Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery

A Practical Tranexamic Acid Dosing Scheme Based on Population Pharmacokinetics in Children Undergoing Cardiac Surgery

“…even if a unique dose was sometimes administered before skin incision, 7,11,14 dosing schemes were usually based on a loading dose before incision and another dose in the CPB prime volume, in combination with a continuous infusion throughout surgery 7,9,10 or with another bolus at the end of CPB. [6][7][8]15 In addition, a significant variability between practitioners may be observed for each of those doses, as already illustrated with a 10-fold factor in the total dose (i.e., dose ranging from 30-300 mg/kg). 6,8 Some dosing schemes have been inspired from pharmacokinetic data in adults, 16 but the relevance of such an extrapolation may be questioned, because differences in the pharmacokinetics between adults and children undergoing cardiac surgery with CPB have already been reported.…”

Intraoperative Tranexamic Acid Reduces Blood Transfusion in Children Undergoing Craniosynostosis Surgery

“…TXA suppresses fibrinolysis by inhibiting plasminogen and the binding of plasmin to fibrin. 12 TXA has decreased intraoperative blood loss during cardiac surgery [13][14][15][16][17][18] and surgical correction of scoliosis in children.…”

Prevention and Treatment of Thrombosis in Pediatric and Congenital Heart Disease

“…There have been 11 comparative studies of lysine analogs in pediatric patients totaling >1000 patients. 147,[445][446][447][448][449][450][451][452][453][454][455] These are well described in a recent review and meta-analysis, and Table 7 summarizes the results of these studies. 445,456 These studies are of varying quality, and more than half of the patients have come from a single institution, the All-India Institute of Medical Sciences.…”