treatment with non-steroidal anti-inflammatory drugs to counteract the inflammatory response. However, although these strategies have shown to be effective, they also show considerable side effects. Therefore, there is a growing interest in the use of herbal medicine for the treatment of endometriosis; however, to date, only very limited literature is present on this topic. Polyphenols display important anti-endometriotic properties; in particular, they are potent phytoestrogens that in parallel modulates estrogen activity and exerts anti-inflammatory activity. The aim of this review is to provide an overview on anti-inflammatory activity of polyphenols in the treatment of endometriosis.

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Comparison of endometrial prostanoid profiles in three infertile subgroups: the missing part of receptivity?

Cited by 7 publications

References 63 publications

Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures

Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures

Lipid Changes in the Peri-Implantation Period with Mass Spectrometry Imaging: A Systematic Review

Endometriosis Treatment: Role of Natural Polyphenols as Anti-Inflammatory Agents

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