Comparison of endoscopic ultrasonography (EUS), positron emission tomography (PET), and computed tomography (CT) in the preoperative locoregional staging of resectable esophageal cancer

Choi, Jeongmin; Kim, Sang Gyun; Kim, Sang Woo; Jung, Hyun Chae; Song, In Sung

doi:10.1007/s00464-009-0783-x

Cited by 143 publications

(101 citation statements)

References 23 publications

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“…These imaging modalities have remarkably similar performance in cN assessment: accuracy is reported to be 66% for EUS, 63% for CT, and 68% for PET, sensitivities 42%, 35%, and 35%, respectively, and specificities 91%, 93%, and 87%, respectively (33).…”

Section: Histologic Cell Typementioning

confidence: 98%

8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice

Rice¹,

Patil²,

Blackstone³

2017

Ann. Cardiothorac. Surg.

601

373

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Section: Histologic Cell Typementioning

confidence: 98%

8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice

Rice¹,

Patil²,

Blackstone³

2017

Ann. Cardiothorac. Surg.

601

373

View full text Add to dashboard Cite

“…EUS performed before any treatment provides evidence of depth of tumor invasion (T), presence of abnormal or enlarged lymph nodes likely to harbor cancer (N), and occasionally signs of distant spread, such as lesions in surrounding organs (M). 100,101 Mediastinal and perigastric lymph nodes are readily identified with EUS, and identification of enlarged, hypoechoic (dark), homogeneous, well-circumscribed, rounded structures in these areas indicates the presence of malignant or inflammatory lymph nodes. The accuracy of this diagnosis is significantly increased with the combination of features, but is also confirmed with FNA biopsy for cytology assessment.…”

Section: Principles Of Endoscopymentioning

confidence: 99%

Esophageal and Esophagogastric Junction Cancers

Ajani¹,

Barthel²,

Bentrem³

et al. 2011

J Natl Compr Canc Netw

213

153

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“…CT is used most widely in the staging of esophageal cancer, it can show the size, number and anatomical location of the enlarged lymph nodes clearly, and determine the staging of lymph node combined with morphological changes. However, their effect is not very satisfactory, because enlarged lymph nodes may not be caused by cancer metastasis, and tumors could be existed in normal-sized lymph nodes (Choi et al, 2010). Additionally, enhanced scan is usually needed to distinguish metastatic lymph nodes and normal structures, but patients allergic to iodine can not perform this examination.…”

Section: Combination Of Fdg Pet/ct and Contrast-enhanced Msct In Detementioning

confidence: 99%

Combination of FDG PET/CT and Contrast-Enhanced MSCT in Detecting Lymph Node Metastasis of Esophageal Cancer

Tan

Yao²,

Huang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (18), 7719-7724 IntroductionEsophageal cancer is the ninth malignant tumor in death in the world. There is an average of 150, 000 people died of esophageal cancer every year and ranked forth in China. The 5-year survival rate is less than 10% for patients suffering from esophageal cancer, and showed poor prognosis. The reason may be due to that the majority of patients have been diagnosed as advanced when perceived, and full-thickness esophageal wall has been involved or lymph node metastasis and distant metastasis has occurred. Lymph node metastasis and metastatic numbers are believed as dependent negative AbstractBackground: Lymph node metastasis is believed to be a dependent negative prognostic factor of esophageal cancer. To explore detection methods with high sensitivity and accuracy for metastases to regional and distant lymph nodes in the clinic is of great significance. This study focused on clinical application of FDG PET/CT and contrast-enhanced multiple-slice helical computed tomography (MSCT) in lymph node staging of esophageal cancer. Materials and Methods: One hundred and fifteen cases were examined with enhanced 64-slice-MSCT scan, and FDG PET/CT imaging was conducted for neck, chest and upper abdomen within one week. The primary lesion, location and numbers of metastatic lymph nodes were observed. Surgery was performed within one week after FDG PET/CT detection. All resected lesions were confirmed histopathologically as the gold standard. Comparative analysis of the sensitivity, specificity, and accuracy based on FDG PET/CT and MSCT was conducted. Results: There were 946 lymph node groups resected during surgery from 115 patients, and 221 were confirmed to have metastasis pathologically. The sensitivity, specificity, accuracy of FDG PET/CT in detecting lymph node metastasis were 74.7%, 97.2% and 92.0%, while with MSCT they were 64.7%, 96.4%, and 89.0%, respectively. A significance difference was observed in sensitivity (p=0.030), but not the others (p>0.05). The accuracy of FDG PET/CT in detecting regional lymph node with or without metastasis were 91.9%, as compared to 89.4% for MSCT, while FDG PET/CT and MSCT values for detecting distant lymph node with or without metastasis were 94.4% and 94.7%. No significant difference was observed for either regional or distant lymph node metastasis. Additionally, for detecting para-esophageal lymph nodes metastasis, the sensitivity of FDG PET/CT was 72%, compared with 54.7% for MSCT (p=0.029). Conclusions: FDG PET/CT is more sensitive than MSCT in detecting lymph node metastasis, especially for para-esophageal lymph nodes in esophageal cancer cases, although no significant difference was observed between FDG PET/CT and MSCT in detecting both regional and distant lymph node metastasis. However, enhanced MSCT was found to be of great value in distinguishing false negative metastatic lymph nodes from FDG PET/CT. The combination of FDG PET/CT with MSCT should improve the accuracy in lymph node metastasis staging of esophageal cancer.

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Comparison of endoscopic ultrasonography (EUS), positron emission tomography (PET), and computed tomography (CT) in the preoperative locoregional staging of resectable esophageal cancer

Abstract: Preoperative EUS for the locoregional staging of esophageal cancer provides excellent T staging accuracy and similar accuracy for N staging compared with PET and CT. Especially in T staging, EUS could play an important role in the choice of candidates for esophageal cancer surgery.

Cited by 143 publications

References 23 publications

8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice

8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice

Esophageal and Esophagogastric Junction Cancers

Combination of FDG PET/CT and Contrast-Enhanced MSCT in Detecting Lymph Node Metastasis of Esophageal Cancer

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