Comparison of FDG-PET and dynamic contrast-enhanced MRI in the evaluation of suggestive breast lesions

Heinisch, Martin; Gallowitsch, H. J.; Mikosch, Peter; Kresnik, E.; Kumnig, G.; Gomez, Iris; Lind, Peter; Umschaden, Heinz Werner; Gasser, Johann; Forsthuber, Ernst-Pius

doi:10.1016/s0960-9776(02)00262-x

Cited by 44 publications

(22 citation statements)

References 23 publications

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“…Seven of the 117 tumors were smaller than 10 mm, a threshold beyond which FDG PET demonstrates a known decreased sensitivity because of its limited spatial resolution (20). The correction for partial volume error on PET/CT in this study diminished the relationship between tumor size and SUV max ; this effect is illustrated in the scatter plot in Figure 2.…”

Section: Discussionmentioning

confidence: 68%

Triple-Negative and Non–Triple-Negative Invasive Breast Cancer: Association between MR and Fluorine 18 Fluorodeoxyglucose PET Imaging

Bolouri

Elias²,

Wisner³

et al. 2013

Radiology

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Purpose:To assess the relationship between parameters measured on dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging and fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in primary invasive breast cancer. Materials and Methods:This HIPAA-compliant study was a retrospective review of medical records and therefore approved by the institutional review board without the requirement for informed consent. Patients with a diagnosis of invasive breast cancer from January 2005 through December 2009 who underwent both DCE MR imaging and FDG PET/CT before treatment initiation were retrospectively identified. Fractional volumes were measured for ranges of signal enhancement ratio (SER) values from DCE MR imaging data and compared with maximum standardized uptake values (SUV max ) from FDG PET/CT data. Linear regression analysis was performed to clarify the relationship between SER and SUV max , adjusting for tumor size, pathologic grade, and receptor status. Results:Analyzed were 117 invasive breast cancers in 117 patients. Overall, a higher percentage of high washout kinetics was positively associated with SUV max (1.57% increase in SUV max per 1% increase in high washout; P = .020), and a higher percentage of low plateau kinetics was negatively associated with SUV max (1.19% decrease in SUV max per 1% increase in low plateau; P = .003). These relationships were strongest among triple-negative (TN) tumors (4.34% increase in SUV max per 1% increase in high washout and 2.65% decrease in SUV max per 1% increase in low plateau; P = .018 and .004, respectively). Conclusion:In invasive breast carcinoma, there is a positive relationship between the percentage of high washout and SUV max and a negative relationship between the percentage of low plateau and SUV max . These results are stronger in TN tumors.q RSNA, 2013 Supplemental material: http://radiology.rsna.org/lookup /suppl

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Section: Discussionmentioning

confidence: 68%

Triple-Negative and Non–Triple-Negative Invasive Breast Cancer: Association between MR and Fluorine 18 Fluorodeoxyglucose PET Imaging

Bolouri

Elias²,

Wisner³

et al. 2013

Radiology

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“…2 Benign breast lesions and tumors have also been reported to show up as false-positive cases on FDG-PET. 1,[3][4][5][6] Ductal adenoma of the breast is a benign lesion that can mimic carcinoma, as reported by Azzopardi and Salm. 7 Ductal adenoma clinically, radiologically, and macroscopically can simulate malignancy because of the fi rmness and irregularity of many lesions.…”

Section: Introductionmentioning

confidence: 80%

Mastopathic-type fibroadenoma and ductal adenoma of the breast with false-positive fluorodeoxyglucose positron emission tomography

et al. 2009

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Positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) has been shown to be an effective and accurate diagnostic technique for breast cancer. However, benign breast lesions have also been reported to show a false-positive FDG uptake on PET. We present two cases of benign tumors that revealed FDG uptake on PET and were difficult to distinguish from breast cancer. A 46-year-old premenopausal woman noticed a mass in her right breast. Ultrasonography showed a hypoechoic mass with the size of 7.7 x 3.9 mm and an irregular shape in the right breast. PET demonstrated a focal accumulation of FDG with a maximum standardized uptake value (SUVmax) of 2.1. Excisional biopsy was performed, and ductal adenoma was diagnosed. In the second case, a 36-year-old premenopausal woman was pointed out as showing an abnormality in the left breast on screening mammography. Ultrasonography showed a hypoechoic mass of 1.5 x 1.2 cm in size in the left breast. The lesion was depicted as a mass with prominent enhancement on dynamic CT and a focal accumulation of FDG with SUV max of 3.5 on PET. It was diagnosed as fibroadenoma of mastopathic type histopathologically by excisional biopsy. The readers should be aware that these benign tumors may cause false-positive results on PET.

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“…As a result, sensitivity, specifi city, and accuracy could not be calculated with respect to mammography and US separately. It has been reported that non-invasive ductal carcinoma and small breast cancers less than 1 cm in diameter are not detectable by FDG-PET [27]. On cancer screening, Ide et al [13] have reported that 9 of 44 cases of breast cancer could not be detected by FDG-PET alone.…”

Section: Discussionmentioning

confidence: 99%

Improved detection of breast cancer on FDG-PET cancer screening using breast positioning device

et al. 2008

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In cancer screening, prone breast imaging using a positioning device may help to improve the detection rate of breast cancer. However, overall cancer including mammography and ultrasonography screening should be performed to investigate the false-negative cases and reduce false-positive cases. The effectiveness of prone breast PET imaging in cancer screening should be investigated using a much larger number of cases in the near future.

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Comparison of FDG-PET and dynamic contrast-enhanced MRI in the evaluation of suggestive breast lesions

Cited by 44 publications

References 23 publications

Triple-Negative and Non–Triple-Negative Invasive Breast Cancer: Association between MR and Fluorine 18 Fluorodeoxyglucose PET Imaging

Triple-Negative and Non–Triple-Negative Invasive Breast Cancer: Association between MR and Fluorine 18 Fluorodeoxyglucose PET Imaging

Mastopathic-type fibroadenoma and ductal adenoma of the breast with false-positive fluorodeoxyglucose positron emission tomography

Improved detection of breast cancer on FDG-PET cancer screening using breast positioning device

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