Comparison of features of active infective endocarditis involving native cardiac valves in nonintravenous drug users with and without predisposing cardiac disease

Castillo, Juan Carlos; Anguita, Manuel; Torres, Francisco; Mesa, Dolores; Franco, Manuel; González, Emilio; Ojeda, Soledad; Delgado, Mónica; Vallés, F

doi:10.1016/s0002-9149(02)02851-5

Cited by 15 publications

(10 citation statements)

References 13 publications

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“…It should be noted that more than 17% of all cases developed infective endocarditis without any predisposing cardiac disorders, but it is not certain whether those patients had undiagnosed disorders or were truly without any underlying disorders. It seems that the incidence of infective endocarditis in patients without predisposing cardiac disorders has been increasing, 1,14,15 and this fact should alert us to the possibility of infective endocarditis in a patient who comes in with fever of unknown origin even if there is not a baseline cardiac disease.…”

Section: Underlying Diseasementioning

confidence: 99%

Current Characteristics of Infective Endocarditis in Japan

Nakatani

Mitsutake²,

Hozumi

et al. 2003

Circ J

105

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Section: Underlying Diseasementioning

confidence: 99%

Current Characteristics of Infective Endocarditis in Japan

Nakatani

Mitsutake²,

Hozumi

et al. 2003

Circ J

105

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“…However, even in 20-year-old studies from The Netherlands and France that used the old von Reyn diagnostic criteria [ 8 9 ], ≥ 40% of patients diagnosed with IE had no previous history of predisposing heart disease of any type; IE was the first clinical presentation in these patients ( Table 1 ). Similarly, a study from Spain confirmed this finding, with 40% of patients having no history of heart disease [ 10 ]. Groups of patients without previous underlying heart disease have been found to differ in clinical characteristics, including vegetation site, major infecting microorganism, and mortality rate.…”

Section: Ie In Patients Without Previously Recognized Predisposing Hementioning

confidence: 60%

“…After excluding intravenous drug abusers and patients with pacemakers, Selton-Suty et al [ 9 ] found that IE affected the aortic valve more frequently, with a higher prevalence of group D Streptococci (bovis) and no difference in mortality. By contrast, Castillo et al [ 10 ] found that in patients with pacemakers, vegetation was more frequent in the right cardiac chamber and the mitral valve than in the aortic valve, and that the prevalence of Staphylococcus aureus was higher and mortality rates were significantly lower.…”

Section: Ie In Patients Without Previously Recognized Predisposing Hementioning

confidence: 96%

“…These discrepancies may have been due to differences in inclusion criteria and study settings (a national survey versus an observational study in a single-center). It is interesting that another single-center study by Castillo et al [ 10 ] also showed an increasing tendency during the study period [ 10 ].…”

Section: Ie In Patients Without Previously Recognized Predisposing Hementioning

confidence: 99%

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Infective endocarditis involving an apparently structurally normal valve: new epidemiological trend?

Song

2015

Korean J Intern Med

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Infective endocarditis (IE) has been increasingly diagnosed in patients without previously detected predisposing heart disease, but its clinical features have yet to be fully determined. A recent single-center study including echocardiographic images and surgical findings investigated the incidence of undiagnosed, clinically silent valvular or congenital heart diseases and healthcare-associated infective endocarditis (HAIE). The study confirmed that a large proportion of patients with IE have no previous history of heart disease. Analysis of underlying disease in these patients showed that undetected mitral valve prolapse was the most common disease, followed by an apparently structurally normal valve. The patients who developed IE of apparently structurally normal valves had different clinical characteristics and worse outcomes. IE involving a structurally normal valve was associated with both nosocomial and non-nosocomial HAIE, whereas community-acquired IE was more frequent than HAIE. The pathophysiologic mechanism involving the development of non-HAIE or community-acquired IE due to predominantly staphylococcal infection in an apparently structurally normal valve is not yet clearly understood. Structurally normal valves are not necessarily free of regurgitation or abnormal turbulence and, given the dynamic nature and fluctuating hemodynamic effects of conditions such as poorly controlled hypertension, end-stage renal disease, and sleep apnea, further investigation is necessary to evaluate the potential role of these diseases in the development of IE. An apparently normal-looking valve is associated with IE development in patients without previously recognized predisposing heart disease, warranting repartition of at-risk groups to achieve better clinical outcomes.

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“…We must be aware that the prevalence of tricuspid valve endocarditis (TVE) in non-intravenous drug users (non-IVDUs) is rising,1 therefore a high index of suspicion and low threshold for investigation to exclude infective endocarditis should not just be applicable to high-risk groups (for example, intravenous drug users) but anyone who presents with a pyrexia of unknown origin.…”

Section: Introductionmentioning

confidence: 99%

Lost without Occam's razor: Escherichia coli tricuspid valve endocarditis in a non-intravenous drug user

Foley

Augustine²,

Bond³

et al. 2010

Case Reports

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SummaryThe unusual case of a 31-year-old woman who developed tricuspid valve endocarditis with positive blood cultures for Escherichia coli is presented. The patient had no underlying cardiac disease or predisposing conditions that could have made her susceptible to the native valve infection. Despite a lengthy course of intravenous antibiotics only a partial response was achieved. The patient underwent cardiac surgery and had a good postoperative recovery. BACKGROUND

show abstract

Comparison of features of active infective endocarditis involving native cardiac valves in nonintravenous drug users with and without predisposing cardiac disease

Cited by 15 publications

References 13 publications

Current Characteristics of Infective Endocarditis in Japan

Current Characteristics of Infective Endocarditis in Japan

Infective endocarditis involving an apparently structurally normal valve: new epidemiological trend?

Lost without Occam's razor: Escherichia coli tricuspid valve endocarditis in a non-intravenous drug user

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