Comparison of eri and tasar silk fibroin scaffolds for biomedical applications

Abstract

The cultivated silk, mulberry, is being used as biomaterial in different forms. Eri, tasar and muga are some of the known wild silk varieties. The studies on biomedical applications of electrospun mats produced from these wild silks are limited though few studies on eri silk are available. In this work, comparison was made between eri and tasar silk fibroin scaffolds for biomedical application. The scaffolds were produced from eri silk fibroin (ESF) and tasar silk fibroin (TSF) by electrospinning method and they were treated with ethanol to improve dimensional stability. Ethanol treatment increased the crystallinity% of both ESF and TSF scaffolds. The crystallinity percentage of the ESF and TSF scaffolds was found to be 46.7 and 42.8 % respectively. Thermal stability was higher for ESF than that of TSF scaffold. The hemolytic % of ESF and TSF scaffolds was found to be 1.3 and 7.7 % respectively. The platelet adhesion on the surface of ESF scaffold was lower than that found on TSF scaffold. Better fibroblast cell attachment, binding and spreading was found on the ESF scaffold. The cell viability on ESF scaffold was 83.78 % and in TSF was 78.01 % for 48 h. The results showed that ESF electrospun scaffold can be considered as a better biomaterial for biomedical applications compared to that of TSF scaffold.

Sericin–copper-functionalized silk fabrics for enhanced ultraviolet protection and antibacterial properties using response surface methodology

“…Three peaks located at 2 values of 14.36 , 16.99 and 21.12 in both patterns corresponded to the crystalline diffraction of SS-finished silk fibers. 44,45 After in situ synthesis of CuNPs, three further peaks appeared at 2 values of 43.75 , 50.89 and 74.65 , which agreed well with the 111, 200 and 220 diffractions of the facecentered cubic structure of metallic Cu. 26 This confirmed that CuNPs had been successfully loaded onto the SS-finished silk fabrics.…”

In Vitro Assessment of Sericin-Silver Functionalized Silk Fabrics for Enhanced UV Protection and Antibacterial Properties Using Experimental Design

“…Four peaks located at 2θ values of 14.06 • , 17.22 • , 20.75 • , and 28.04 • in both patterns corresponded to the crystalline diffraction of silk fibers [33,34]. After in situ synthesis of AgNPs, three more peaks appeared at 2θ values of 38.41 • , 46.08 • , and 64.45 • , which agreed well with the (111), (200), and (220) diffractions of the face centered cubic (fcc) structure of metallic Ag [35].…”

Deduction of a facile method to construct Antheraea mylitta silk fibroin/gelatin blend films for prospective biomedical applications

“…Similar results have been reported by Andiappan et al showing one weight loss at 100°C and a second at 370°C for tasar silk fibroin scaffolds. 38 Also, for blend films, as observed in Fig. 5, there is a visible shift in the weight loss curve towards lower temperature due to the blending of silk fibroin with gelatin.…”

“…Similar results have been reported by Andiappan et al . showing one weight loss at 100 °C and a second at 370 °C for tasar silk fibroin scaffolds 38 …”