Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section

Haynes, Shelley; Allsop, J. R.; Davidson, I.; Dutton, David

doi:10.1016/0959-289x(93)90034-f

Cited by 5 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A wide range of opioid dosages have been used either alone or in combination with bupivacaine via the epidural route. Most studies have given an opioid bolus and assessed the analgesic effect and the duration of action [3,4,7,9,14,[16][17][18][19][20][21][22][23]. From these data we calculated approximately equipotent 24-h dosages for each drug.…”

Section: Discussionmentioning

confidence: 99%

“…The patients often received opioids by more than one route in the perioperative period and observations on side-effects were, in many cases, retrospective [1,[3][4][5][6][7].…”

mentioning

confidence: 99%

“…Previous studies comparing epidural opioids have included patients having a variety of surgical procedures and anaesthetic techniques [1][2][3]. The patients often received opioids by more than one route in the perioperative period and observations on side-effects were, in many cases, retrospective [1,[3][4][5][6][7].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Side‐effects of epidural infusions of opioid bupivacaine mixtures

Gedney

Liu

1998

Anaesthesia

View full text Add to dashboard Cite

SummaryThe incidence of side-effects occurring with epidural diamorphine (0.05 mg.ml ¹1 ), fentanyl (2.0 mg.ml ¹1 ), methadone (0.1 mg.ml ¹1 ), morphine (0.05 mg.ml ¹1 ) and pethidine (1.0 mg.ml ¹1 ) used by infusion in combination with bupivacaine has been compared. One hundred and sixty patients were studied, 32 receiving each opioid. The incidence of nausea and vomiting was significantly greater with morphine than fentanyl (p ¼ 0.0097) and pethidine (p ¼ 0.0021). The incidence of pruritis was significantly greater with morphine and diamorphine than with methadone (p ¼ 0.012) and pethidine (p ¼ 0.027). Morphine was also associated with a significantly greater incidence of urinary retention than pethidine (p ¼ 0.012) and methadone (p ¼ 0.025).

show abstract

Section: Discussionmentioning

confidence: 99%

“…The patients often received opioids by more than one route in the perioperative period and observations on side-effects were, in many cases, retrospective [1,[3][4][5][6][7].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Side‐effects of epidural infusions of opioid bupivacaine mixtures

Gedney

Liu

1998

Anaesthesia

View full text Add to dashboard Cite

show abstract

“…A analgesia pós-operatória após administração da metadona por essa via foi considerada satisfatória após diversos procedimentos cirúrgicos, tais como toracotomia (Parramon et al, 2003), laparotomia (Prieto-Alvarez et al, 1997) e cirurgia corretiva de hérnia de disco lombar (Hernandez-Palazon et al, 1997). A incidência de efeitos adversos após a administração epidural de metadona foi baixa e consistiu em depressão respiratória (PrietoAlvarez et al, 1997;Shir et al, 2001), náuseas e prurido (Haynes et al, 1993), sendo a incidência de alguns desses efeitos mais baixa quando comparada à de outros opióides (morfina e fentanil) pela mesma via (Gedney e Liu, 1998).…”

Section: Nounclassified

Efeitos da metadona ou do neostigmine, associados à lidocaína administrados pela via epidural em cães

Monteiro

Dossi

Antunes

et al. 2008

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

RESUMOSeis cães adultos, de raças e sexos variados, com peso de 13,3±3,4kg (média±DP), foram utilizados no estudo. Os animais foram tranqüilizados com acepromazina (0,1mg/kg, IV) e, após 30 minutos, foram aleatoriamente submetidos à anestesia epidural com um dos seguintes tratamentos: lidocaína 2% 0,25ml/kg (controle); neostigmine 0,01mg/kg+lidocaína (NEO); metadona 0,3mg/kg+lidocaína (MET). Todos os animais foram submetidos aos três tratamentos com intervalo mínimo de uma semana. Foram mensuradas as freqüências cardíaca (FC) e respiratória (FR), a pressão arterial sistólica (PAS), o tempo para a perda do reflexo interdigital, a duração e a altura do bloqueio sensitivo, durante um período de 90 minutos. Não houve diferença significativa entre os tratamentos nos valores de FC, PAS e FR, bem como na duração do bloqueio sensitivo e no tempo para a perda do reflexo interdigital. No grupo MET, houve diminuição de FC dos 30 aos 90 minutos em relação ao valor basal. Bloqueio sensitivo mais cranial também foi observado em MET. A associação de neostigmine ou metadona não prolongou o período hábil de anestesia epidural produzido pela lidocaína em cães. A metadona, mas não o neostigmine, parece estender mais cranialmente o bloqueio epidural pela lidocaína.Palavras-chave: cão, anestesia epidural, metadona, neostigmine, lidocaína ABSTRACT Six mature mongrel dogs of both genders, weighing 13.3±3.4kg (mean±SD) were used in the present research. Thirty minutes after premedication with intravenous acepromazine (0.1mg/kg, IV), dogs were randomly assigned to receive epidural administration of one of following three treatments: 2% lidocaine 0.25ml/kg (control), or neostigmine 0.01mg/kg plus lidocaine (NEO), or methadone 0.3mg/kg plus lidocaine (MET). All dogs received all treatments in a cross-over design with at least one-week interval. Heart rate (HR), respiratory rate (RR),

show abstract

“…The addition of opioids to local anaesthetic drugs is recognized as prolonging their action, resulting in improved analgesia, but with an increased incidence of side‐effects, particularly pruritis and respiratory depression ( 122). It is recognized that epidural opioids in adults can produce significant respiratory depression with associated hypoxaemia ( 123). There is however, contrary evidence in children, including a series of 500 children who received caudal morphine without documented hypoxaemia or respiratory depression ( 124).…”

Section: Postoperative Analgesiamentioning

confidence: 99%