Comparison of endoscopic therapies for rectal neuroendocrine tumors: endoscopic submucosal dissection with myectomy versus endoscopic submucosal dissection

Sun, Ping; Zheng, Tuo; Hu, Chunjiu; Gao, Tengjiao; Ding, Xiaoyun

doi:10.1007/s00464-021-08622-8

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…A study on rectal NETs < 16 mm without metastasis demonstrated that endoscopic submucosal dissection with myectomy yielded a higher rate of histological complete resection 2 . Additionally, reports have shown the feasibility and safety of EID for T1 rectal cancer 3 4 .…”

Section: Figmentioning

confidence: 99%

Endoscopic intermuscular dissection in the management of a rectal neuroendocrine tumor

Liao,

Li,

Huang

et al. 2023

Endoscopy

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Section: Figmentioning

confidence: 99%

Endoscopic intermuscular dissection in the management of a rectal neuroendocrine tumor

Liao,

Li,

Huang

et al. 2023

Endoscopy

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“…There are several different endoscopic resection options. These include standard snare polypectomy, endoscopic mucosal resection (EMR), EMR-band ligation, EMR-cap fitted, EMR-underwater, EMR-ligation (EMR-L), endoscopic submucosal dissection (ESD) and ESD muscle ligation (ML) [17,[19][20][21].…”

Section: Endoscopic Therapymentioning

confidence: 99%

Optimising Outcomes and Surveillance Strategies of Rectal Neuroendocrine Neoplasms

Srirajaskanthan

Clement

Brown

et al. 2023

Cancers

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Rectal neuroendocrine neoplasms are increasing in incidence, in part due to increased endoscopic procedures being performed for bowel cancer screening. Whilst most of these lesions are low-grade well-differentiated neuroendocrine tumours, they can have a varied clinical behaviour. Frequently, these lesions are incorrectly characterised at endoscopy and, therefore, incompletely excised using standard polypectomy techniques. Furthermore, some cases are not fully staged prior to or post resection. In this article we discuss the endoscopic and surgical options available to improve the likelihood of achieving an R0 resection and the staging procedures that should be used in these NETs. We also review factors that may suggest a higher risk of nodal involvement or recurrence. This information may help determine whether endoscopic or surgical resection techniques should be considered. In cases of R1 resection we discuss the management options available and the long-term surveillance options and when these should be offered to patients.

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“…Endoscopic submucosal dissection with myectomy for rectal NETs may overcome the risk of vertical margin invasion. Comparison of this new method with ESD alone has proven its safety and effectiveness for nonmetastatic lesions less than 16 mm[ 58 ].…”

Section: Diagnosismentioning

confidence: 99%

Molecular factors, diagnosis and management of gastrointestinal tract neuroendocrine tumors: An update

Pavlidis¹,

Pavlidis²

2022

WJCC

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The prevalence of gastrointestinal neuroendocrine tumors (GI-NETs) is increasing, and despite recent advances in their therapy, it remains inadequate in patients with advanced well-differentiated neuroendocrine tumors. These tumors present many challenges concerning the molecular basis and genomic profile, pathophysiology, clinicopathological features, histopathologic classification, diagnosis and treatment. There has been an ongoing debate on diagnostic criteria and clinical behavior, and various changes have been made over the last few years. Neuroendocrine carcinoma of the gastrointestinal system is a rare but highly malignant neoplasm that is genetically distinct from gastrointestinal system neuroendocrine tumors (NETs). The diagnosis and management have changed over the past decade. Emerging novel biomarkers and metabolic players in cancer cells are useful and promising new diagnostic tools. Progress in positron emission tomography-computerized tomography and scintigraphy with new radioactive agents ( 64 Cu-DOTATATE or 68 Ga-DOTATATE) replacing enough octreoscan, has improved further the current diagnostic imaging. Promising results provide targeted therapies with biological agents, new drugs, chemotherapy and immunotherapy. However, the role of surgery is important, since it is the cornerstone of management. Simultaneous resection of small bowel NETs with synchronous liver metastases is a surgical challenge. Endoscopy offers novel options not only for diagnosis but also for interventional management. The therapeutic option should be individualized based on current multidisciplinary information.

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Comparison of endoscopic therapies for rectal neuroendocrine tumors: endoscopic submucosal dissection with myectomy versus endoscopic submucosal dissection

Cited by 9 publications

References 21 publications

Endoscopic intermuscular dissection in the management of a rectal neuroendocrine tumor

Endoscopic intermuscular dissection in the management of a rectal neuroendocrine tumor

Optimising Outcomes and Surveillance Strategies of Rectal Neuroendocrine Neoplasms

Molecular factors, diagnosis and management of gastrointestinal tract neuroendocrine tumors: An update

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