Comparison of Fentanyl, Sufentanil, and Alfentanil Anesthesia in Patients Undergoing Valvular Heart Surgery

Fentanyl or Sufentanil Continuous Infusion During Isoflurane Anaesthesia in Dogs: Clinical Experiences

“…Sufentanil, another m-opioid receptor agonist, is the thienyl analogue of 4-nilinopiperidine (Mendes and Selmi, 2003;Bufalari et al, 2004). Both agents have been used for the induction and maintenance of analgesia, especially in humans (Bovill et al, 1984;Ahonen et al, 2000). To our knowledge, there are no clinical comparative reports of the infusion of fentanyl or sufentanil during isoflurane anaesthesia in dogs.…”

Reversible Diastolic Dysfunction After Successful Coronary Artery Bypass Surgery

“…Two patients received dopamine at 5 p.g/ kg/ min at 4 h after CPB, and this dose was continued in one patient at 20 h after CPB. 23 Several studies have demonstrated diminished LV systolic function to occur immediately after CPB.l-6 This depression of LV function also has been observed to resolve within 24 h when patients were serially studied by radionuclide ejection fraction techniques. Hemodynamic and echocardiographic data appear in Table l.…”

Alfentanil in Anesthesia and Analgesia

“…[16][17][18][19][20] Maintenance of anesthesia requires frequent administration of alfentanil because of the short duration of alfentanil action. 16 -2o For this reason, alfentanil should be administered as a variable rate continuous intravenous infusion.…”

“…20 In the only randomized comparison of fentanyl, sufentanil, and alfentanil, all three drugs produced satisfactory anesthesia and hemodynamic stability for cardiac valve replacement surgery, but hemodynamics were more stable in the patients who received alfentanil. 20 With any of these three drugs it is sometimes difficult to prevent increases in arterial pressure during sternotomy and sternal spread. Chronic preoperative beta-blocker therapy can reduce the frequency of hypertensive episodes during surgery and reduce the dose of opioid required to maintain satisfactory anesthesia.v" Recovery from anesthesia is more rapid following alfentanil-oxygen anesthesia than after fentanyl-oxygen anesthesia."…”

“…Awareness and recall of operations has not been a problem to date with alfentanil-oxygen anesthesia. [16][17][18][19][20] Alfentanil has been used effectively for postoperative analgesia in ventilated and spontaneously breathing patients. [1][2][3][4] Because it produces analgesia for only about 10 minutes following a single intravenous bolus dose, alfentanil has been administered as a variable rate continuous infusion for up to 130 hours postopera- tively.v" Alfentanil has also been administered via devices for patient-controlled analgesia.…”