Comparison of fentanyl with dexmedetomidine for smooth extubation: A clinical study

Abstract

Introduction: In general anaesthesia, commonly due to sympathetic responses patients develop tachycardia and increased secretion and bronchospasm while extubation. Fentanyl and dexmedetomidine are well known to suppress airway reflexes during airway procedures. Aim: This study is design to compare the effects of fentanyl 1 µg/kg and dexmedetomidine 0.75 µg/kg in attenuating airway and circulatory reflexes during emergence and extubation of the endotracheal tube. Materials and Methods: This double-blind, randomized, controlled study was done in fifty patients undergoing surgery under general anaesthesia belonging to (ASA) physical status 1 or 2. Study drugs dexmedetomidine (Group D) & Fentanyl (Group F) was given 15 min before the end of surgery as an infusion and over 15 min post extubation. Hemodynamic parameters and patient response for laryngoscopy like respiratory pattern, airway status and oral suctioning and during extubation were graded. Discussion: Aside from measurably huge drop in BP at 5 min of medication organization which reacted to liquid bolus in the dexmedetomidine assemble there were no unfriendly symptoms amid the examination time frame. Both groups had a similar duration of recovery from anesthesia. Dexmedetomidine before 15 minutes of extubation obtain better results. Dexmedetomidine was found to produce hypotension at 5 min of drug infusion and improved with fluid bolus; HR was stable throughout the study period. Conclusion: Extubation quality was found to be superior in dexmedetomidine group with patients arousable and tolerating suctioning and extubation. Whereas in fentanyl group, patients were awake during extubation and had tachycardia after extubation.