Comparison of Fetomaternal Complications in Women of High Parity with Women of Low Parity among Saudi Women

Khan, Farida Habib; Alkwai, Hend M.; Alshammari, Reem Falah; Alenazi, Fahaad; Alshammari, Khalid Farhan; Sogeir, Ehab Kamal Ahmed; Batool, Asma; Khalid, Ayesha Akbar

doi:10.3390/healthcare10112198

Cited by 5 publications

(2 citation statements)

References 31 publications

(83 reference statements)

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“…Additionally, it has also a strong impact on decreased fertility and increased infertility during a woman's life [70], such as a decline in ovarian reserve, a long time to conceive, a low rate of ovarian stimulation, unhealthy menstruation, increased risk of miscarriage, hormonal changes, high risk of multiple gestations/pregnancy complications, low pregnancy rate and high chances of having birth defects. In Saudi Arabia, there are many studies that support the above complications in FI women [71][72][73]. In this study, we did not record the complications present in FI women, which can be considered another limitation of this study.…”

Section: Discussionmentioning

confidence: 85%

Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women

Alageel,

Alhaizan,

Neyazi

et al. 2023

Applied Sciences

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Infertility is a major issue at present and is a common disease that exists in both male and female reproductive systems, described as failure to attain pregnancy. The most important physiological phenomenon for establishing clinical pharmacy is defined as female infertility (FI). Obesity enhances the risks for many chronic disorders, especially causing a high risk for women’s reproductive health. The relationship between infertile women and thrombophilia is characterized by abnormal blood coagulation. Among the thrombophilic variants, Factor V Leiden (FVL), prothrombin (PT) and methyl tetrahydrofolate reductase (MTHFR) in genes such as G1691A (rs6020), G20210A (rs1799963) and C677T (rs1801133) are commonly studied in the majority of human diseases. In this case–control study, we investigated the role of thrombophilic variants such as G1691A, G20210A and C677T in the FVL, PII and MTHFR genes in Saudi infertile women. Based on sample size calculation, 100 female infertile and 100 control (fertile) women were selected based on inclusion and exclusion criteria. Genotyping was performed with polymerase chain reaction and followed with precise restriction enzymes, which can accurately detect the nucleotide amendment variants in G1691A, G20210A and C677T. The required statistics were applied between the case (infertile) and control (fertile) women to document the role of the G1691A, G20210A and C677T variants in Saudi infertile women. In this study, age, weight and BMI were found to be high in the control women in comparison to the infertile women. None of the genotypes, genetic models or allele frequencies were associated with G1691A, G20210A or C677T SNPs (p > 0.05). Furthermore, the regression model and ANOVA analysis also showed negative statistical associations. The combination of genotypes and allele frequencies among G1691A, G20210A and C677T SNPs showed positive associations in the recessive model (p = 0.0006). Finally, the GMDR model showed moderate associations with the gene–gene interaction, dendrogram and depletion models. Finally, this study confirmed that thrombophilic SNPs have no role and may not be involved in Saudi infertile women.

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Section: Discussionmentioning

confidence: 85%

Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women

Alageel,

Alhaizan,

Neyazi

et al. 2023

Applied Sciences

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“…In addition, evidence suggests that women with high parity, defined as having 5 or more births, are more likely to limit future fertility through the use of contraception (Amin, Mariam, and Faruqee 1987; Khan et al. 2022). We anticipate that interventions to help women increase their access to and use of contraception will be strongly influenced by these underlying patterns.…”

Section: Introductionmentioning

confidence: 99%

Rural Residence, Motorcycle Access, and Contraception Use in South and Southeast Asia^☆

Muir,

Sanders,

Hendricks

et al. 2024

Rural Sociology

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Access to contraception is critical for limiting fertility. Yet, in South and Southeast Asia, access to these resources is often limited by spatial inequalities between rural and urban areas. Access to a motorcycle may empower women living in rural areas to attenuate these spatial inequalities, increase their educational attainment and participation in labor markets, and thereby facilitate a shift in fertility preferences. Concomitantly, motorcycle access may increase access to contraception for geographically isolated women who desire to limit fertility. We employ logistic regression models to examine associations with contraception use and unmet need for contraception for women living in rural versus urban areas and for women with versus without access to a motorcycle. Roughly 40 percent of women reported current use of contraception while another 21 percent indicated an unmet need for contraception. After adjusting for other variables, women with a motorcycle were more likely to report current contraception use (AOR = 1.55, 95% CI [1.50, 1.61]), modern contraception use (AOR = 1.60, 95% CI [1.54, 1.66]), and traditional contraception use (AOR = 1.49, 95% CI [1.41, 1.58]) compared with women who did not own a motorcycle. Women with a motorcycle were less likely to report an unmet need for contraception (AOR = 0.65, 95% CI [0.62, 0.68]) after adjusting for other variables. Our results are consistent with the premise that motorcycles facilitate contraception use among women living in resource‐limited countries in South and Southeast Asia and thereby contribute to decreases in fertility. These relationships are contextualized by whether a woman lives in an urban or rural setting, and the number of children already present in their household; they are robust to controlling for household‐level wealth and other factors that may mediate associations with contraception use.

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Multi-organ transcriptomic atlas reveals hallmarks of labor

Ni,

Nanan

2024

Preprint

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Pregnancy and labor are dynamic processes involving various rapid biological changes. Previous studies found that during pregnancy there are gradual alterations in immune and metabolic pathways. In contrast, changes linked to labor are less well-known, generally limited to reports on specific differentially expressed genes, lacking a more comprehensive overview of changes of the overall signalling landscapes. Moreover, most previous works were standalone, based on individual organs. Here, we aimed to present a more systematic and holistic overview of the impacts of labor on both the maternal and fetal aspects. For this purpose, we collated a multi-organ transcriptomic atlas to decipher the influences of labor on multiple maternal and fetal compartments, covering the maternal adipose tissues (subcutaneous and visceral fat), peripheral blood, myometrium and placenta and fetal cord blood mononuclear cells (CBMCs), and spanning both physiological and pathological conditions. During labor, activation of pro-inflammatory TNF signaling was found in all maternal compartments except adipose tissues, which, along with myometrium, showed upregulation in glycolysis. Myc signaling, as a critical nexus within the intracellular signaling network, was generally enhanced in labor. Contrarily, fetal CBMCs in labor upregulated the anti-inflammatory TGFβ pathway. Importantly, changes in the maternal TNF signaling were conserved across the spectrum of healthy pregnancy of different parities, and pathological conditions like preterm pregnancy and smoking-affected pregnancy. Mechanistically, it might be explained by the reduction in progestin hormonal signals during labor but not by the mechanical stress. Collectively, we present a comprehensive multi-organ transcriptomic atlas elucidating the maternal and fetal immune and metabolic landscapes associated with labor, shedding light on the complex physiology.

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Comparison of Fetomaternal Complications in Women of High Parity with Women of Low Parity among Saudi Women

Cited by 5 publications

References 31 publications

Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women

Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women

Rural Residence, Motorcycle Access, and Contraception Use in South and Southeast Asia^☆

Multi-organ transcriptomic atlas reveals hallmarks of labor

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Comparison of Fetomaternal Complications in Women of High Parity with Women of Low Parity among Saudi Women

Cited by 5 publications

References 31 publications

Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women

Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women

Rural Residence, Motorcycle Access, and Contraception Use in South and Southeast Asia☆

Multi-organ transcriptomic atlas reveals hallmarks of labor

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Product

Resources

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Rural Residence, Motorcycle Access, and Contraception Use in South and Southeast Asia^☆