Comparison of fatigue, depression, and anxiety as factors affecting posttreatment health‐related quality of life in lung cancer survivors

Jung, Ju Youn; Lee, Jong Mog; Kim, Moon Soo; Shim, Young Mog; Zo, Jae Ill; Yun, Young Ho

doi:10.1002/pon.4513

Cited by 58 publications

(38 citation statements)

References 33 publications

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“…Besides CIPN, fatigue is also a highly prevalent problem among cancer survivors, with prevalence rates up to 90% . Fatigue is one of the most debilitating symptom among cancer patients and has been related to a worse HRQoL, a higher cancer recurrence, and a poorer survival . CIPN has been related to fatigue in previous research, but the mechanisms underlying this relationship are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Anxiety and depression mediate the association between chemotherapy‐induced peripheral neuropathy and fatigue: Results from the population‐based PROFILES registry

et al. 2019

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Objective Chemotherapy‐induced sensory peripheral neuropathy (CIPN) is common among colorectal cancer (CRC) survivors. The aim of this study was to examine whether CIPN is associated with both psychological distress (ie, anxiety and depression) and fatigue and whether the relationship between CIPN and fatigue can (partly) be explained by psychological distress. Methods All CRC survivors diagnosed between 2000 and 2009 as registered by the population‐based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy‐treated survivors completed questions on CIPN (EORTC QLQ‐CIPN20), psychological distress (HADS), and fatigue (FAS) on average 5.6 years after diagnosis. Simple and multiple mediation analyses were performed to examine anxiety and depression as possible mediators in the association between CIPN and fatigue. Results Survivors with high (ie, upper 30% of scores) CIPN (n = 172) reported more anxiety and depressive symptoms and more fatigue compared with those with low CIPN (n = 299). Furthermore, among survivors with high CIPN, those who were anxious, depressed, or both reported more fatigue compared with those without psychological distress. These differences were clinically relevant. Finally, mediation analyses showed that while CIPN was directly associated with fatigue, the relationship between CIPN and fatigue was also significantly mediated by both anxiety and depression. Conclusions CRC survivors with high CIPN report more fatigue, especially those who are also anxious and/or depressed. More research is needed on the direction of the relationship between CIPN, psychological distress, and fatigue. For now, the treatment of fatigue should also focus on addressing psychological distress, as treating fatigue alone might not be sufficient.

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Section: Introductionmentioning

confidence: 99%

Anxiety and depression mediate the association between chemotherapy‐induced peripheral neuropathy and fatigue: Results from the population‐based PROFILES registry

et al. 2019

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“…Fatigue is described as being subjective, multidimensional and variable in severity with physical, emotional, mental, functional and spiritual components (Pearson, Morris, Stefano, & McKinstry, ; Wu & Davis, ). Studies exploring patients' symptom experiences have shown that patients consistently rate fatigue as the most severe symptom, compromising the individual's physical functioning as well as their quality of life (Jung et al, ; Wang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Cancer‐related fatigue and self‐care agency: A multicentre survey of patients receiving chemotherapy

O'Regan

McCarthy

O’Reilly

et al. 2019

Journal of Clinical Nursing

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Aims and objectives To measure cancer‐related fatigue (CRF), self‐care agency (SCA) and fatigue self‐care strategies, and to explore the relationship between CRF and SCA. Background Cancer‐related fatigue has been consistently rated as the most elusive, common and severe of symptoms that patients with cancer undergoing chemotherapy experience. Despite its frequency and severity, CRF is poorly managed. A renewed focus on supporting self‐care among patients with cancer has been found to reduce symptom burden, empower patients and improve patient satisfaction. Understanding the link between self‐care agency (i.e. capability and willingness to self‐care) and CRF levels will help practitioners to better support individuals on the cancer journey. Design A descriptive, correlational survey design was employed. Methods Patients (n = 362) undergoing chemotherapy with a primary diagnosis of breast, colorectal, Hodgkin's and non‐Hodgkin's lymphoma cancers were recruited from four oncology centres in one city in the South of Ireland. Participants completed the Piper Fatigue Scale‐Revised, Appraisal of Self‐care Agency Scale and a researcher‐developed Fatigue Self‐Care Survey. Multivariate logistic regression was used to examine the relationship between CRF and self‐care agency using a dichotomous dependent variable score of four as the cut‐off between those deemed to be fatigued (≥4) and those not fatigued (<4). As recommended by the EQUATOR Network, the STROBE checklist of items for cross‐sectional studies is used to report the study. Results The incidence of CRF was high with 75% of participants scoring clinically relevant CRF. Higher SCA (OR = 0.96, 95% CI = 0.93–0.99, p = .011) was associated with decreased odds of developing CRF. Having non‐Hodgkin's lymphoma (OR = 3.02, 95% CI = 1.29–7.07, p = .011) was associated with increased odds of developing CRF. Conclusions Patient's undergoing chemotherapy experience significant fatigue. Higher capability for self‐care is associated with lower fatigue. The promotion of SCA and self‐care strategies can impact on CRF. Relevance to clinical practice Understanding the link between self‐care abilities and fatigue can lead to more individualised and tailored approaches to CRF.

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“…Ha and colleagues report borderline anxiety and depression scores (> seven on the HADS subscales) in 19% and 31% of participants respectively. Recent work in a sample of 830 lung cancer survivors reports similar rates of borderline anxiety (21%) and higher rates of borderline depression (39%) (24). Abnormal levels of fatigue (scores >40) were also reported in 42% of participants in the study by Jung and colleagues (24), compared to only 24% reported by Ha and colleagues.…”

mentioning

confidence: 86%

“…Recent work in a sample of 830 lung cancer survivors reports similar rates of borderline anxiety (21%) and higher rates of borderline depression (39%) (24). Abnormal levels of fatigue (scores >40) were also reported in 42% of participants in the study by Jung and colleagues (24), compared to only 24% reported by Ha and colleagues. Hospitalised patients prior to commencing treatment report high levels of anxiety and depression (65% for both anxiety and depression) (25).…”

mentioning

confidence: 86%

The nexus of functional exercise capacity with health-related quality of life in lung cancer: how closely are they related?

2018

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Comparison of fatigue, depression, and anxiety as factors affecting posttreatment health‐related quality of life in lung cancer survivors

Abstract: Relative to depression and anxiety, fatigue exerted a stronger effect on lung cancer survivors' HRQoL. Health professionals should consider the reduction of fatigue a priority in improving cancer patients' HRQoL following the completion of cancer treatment.

Cited by 58 publications

References 33 publications

Anxiety and depression mediate the association between chemotherapy‐induced peripheral neuropathy and fatigue: Results from the population‐based PROFILES registry

Anxiety and depression mediate the association between chemotherapy‐induced peripheral neuropathy and fatigue: Results from the population‐based PROFILES registry

Cancer‐related fatigue and self‐care agency: A multicentre survey of patients receiving chemotherapy

The nexus of functional exercise capacity with health-related quality of life in lung cancer: how closely are they related?

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