Comparison of enzyme-cytochemical findings and immunological marker investigations in acute lymphatic leukemia (ALL)

Andreewa, P.; Huhn, D.; Thiel, Eckhard; Rodt, H.

doi:10.1007/bf01880680

Cited by 13 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In acute lymphoblastic leukaemia (ALL) especially AP is pronounced in T-ALL [Ritter et al, 1975;Catovsky, 1975;Winkler et al, 1977;Greaves, 1978;Andreewa et al, 1978], ANAE has also been demonstrated in T-ALL [Kulenkampf et al, 1977;Basso et al, 1980a]. In normal peripheral blood T cells, a specific stain ing pattern of ANAE in Tm cells has been claimed (1-2 large dots) [Gross/ et al, 1978;Manconi et al, 1979].…”

Section: Introductionmentioning

confidence: 99%

Immunological Phenotype Related to Acid Alpha-Naphthyl Acetate Esterase and Acid Phosphatase in Childhood Acute Lymphoblastic Leukaemia

Huismans¹,

Zantwijk²

1983

Acta Haematol

View full text Add to dashboard Cite

In 83 children with acute lymphoblastic leukaemia (ALL) the immunological phenotype of the lymphoblasts was determined using E rosetting, monoclonal anti-T cell sera, surface immunoglobulin staining and common ALL antiserum. The data were compared with acid alpha-naphthyl acetate esterase (ANAE) and acid phosphatase (AP) cytochemical data. The vast majority of T-ALL cells proved to be ANAE-negative (30/31) and AP-positive (29/31). Null-ALL was always AP-negative (12/12), the ANAE reaction was sometimes positive (4/12). In common ALL, findings ranged from negative to positive for both enzymes. Two cases of B-ALL were ANAE-negative and AP-negative. Enzyme cytochemical determinations gave thus preferential patterns, especially for T-ALL and null-ALL. In common ALL, considerable heterogeneity was found, which may be a reflection of differences in maturation between different cases of common ALL.

show abstract

Section: Introductionmentioning

confidence: 99%

Immunological Phenotype Related to Acid Alpha-Naphthyl Acetate Esterase and Acid Phosphatase in Childhood Acute Lymphoblastic Leukaemia

Huismans¹,

Zantwijk²

1983

Acta Haematol

View full text Add to dashboard Cite

show abstract

“…In ALL, the circumscript~ "dot-like" reaction of both APh and ANAE is seen prevalently in T-subtypes [1,3]; a detailed comparison of the results of membrane marker investigations and cytochemistry in 100 cases of ALL will be published elsewhere. In B-CLL, malignant lymphatic cells may be differentiated from normal T-lymphocytes by ANAE-staining.…”

Section: Discussionmentioning

confidence: 98%

“…For this purpose, acid-phosphatase-cytochemistry [1,3] and nonspecific esterase activity [17,19] were investigated. Acid phosphatase (APh) proved useful to recognize certain subtypes of T-cell-type acute lymphatic leukemia (T-ALL) [3].…”

Section: Phocytes -Malignant Lymphoma -Lymphatic Leukemiamentioning

confidence: 99%

Classification of normal and malignant lymphatic cells using acid phosphatase and acid esterase

1980

Self Cite

View full text Add to dashboard Cite

normal lymphocytes subfractionated by rosetting and centrifugation, and in M. Hodgkin and CLL; lymphoblastoid cell lines; malignant lymphatic cells in different types of lymphatic leukemia. In normal human blood, T-lymphocytes are marked by a distinct "dot-like" ANAE-reactivity which is somewhat less pronounced in the small (11%) subgroup of Fc-IgG-receptor positive T-lymphocytes; B-lymphocytes are negative or finely granular positive. Lymphoblastoid cell lines of B- and of T-type are ANAE- and APh-positive. In some lymphatic malignancies, a characteristic pattern of activity of APh or of ANAE may support the diagnosis. The value of ANAE-cytochemistry is highly estimated for the quantitative determination of the percentage of normal T-lymphocytes lymphatic leukemias, immunological disorders, and during immunosuppressive therapy.

show abstract

“…An den Tupf-und Ausstrichpräparaten waren zur CharakterisieruJII der lb L und zum gleichzeitigen Ausschluß unreifer myeloischer und myelomonozytärer Neoplasien follende zytochemische Reaktionen ausgefllhrt worden (methodische übersicht bei , und Schwarze, 1980 Brouet et al, 1976;Stein et al, 1976;Chessels et al, 1977;Andreewa et al, 1978;Williams et al, 1978;Boucheix et al, 1980). In einem unserer T-lb L konnte zytochemisch die DAP IV nachgewiesen werden.…”

Section: Zusammenfassungunclassified

Die lymphoblastischen Lymphome des Kindesalters*

Schwarze¹,

Pileri²,

Tolksdorf³

et al. 1981

Klin Padiatr

View full text Add to dashboard Cite

Sections of lymph node and tumor biopsies from 60 patients (51 children, 9 adults) with lymphoblastic lymphoma (lbL) were examined in a bind trial to determine whether the subtype of lbL can be diagnosed on the basis of morphologic criteria alone The diagnoses made in this trial were correct in 18 of 20 cases (adults and children) that had been classified as T-, B-, or non-T/non-B-lbL by immunologic, cytochemical (DAP IV, or virologic (EBV) analysis. In 48 of the 51 children, the subclassification made in the blind trial agreed with the definitive diagnosis. In addition to the results of the blind trial, the morphologic characteristics of T- and B-lbL are presented and the diagnostic value of cytochemical staining for acid phosphates is discussed.

show abstract

Comparison of enzyme-cytochemical findings and immunological marker investigations in acute lymphatic leukemia (ALL)

Cited by 13 publications

References 17 publications

Immunological Phenotype Related to Acid Alpha-Naphthyl Acetate Esterase and Acid Phosphatase in Childhood Acute Lymphoblastic Leukaemia

Immunological Phenotype Related to Acid Alpha-Naphthyl Acetate Esterase and Acid Phosphatase in Childhood Acute Lymphoblastic Leukaemia

Classification of normal and malignant lymphatic cells using acid phosphatase and acid esterase

Die lymphoblastischen Lymphome des Kindesalters*

Contact Info

Product

Resources

About