2020
DOI: 10.5946/ce.2020.022
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Comparison of Fentanyl versus Meperidine in Combination with Midazolam for Sedative Colonoscopy in Korea

Abstract: Background/Aims: Combination of midazolam and opioids is used widely for endoscopic sedation. Compared with meperidine, fentanyl is reportedly associated with rapid recovery, turnover rate of endoscopy room, and quality of endoscopy. We compared fentanyl with meperidine when combined with midazolam for sedative colonoscopy. Methods: A retrospective, cross-sectional, 1:2 matching study was conducted. Induction and recovery time were compared as the primary outcomes. Moreover, cecal intubation time, withdrawal t… Show more

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Cited by 6 publications
(9 citation statements)
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“…The good safety profile of meperidine compared with fentanyl is also well-documented in other studies on gastrointestinal endoscopy comparing these two agents. 25,30 The planned sample scheme was completed in 90.7% of procedures; nevertheless, in 97% of the total procedures at least a sample was obtained, whereas in 85% cases samples were adequate. This result is more significant than other reports in different studies, 31 supporting the efficacy of conscious sedation in terms of accomplishment of the scheduled procedure and diagnostic yield.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The good safety profile of meperidine compared with fentanyl is also well-documented in other studies on gastrointestinal endoscopy comparing these two agents. 25,30 The planned sample scheme was completed in 90.7% of procedures; nevertheless, in 97% of the total procedures at least a sample was obtained, whereas in 85% cases samples were adequate. This result is more significant than other reports in different studies, 31 supporting the efficacy of conscious sedation in terms of accomplishment of the scheduled procedure and diagnostic yield.…”
Section: Discussionmentioning
confidence: 99%
“…17,19 The aim of this study was to assess efficacy and safety of EBUS-TBNA under conscious sedation with meperidine and midazolam performed by pulmonologists, in terms of complete sampling of lymph nodes after consulting radiological imaging, diagnostic yield, and patient's satisfaction. The choice of these drugs is related with the current evidences: midazolam is the most used and recommended drug for conscious sedation during flexible bronchoscopy, 20,21 whereas meperidine, although discussed, 22 has been widely investigated and used both in bronchoscopic procedures 23 and in digestive endoscopic procedures 24,25 with good results.…”
Section: Introductionmentioning
confidence: 99%
“…However, propofol manufacturers in Japan and several other countries restrict its use to personnel trained in general anesthesia [ 9 ]. Therefore, many facilities use benzodiazepines and/or opiates for endoscopic sedation [ 10 - 12 ]. Our endoscopy-specialized clinic also uses midazolam and/or pethidine [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…9 Therefore, many facilities use benzodiazepines and/or opiates for endoscopic sedation. [10][11][12] Our endoscopy-specialized clinic also uses midazolam and/ or pethidine. 13 Even when antagonists such as flumazenil and naloxone are used, recovery from sedation takes time.…”
mentioning
confidence: 99%
“…2,3 Accordingly, a dose reduction in midazolam with opioid analgesics has been positively considered for paradoxical reactions. 4,5 Additionally, the administration of flumazenil, an antidote for midazolam, can completely and effectively reverse midazolam-induced paradoxical reactions. 6,7 However, flumazenil may induce withdrawal symptoms, such as confusion and agitation, in patients with benzodiazepine dependence.…”
mentioning
confidence: 99%