Comparison of Fast Peritoneal Equilibrium Test With the Standard Method: A Pilot Study

Abstract

SUMMARY Standard peritoneal equilibrium test (PET) is an implementation that requires hard work for peritoneal dialysis (PD) staff. We analysed the efficacy of the fast PET and compared its results with standard PET. Forty‐nine patients on PD therapy were included in the study. For standard PET, glucose, urea and creatinine values of dialysate were analysed at zeroth, second and fourth hours, and the patient's serum glucose, urea and creatinine values were analysed at second hour. In the fast PET, urea, glucose and creatinine values in plasma and dialysate were analysed at the fourth hour only. The results of both methods were compared with Pearson correlation and kappa tests. According to the standard PET, low transport in five patients, low‐average transport in 17 patients, high‐average transport in 23 patients and high transport types in four patients were identified. Fast PET results were similar in 46 (94%) patients (r = 0.77, p = 0.0001). Kappa (κw) analysis of results of both PETs was also statistically significant (p = 0.0001). This study showed that the peritoneal transport type may be determined more easily, practically and faster.

Comparison of three PET methods to assess peritoneal membrane transport

“…Baştuğ et al (17) demonstrated, using Pearson's correlation and bias assessment with the Bland-Altman test, that the characterization of transport using PET and mini-PET was similar, as was the categorical classification of high, average, and low transport using D/P creatinine evaluation. Kazancioğlu et al (18) and Cano et al (19) also demonstrated a positive correlation between t-PET and mini-PET, performed by infusing the dialysate for 2 h.…”

“…Performing t-PET is laborious and time-consuming and, therefore, the use of simpler and quicker methods, such as the mini-PET, has been studied, with different results (13 –18). La Milia et al (7) demonstrated equivalence between mini-PET and t-PET in the characterization of small molecule transport.…”

Could mini-PET be used to instead of 4 h original-PET to assess peritoneal permeability in children on peritoneal dialysis?

“…Therefore, several studies have been attempted to validate short and fast PET protocols, with controversial results. [5][6][7][8][9][10][11][12][13] In recent years, a short 2-h version of the original PET has been validated in pediatric clinical practice. 5,12 However, although most centers use this test to prescribe PD therapy, morbidity and mortality secondary to cardiovascular disturbances remains the main complication in PD patients, and the best method to quantify UF capacity of the peritoneum has become a critical question.…”

“…6,7,11 Most of the studies that short and fast PET protocols compared with original PET have been made in adult peritoneal dialysis (PD) patients. [6][7][8][9][10]12,13 The studies on this topic in children are limited number. 5,11,12 Peritoneal permeability has varies in children and adult due to differences in the effective surface area and the maturation of peritoneal membrane.…”

“…Many other tests have been tested the short and fast PET methods. [5][6][7][8][9][10][11][12][13] Recently developed test, mini-PET, is promising tools to assess free water transport (FWT). [6][7][8][9]11 The mini-PET is performed with a 3.86% glucose-based solution, but the dwell time is only 1 h. More recently, D/P creatinine at mini-PET showed a relationship with D/P creatinine at 4 h 3.86% modified PET that was dependent on the actual value.…”