PurposeThe association between the prevalence of patellofemoral arthritis (PFA) and femoral tunnel positioning following isolated medial patellofemoral ligament reconstruction (MPFLr) has not been well described. The aim of this study was to analyse the relationship between femoral tunnel positioning and the prevalence of PFA.MethodsThis was a single‐centre study of patients undergoing an isolated MPFLr between 2006 and 2011 with a minimum of 10 years of follow‐up. Outcomes assessed were the presence of PFA on radiographs, recurrence of instability requiring revision surgery and patient‐reported outcomes, including Kujala, Tegner and IKDC scores. Tunnel positioning was assessed on postoperative radiographs using two radiographic methods: Schöttle's point and the grid method to localise the femoral tunnel. Patients were grouped based on tunnel positioning and compared.ResultsFifty patients were analysed at a mean follow‐up of 12.4 years. Thirty‐three patients (66%) had a femoral tunnel position within 7 mm of Schöttle's point and 39 (78%) within the anatomic quadrant, with the most common location according to the grid method in D4 (28%) and E4 (26%), respectively. Thirty‐seven patients (74%) had a satisfactory (>80 versus <80) Kujala score at long‐term follow‐up. None of the examined tunnel assessment methods demonstrated a significant relationship with Tegner, Kujala or International Knee Documentation Committee scores. Patients with a femoral tunnel position >7 mm outside Schöttle's point or were considered to be in a nonanatomic position were not significantly more likely to result in unsatisfactory Kujala scores at the last follow‐up. Tunnel positioning and the other tested parameters were not found to be significantly associated with the development of PFA.ConclusionNo correlation between femoral tunnel position and risk of PFA or poor outcomes was observed in patients undergoing isolated MPFLr at long‐term follow‐up. The impact of femoral tunnel placement on long‐term outcomes in patients with PFI may be less significant than originally considered.Level of EvidenceLevel IV.