Comparison of Epidermal Morphologic Response to Commercial Antiwrinkle Agents in the Hairless Mouse

Bhattacharyya, Tapan K.; Higgins, Natalie P.; Sebastian, J Scott; Thomas, J. Regan

doi:10.1111/j.1524-4725.2009.01196.x

Cited by 15 publications

(13 citation statements)

References 45 publications

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“…Subcutaneous pellets of estrogen in ovariectomized photoaged mice protect dermal hyaluronan/versican matrix by the release of epidermal growth factor from keratinocytes, 26 which supports the observation of epidermal stimulation by topical estrogen application in the nonirradiated HM skin as previously reported. 27 In the present study with estrogen, an increase in dermal cellularity and a predominant effect on fibroblast multiplication were the only effects noted. An effect of estrogen on fibroblast proliferative response in the cardiac tissue has been reported, and this was due to the activation of mitogen-activated protein kinase-dependent pathways.…”

Section: Discussionsupporting

confidence: 43%

Dermal Histology in Mouse Skin Exposed to Cosmeceuticals

et al. 2017

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Chronic exposure to environmental ultraviolet radiation elicits deleterious photoaging changes and histopathological damage to the skin. In addition to cosmetic surgical procedures, over-the-counter products described as cosmeceuticals are widely used by a large segment of globally aging populations to partially reverse changes induced by photoaging. Many such products are rarely examined in the laboratory to examine their ameliorative properties and microscopic effects on various skin compartments. The hairless mouse is a popular animal model widely used over the last few decades by researchers to compare cosmeceuticals about their properties to combat or reverse cutaneous photoaging changes. In the present experiment, five cosmeceuticals were topically administered to the dorsal skin over 2 weeks in the nonirradiated mice, and skin samples were analyzed for dermal histopathological changes. Histomorphometric procedures were employed to generate quantitative data on skin sections prepared with immunohistochemistry and staining technics, and the data statistically examined. Among the five agents tested, glycolic acid and retinoic acid produced striking changes, while vitamin C, estrogen, and soy product resulted in less remarkable responses. These quantitative data will be useful for further photoaging studies with these cosmeceuticals.

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Section: Discussionsupporting

confidence: 43%

Dermal Histology in Mouse Skin Exposed to Cosmeceuticals

et al. 2017

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“…Soy isoflavone significantly ameliorated skin aging by increasing HA and HAS. These findings indicate the potential of soy isoflavone to prevent skin aging (Bhattacharyya, Higgins, Sebastian, & Thomas, ; Huang et al, ; Miyazaki et al, ).…”

Section: Effect On Water Contentmentioning

confidence: 88%

“…Bhattacharyya TK et al found that the topical use of soy cream on the skin of mice can significantly increase the amount of HA compared with the control group. The phytoestrogen‐rich soybean component can delay skin aging by improving skin moisture content (Bhattacharyya et al, ).…”

Section: Effect On Water Contentmentioning

confidence: 99%

Recent advances in the anti‐aging effects of phytoestrogens on collagen, water content, and oxidative stress

Liu

Yan

et al. 2019

Phytotherapy Research

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Skin undergoes degenerative changes as it ages, which include the loss of elasticity, reductions in the epidermal thickness and collagen content, elastic fiber degeneration, and increased wrinkling and dryness. Skin aging can be significantly delayed by the administration of estrogen. Estrogen deficiency following menopause results in atrophic skin changes and the acceleration of skin aging. Estrogen administration has positive effects on human skin by delaying or preventing skin aging manifestations, but the use of estrogen replacement is a risk factor for breast and uterine cancer. Phytoestrogens are a large family of plant‐derived molecules possessing various degrees of estrogen‐like activity; they exhibit agonist or antagonist estrogenic properties depending on the tissue. These molecules could be ideal candidates to combat skin aging and other detrimental effects of hypoestrogenism. In this paper, we review the effects of phytoestrogens on human skin and the mechanisms by which phytoestrogens can alleviate the changes due to aging.

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“…Morphometry was performed to obtain the following data: (1) epidermal width; (2) total dermal width; (3) ratio of collagen layer to total dermis; (4) ratio of collagen I: collagen III from Herovici polychrome stain preparation (red and blue fibers); (5) count of mast cells; (6) intersection pointcounting to determine fractional area of elastic fibers; 14 and (7) count of PCNA-positive cells to determine epidermal proliferation index. 15,16 Quantitative results are expressed as means¡ standard deviation, and differences between mean scores were analyzed by non-parametric KruskalWallis k-sample test using SPSS16.0 and Excel softwares.…”

Section: Methodsmentioning

confidence: 99%

Cutaneous injury following acute UV-B radiation in a mouse model: a pilot histological study

Bhattacharyya¹,

Bennett²,

Vargas³

et al. 2013

Journal of Histotechnology

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Epidemiological and clinical studies have implicated solar ultraviolet (UV) radiation, especially the UV-B radiation (290-320 nm wavelengths) as the principal agent that elicits sunburn, transient inflammation, melanoma and non-melanoma cancer, and premature skin aging. The common form of skin damage described as 'photoaging' is caused by repeated sun exposures; it can induce epithelial deoxyribonucleic acid (DNA) damage, and alter the structure and function of dermal connective tissue and extracellular matrix. The present study was aimed to elucidate the effects of a single exposure of different doses of UV-B radiation on the dorsal skin in the hairless mouse. The histopathologic sequels of such exposures were analyzed by using common staining methods, immunohistochemistry, and histomorphometry. Single UV-B exposures seem to elicit dose-graded histological changes some of which have been described in experiments with chronic exposure in this species.

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Comparison of Epidermal Morphologic Response to Commercial Antiwrinkle Agents in the Hairless Mouse

Abstract: These baseline data will be useful for future studies on the effect of ultraviolet radiation to cause photoaging and reparative effects of similar agents in this animal. The information contained in the report may provide guidelines to consumers and clinicians.

Cited by 15 publications

References 45 publications

Dermal Histology in Mouse Skin Exposed to Cosmeceuticals

Dermal Histology in Mouse Skin Exposed to Cosmeceuticals

Recent advances in the anti‐aging effects of phytoestrogens on collagen, water content, and oxidative stress

Cutaneous injury following acute UV-B radiation in a mouse model: a pilot histological study

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